Modulation of the Gut Microbiota by Fufang-Zhenzhu-Tiaozhi Capsule Attenuates Hypertension Induced by a High-Fructose and High-Salt Diet
Hypertension is frequently comorbid with the disorders of glucose and lipid metabolism. The increased intakes of fructose and salt contribute to the development of hypertension and related metabolic disorders, which are closely associated with gut dysbiosis. Fufang-Zhenzhu-Tiaozhi capsule (FTZ), a t...
| Main Authors: | , , , , , |
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| Format: | Article |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2022.854849/full |
| _version_ | 1811332805887524864 |
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| author | Zhe Chen Zhe Chen Zhe Chen Zhe Chen Zhe Chen Bin Yang Bin Yang Bin Yang Bin Yang Zhen Wang Zhen Wang Zhen Wang Zhen Wang Xianglu Rong Xianglu Rong Xianglu Rong Xianglu Rong Qing Zhu Qing Zhu Qing Zhu Qing Zhu Jiao Guo Jiao Guo Jiao Guo Jiao Guo |
| author_facet | Zhe Chen Zhe Chen Zhe Chen Zhe Chen Zhe Chen Bin Yang Bin Yang Bin Yang Bin Yang Zhen Wang Zhen Wang Zhen Wang Zhen Wang Xianglu Rong Xianglu Rong Xianglu Rong Xianglu Rong Qing Zhu Qing Zhu Qing Zhu Qing Zhu Jiao Guo Jiao Guo Jiao Guo Jiao Guo |
| author_sort | Zhe Chen |
| collection | DOAJ |
| description | Hypertension is frequently comorbid with the disorders of glucose and lipid metabolism. The increased intakes of fructose and salt contribute to the development of hypertension and related metabolic disorders, which are closely associated with gut dysbiosis. Fufang-Zhenzhu-Tiaozhi capsule (FTZ), a traditional Chinese patent medicine commonly used in clinical practice, has recently emerged as a promising drug candidate for metabolic diseases. In this study, FTZ treatment is identified as attenuating blood pressure increase and improving the metabolism of lipid and uric acid in high-fructose and high-salt (HFS) diet-fed rats. FTZ also substantially alleviated renal fibrosis and the mRNA expression of inflammation cytokines, NADPH oxidases, and the renin–angiotensin system in the renal cortex. 16S rRNA sequencing of fecal samples revealed that FTZ restored HFS-induced gut dysbiosis, seen as increased intestinal microbial richness and diversity. Furthermore, fecal microbiota transplantation also achieved similar therapeutic effects and alterations in gut microbiota profile induced by FTZ. Taken together, this study highlights the efficacy of FTZ in attenuating HFS-induced hypertension and related metabolic disorders and renal injury. The antihypertensive effect is associated with the modulation of gut microbiota. |
| first_indexed | 2024-04-13T16:42:28Z |
| format | Article |
| id | doaj.art-19833c802840469193d4efe3b71084a6 |
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| language | English |
| last_indexed | 2024-04-13T16:42:28Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-19833c802840469193d4efe3b71084a62022-12-22T02:39:10ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882022-06-011210.3389/fcimb.2022.854849854849Modulation of the Gut Microbiota by Fufang-Zhenzhu-Tiaozhi Capsule Attenuates Hypertension Induced by a High-Fructose and High-Salt DietZhe Chen0Zhe Chen1Zhe Chen2Zhe Chen3Zhe Chen4Bin Yang5Bin Yang6Bin Yang7Bin Yang8Zhen Wang9Zhen Wang10Zhen Wang11Zhen Wang12Xianglu Rong13Xianglu Rong14Xianglu Rong15Xianglu Rong16Qing Zhu17Qing Zhu18Qing Zhu19Qing Zhu20Jiao Guo21Jiao Guo22Jiao Guo23Jiao Guo24Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, ChinaGuangdong Metabolic Disease Research Center of Integrated Chinese and Western Medicine, Guangdong Pharmaceutical University, Guangzhou, ChinaKey Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China, Guangzhou, ChinaGuangdong TCM Key Laboratory for Metabolic Diseases, Guangdong Pharmaceutical University, Guangzhou, ChinaInstitute of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, ChinaGuangdong Metabolic Disease Research Center of Integrated Chinese and Western Medicine, Guangdong Pharmaceutical University, Guangzhou, ChinaKey Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China, Guangzhou, ChinaGuangdong TCM Key Laboratory for Metabolic Diseases, Guangdong Pharmaceutical University, Guangzhou, ChinaInstitute of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, ChinaGuangdong Metabolic Disease Research Center of Integrated Chinese and Western Medicine, Guangdong Pharmaceutical University, Guangzhou, ChinaKey Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China, Guangzhou, ChinaGuangdong TCM Key Laboratory for Metabolic Diseases, Guangdong Pharmaceutical University, Guangzhou, ChinaInstitute of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, ChinaGuangdong Metabolic Disease Research Center of Integrated Chinese and Western Medicine, Guangdong Pharmaceutical University, Guangzhou, ChinaKey Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China, Guangzhou, ChinaGuangdong TCM Key Laboratory for Metabolic Diseases, Guangdong Pharmaceutical University, Guangzhou, ChinaInstitute of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, ChinaGuangdong Metabolic Disease Research Center of Integrated Chinese and Western Medicine, Guangdong Pharmaceutical University, Guangzhou, ChinaKey Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China, Guangzhou, ChinaGuangdong TCM Key Laboratory for Metabolic Diseases, Guangdong Pharmaceutical University, Guangzhou, ChinaInstitute of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, ChinaGuangdong Metabolic Disease Research Center of Integrated Chinese and Western Medicine, Guangdong Pharmaceutical University, Guangzhou, ChinaKey Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China, Guangzhou, ChinaGuangdong TCM Key Laboratory for Metabolic Diseases, Guangdong Pharmaceutical University, Guangzhou, ChinaInstitute of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, ChinaHypertension is frequently comorbid with the disorders of glucose and lipid metabolism. The increased intakes of fructose and salt contribute to the development of hypertension and related metabolic disorders, which are closely associated with gut dysbiosis. Fufang-Zhenzhu-Tiaozhi capsule (FTZ), a traditional Chinese patent medicine commonly used in clinical practice, has recently emerged as a promising drug candidate for metabolic diseases. In this study, FTZ treatment is identified as attenuating blood pressure increase and improving the metabolism of lipid and uric acid in high-fructose and high-salt (HFS) diet-fed rats. FTZ also substantially alleviated renal fibrosis and the mRNA expression of inflammation cytokines, NADPH oxidases, and the renin–angiotensin system in the renal cortex. 16S rRNA sequencing of fecal samples revealed that FTZ restored HFS-induced gut dysbiosis, seen as increased intestinal microbial richness and diversity. Furthermore, fecal microbiota transplantation also achieved similar therapeutic effects and alterations in gut microbiota profile induced by FTZ. Taken together, this study highlights the efficacy of FTZ in attenuating HFS-induced hypertension and related metabolic disorders and renal injury. The antihypertensive effect is associated with the modulation of gut microbiota.https://www.frontiersin.org/articles/10.3389/fcimb.2022.854849/fullhypertensiongut microbiotametabolic disorderFufang-Zhenzhu-Tiaozhi capsulefecal microbiota transplantation |
| spellingShingle | Zhe Chen Zhe Chen Zhe Chen Zhe Chen Zhe Chen Bin Yang Bin Yang Bin Yang Bin Yang Zhen Wang Zhen Wang Zhen Wang Zhen Wang Xianglu Rong Xianglu Rong Xianglu Rong Xianglu Rong Qing Zhu Qing Zhu Qing Zhu Qing Zhu Jiao Guo Jiao Guo Jiao Guo Jiao Guo Modulation of the Gut Microbiota by Fufang-Zhenzhu-Tiaozhi Capsule Attenuates Hypertension Induced by a High-Fructose and High-Salt Diet Frontiers in Cellular and Infection Microbiology hypertension gut microbiota metabolic disorder Fufang-Zhenzhu-Tiaozhi capsule fecal microbiota transplantation |
| title | Modulation of the Gut Microbiota by Fufang-Zhenzhu-Tiaozhi Capsule Attenuates Hypertension Induced by a High-Fructose and High-Salt Diet |
| title_full | Modulation of the Gut Microbiota by Fufang-Zhenzhu-Tiaozhi Capsule Attenuates Hypertension Induced by a High-Fructose and High-Salt Diet |
| title_fullStr | Modulation of the Gut Microbiota by Fufang-Zhenzhu-Tiaozhi Capsule Attenuates Hypertension Induced by a High-Fructose and High-Salt Diet |
| title_full_unstemmed | Modulation of the Gut Microbiota by Fufang-Zhenzhu-Tiaozhi Capsule Attenuates Hypertension Induced by a High-Fructose and High-Salt Diet |
| title_short | Modulation of the Gut Microbiota by Fufang-Zhenzhu-Tiaozhi Capsule Attenuates Hypertension Induced by a High-Fructose and High-Salt Diet |
| title_sort | modulation of the gut microbiota by fufang zhenzhu tiaozhi capsule attenuates hypertension induced by a high fructose and high salt diet |
| topic | hypertension gut microbiota metabolic disorder Fufang-Zhenzhu-Tiaozhi capsule fecal microbiota transplantation |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2022.854849/full |
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