Characterizing Dietary Advanced Glycation End-Product (dAGE) Exposure and the Relationship to Colorectal Adenoma Recurrence: A Secondary Analysis
Limited studies have evaluated the association between dietary advanced glycation end-product AGE (dAGEs) intake and cancer risk; however, no studies have addressed adenoma risk or recurrence. The objective of this study was to determine an association between dietary AGEs and adenoma recurrence. A...
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| Format: | Article |
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MDPI AG
2023-02-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/5/1126 |
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| author | Maren Sfeir Elizabeth T. Jacobs Lindsay N. Kohler Susan E. Steck Angela K. Yung Cynthia A. Thomson |
| author_facet | Maren Sfeir Elizabeth T. Jacobs Lindsay N. Kohler Susan E. Steck Angela K. Yung Cynthia A. Thomson |
| author_sort | Maren Sfeir |
| collection | DOAJ |
| description | Limited studies have evaluated the association between dietary advanced glycation end-product AGE (dAGEs) intake and cancer risk; however, no studies have addressed adenoma risk or recurrence. The objective of this study was to determine an association between dietary AGEs and adenoma recurrence. A secondary analysis was conducted using an existing dataset from a pooled sample of participants in two adenoma prevention trials. Participants completed a baseline Arizona Food Frequency Questionnaire (AFFQ) to estimate AGE exposure. N<sup>Ɛ</sup>- carboxymethyl-lysine (CML)-AGE values were assigned to quantify foods in the AFFQ using a published AGE database, and participants’ exposure was evaluated as a CML-AGE (kU/1000 kcal) intake. Regression models were run to determine the relationship between CML-AGE intake and adenoma recurrence. The sample included 1976 adults with a mean age of 67.2 y ± 7.34. The average CML-AGE intake was 5251.1 ± 1633.1 (kU/1000 kcal), ranging between 4960 and 17032.4 (kU/1000 kcal). A higher intake of CML-AGE had no significant association with the odds of adenoma recurrence [OR(95% CI) = 1.02 (0.71,1.48)] compared to participants with a lower intake. In this sample, CML-AGE intake was not associated with adenoma recurrence. Future research is needed and should be expanded to examine the intake of different types of dAGEs with consideration for the direct measurement of AGE. |
| first_indexed | 2024-03-11T07:14:15Z |
| format | Article |
| id | doaj.art-1987036f225543e4b52c987063ea1371 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T07:14:15Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-1987036f225543e4b52c987063ea13712023-11-17T08:19:56ZengMDPI AGNutrients2072-66432023-02-01155112610.3390/nu15051126Characterizing Dietary Advanced Glycation End-Product (dAGE) Exposure and the Relationship to Colorectal Adenoma Recurrence: A Secondary AnalysisMaren Sfeir0Elizabeth T. Jacobs1Lindsay N. Kohler2Susan E. Steck3Angela K. Yung4Cynthia A. Thomson5School of Nutritional Science and Wellness, University of Arizona, 1177 E 4th St, Tucson, AZ 85719, USACollege of Mel and Enid Zuckerman, School of Public Health, University of Arizona, Tucson, AZ 85724, USACollege of Mel and Enid Zuckerman, School of Public Health, University of Arizona, Tucson, AZ 85724, USASchool of Public Health, University of South Carolina Arnold, Columbia, SC 29208, USAUniversity of Arizona Cancer Center, University of Arizona, Tucson, AZ 85724, USACollege of Mel and Enid Zuckerman, School of Public Health, University of Arizona, Tucson, AZ 85724, USALimited studies have evaluated the association between dietary advanced glycation end-product AGE (dAGEs) intake and cancer risk; however, no studies have addressed adenoma risk or recurrence. The objective of this study was to determine an association between dietary AGEs and adenoma recurrence. A secondary analysis was conducted using an existing dataset from a pooled sample of participants in two adenoma prevention trials. Participants completed a baseline Arizona Food Frequency Questionnaire (AFFQ) to estimate AGE exposure. N<sup>Ɛ</sup>- carboxymethyl-lysine (CML)-AGE values were assigned to quantify foods in the AFFQ using a published AGE database, and participants’ exposure was evaluated as a CML-AGE (kU/1000 kcal) intake. Regression models were run to determine the relationship between CML-AGE intake and adenoma recurrence. The sample included 1976 adults with a mean age of 67.2 y ± 7.34. The average CML-AGE intake was 5251.1 ± 1633.1 (kU/1000 kcal), ranging between 4960 and 17032.4 (kU/1000 kcal). A higher intake of CML-AGE had no significant association with the odds of adenoma recurrence [OR(95% CI) = 1.02 (0.71,1.48)] compared to participants with a lower intake. In this sample, CML-AGE intake was not associated with adenoma recurrence. Future research is needed and should be expanded to examine the intake of different types of dAGEs with consideration for the direct measurement of AGE.https://www.mdpi.com/2072-6643/15/5/1126adenomadietary advanced glycation end-productscolorectal cancercancersecondary analysis |
| spellingShingle | Maren Sfeir Elizabeth T. Jacobs Lindsay N. Kohler Susan E. Steck Angela K. Yung Cynthia A. Thomson Characterizing Dietary Advanced Glycation End-Product (dAGE) Exposure and the Relationship to Colorectal Adenoma Recurrence: A Secondary Analysis Nutrients adenoma dietary advanced glycation end-products colorectal cancer cancer secondary analysis |
| title | Characterizing Dietary Advanced Glycation End-Product (dAGE) Exposure and the Relationship to Colorectal Adenoma Recurrence: A Secondary Analysis |
| title_full | Characterizing Dietary Advanced Glycation End-Product (dAGE) Exposure and the Relationship to Colorectal Adenoma Recurrence: A Secondary Analysis |
| title_fullStr | Characterizing Dietary Advanced Glycation End-Product (dAGE) Exposure and the Relationship to Colorectal Adenoma Recurrence: A Secondary Analysis |
| title_full_unstemmed | Characterizing Dietary Advanced Glycation End-Product (dAGE) Exposure and the Relationship to Colorectal Adenoma Recurrence: A Secondary Analysis |
| title_short | Characterizing Dietary Advanced Glycation End-Product (dAGE) Exposure and the Relationship to Colorectal Adenoma Recurrence: A Secondary Analysis |
| title_sort | characterizing dietary advanced glycation end product dage exposure and the relationship to colorectal adenoma recurrence a secondary analysis |
| topic | adenoma dietary advanced glycation end-products colorectal cancer cancer secondary analysis |
| url | https://www.mdpi.com/2072-6643/15/5/1126 |
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