Intestinal transport and metabolism of bile acids
In addition to their classical roles as detergents to aid in the process of digestion, bile acids have been identified as important signaling molecules that function through various nuclear and G protein-coupled receptors to regulate a myriad of cellular and molecular functions across both metabolic...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2015-06-01
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| Series: | Journal of Lipid Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520317211 |
| _version_ | 1829512585850912768 |
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| author | Paul A. Dawson Saul J. Karpen |
| author_facet | Paul A. Dawson Saul J. Karpen |
| author_sort | Paul A. Dawson |
| collection | DOAJ |
| description | In addition to their classical roles as detergents to aid in the process of digestion, bile acids have been identified as important signaling molecules that function through various nuclear and G protein-coupled receptors to regulate a myriad of cellular and molecular functions across both metabolic and nonmetabolic pathways. Signaling via these pathways will vary depending on the tissue and the concentration and chemical structure of the bile acid species. Important determinants of the size and composition of the bile acid pool are their efficient enterohepatic recirculation, their host and microbial metabolism, and the homeostatic feedback mechanisms connecting hepatocytes, enterocytes, and the luminal microbiota. This review focuses on the mammalian intestine, discussing the physiology of bile acid transport, the metabolism of bile acids in the gut, and new developments in our understanding of how intestinal metabolism, particularly by the gut microbiota, affects bile acid signaling. |
| first_indexed | 2024-12-16T12:45:08Z |
| format | Article |
| id | doaj.art-1988b7b53d574159bf25af0d04c0b339 |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-16T12:45:08Z |
| publishDate | 2015-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-1988b7b53d574159bf25af0d04c0b3392022-12-21T22:31:19ZengElsevierJournal of Lipid Research0022-22752015-06-0156610851099Intestinal transport and metabolism of bile acidsPaul A. Dawson0Saul J. Karpen1To whom correspondence should be addressed.; Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Emory University, Atlanta, GA 30322Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Emory University, Atlanta, GA 30322In addition to their classical roles as detergents to aid in the process of digestion, bile acids have been identified as important signaling molecules that function through various nuclear and G protein-coupled receptors to regulate a myriad of cellular and molecular functions across both metabolic and nonmetabolic pathways. Signaling via these pathways will vary depending on the tissue and the concentration and chemical structure of the bile acid species. Important determinants of the size and composition of the bile acid pool are their efficient enterohepatic recirculation, their host and microbial metabolism, and the homeostatic feedback mechanisms connecting hepatocytes, enterocytes, and the luminal microbiota. This review focuses on the mammalian intestine, discussing the physiology of bile acid transport, the metabolism of bile acids in the gut, and new developments in our understanding of how intestinal metabolism, particularly by the gut microbiota, affects bile acid signaling.http://www.sciencedirect.com/science/article/pii/S0022227520317211enterohepatic circulationtransportersnuclear receptorsmicrobiome |
| spellingShingle | Paul A. Dawson Saul J. Karpen Intestinal transport and metabolism of bile acids Journal of Lipid Research enterohepatic circulation transporters nuclear receptors microbiome |
| title | Intestinal transport and metabolism of bile acids |
| title_full | Intestinal transport and metabolism of bile acids |
| title_fullStr | Intestinal transport and metabolism of bile acids |
| title_full_unstemmed | Intestinal transport and metabolism of bile acids |
| title_short | Intestinal transport and metabolism of bile acids |
| title_sort | intestinal transport and metabolism of bile acids |
| topic | enterohepatic circulation transporters nuclear receptors microbiome |
| url | http://www.sciencedirect.com/science/article/pii/S0022227520317211 |
| work_keys_str_mv | AT pauladawson intestinaltransportandmetabolismofbileacids AT sauljkarpen intestinaltransportandmetabolismofbileacids |