Correlation between QRS Complex Changes and Cardiac Iron Overload in Beta Thalassemia Major Patients Using T2*MRI
Background and purpose: Cardiac magnetic resonance imaging (MRI) is a costly method to assess cardiac iron overload. The presence of fragmented QRS (fQRS) indicates changes due to iron overload in cardiac tissue. The aim of this study was to evaluate the correlation between fQRS and cardiac iron ove...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Mazandaran University of Medical Sciences
2021-04-01
|
| Series: | Journal of Mazandaran University of Medical Sciences |
| Subjects: | |
| Online Access: | http://jmums.mazums.ac.ir/article-1-15488-en.html |
| _version_ | 1797943979682037760 |
|---|---|
| author | Mohammad Amini Navidreza Mashayekhi Bahman Sadeghi Aziz Eghbali Yazdan Ghandi |
| author_facet | Mohammad Amini Navidreza Mashayekhi Bahman Sadeghi Aziz Eghbali Yazdan Ghandi |
| author_sort | Mohammad Amini |
| collection | DOAJ |
| description | Background and purpose: Cardiac magnetic resonance imaging (MRI) is a costly method to assess cardiac iron overload. The presence of fragmented QRS (fQRS) indicates changes due to iron overload in cardiac tissue. The aim of this study was to evaluate the correlation between fQRS and cardiac iron overload using cardiac MRI in patients with β-thalassemia major (β-TM).
Materials and methods: This analytical cross-sectional study was conducted in 40 β-TM patients admitted to Arak Amir-Kabir Hospital, Iran 2018-2019. Cardiac T2* MRI was performed and values of less than 20 ms were considered as cardiac iron overload. The patients were divided into two groups (<20 and >20 ms). The presence of fQRS was assessed on 12-lead surface electrocardiogram (ECG) and compared between two groups.
Results: There was a positive correlation between T2*MRI and serum ferritin (r= 0.041, P=0.657) and hemoglobin levels (r=0.057, P=0.540). The mean T2*MRI in patients with fQRS (18.43±7.24) was significantly lower than patients without fQRS (26.47±6.15) (P=0.001). We found a negative correlation between T2*MRI and fQRS (r= -0.048, P=0.001).
Conclusion: The presence of fQRS on ECGs could be a good predictor of cardiac iron overload in β-TM patients. It is believed that fQRS can indicate this change in electrocardiography and shows the need for more accurate monitoring for cardiac overload and aggressive chelation therapy. |
| first_indexed | 2024-04-10T20:32:31Z |
| format | Article |
| id | doaj.art-198a93f7d2a9412aa518aa38f45f37f8 |
| institution | Directory Open Access Journal |
| issn | 1735-9260 1735-9279 |
| language | English |
| last_indexed | 2024-04-10T20:32:31Z |
| publishDate | 2021-04-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Journal of Mazandaran University of Medical Sciences |
| spelling | doaj.art-198a93f7d2a9412aa518aa38f45f37f82023-01-25T05:12:56ZengMazandaran University of Medical SciencesJournal of Mazandaran University of Medical Sciences1735-92601735-92792021-04-01311951218Correlation between QRS Complex Changes and Cardiac Iron Overload in Beta Thalassemia Major Patients Using T2*MRIMohammad Amini0Navidreza Mashayekhi1Bahman Sadeghi2Aziz Eghbali3Yazdan Ghandi4 General Practitioner, Arak, Iran MSc in Biotechnology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran 3 Associate Professor, Department of Community Medicine, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran Associate Professor, Department of Pediatrics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Associate Professor, Department of Pediatrics, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran Background and purpose: Cardiac magnetic resonance imaging (MRI) is a costly method to assess cardiac iron overload. The presence of fragmented QRS (fQRS) indicates changes due to iron overload in cardiac tissue. The aim of this study was to evaluate the correlation between fQRS and cardiac iron overload using cardiac MRI in patients with β-thalassemia major (β-TM). Materials and methods: This analytical cross-sectional study was conducted in 40 β-TM patients admitted to Arak Amir-Kabir Hospital, Iran 2018-2019. Cardiac T2* MRI was performed and values of less than 20 ms were considered as cardiac iron overload. The patients were divided into two groups (<20 and >20 ms). The presence of fQRS was assessed on 12-lead surface electrocardiogram (ECG) and compared between two groups. Results: There was a positive correlation between T2*MRI and serum ferritin (r= 0.041, P=0.657) and hemoglobin levels (r=0.057, P=0.540). The mean T2*MRI in patients with fQRS (18.43±7.24) was significantly lower than patients without fQRS (26.47±6.15) (P=0.001). We found a negative correlation between T2*MRI and fQRS (r= -0.048, P=0.001). Conclusion: The presence of fQRS on ECGs could be a good predictor of cardiac iron overload in β-TM patients. It is believed that fQRS can indicate this change in electrocardiography and shows the need for more accurate monitoring for cardiac overload and aggressive chelation therapy.http://jmums.mazums.ac.ir/article-1-15488-en.htmlarrhythmiabeta-thalassemiairon overloadfragmented qrs |
| spellingShingle | Mohammad Amini Navidreza Mashayekhi Bahman Sadeghi Aziz Eghbali Yazdan Ghandi Correlation between QRS Complex Changes and Cardiac Iron Overload in Beta Thalassemia Major Patients Using T2*MRI Journal of Mazandaran University of Medical Sciences arrhythmia beta-thalassemia iron overload fragmented qrs |
| title | Correlation between QRS Complex Changes and Cardiac Iron Overload in Beta Thalassemia Major Patients Using T2*MRI |
| title_full | Correlation between QRS Complex Changes and Cardiac Iron Overload in Beta Thalassemia Major Patients Using T2*MRI |
| title_fullStr | Correlation between QRS Complex Changes and Cardiac Iron Overload in Beta Thalassemia Major Patients Using T2*MRI |
| title_full_unstemmed | Correlation between QRS Complex Changes and Cardiac Iron Overload in Beta Thalassemia Major Patients Using T2*MRI |
| title_short | Correlation between QRS Complex Changes and Cardiac Iron Overload in Beta Thalassemia Major Patients Using T2*MRI |
| title_sort | correlation between qrs complex changes and cardiac iron overload in beta thalassemia major patients using t2 mri |
| topic | arrhythmia beta-thalassemia iron overload fragmented qrs |
| url | http://jmums.mazums.ac.ir/article-1-15488-en.html |
| work_keys_str_mv | AT mohammadamini correlationbetweenqrscomplexchangesandcardiacironoverloadinbetathalassemiamajorpatientsusingt2mri AT navidrezamashayekhi correlationbetweenqrscomplexchangesandcardiacironoverloadinbetathalassemiamajorpatientsusingt2mri AT bahmansadeghi correlationbetweenqrscomplexchangesandcardiacironoverloadinbetathalassemiamajorpatientsusingt2mri AT azizeghbali correlationbetweenqrscomplexchangesandcardiacironoverloadinbetathalassemiamajorpatientsusingt2mri AT yazdanghandi correlationbetweenqrscomplexchangesandcardiacironoverloadinbetathalassemiamajorpatientsusingt2mri |