Cardiac functions and pericardial thickness changes in familial Mediterranean fever patients
Abstract Background The goal of the study is to ascertain how the pericardium and heart functions alter in patients with familial Mediterranean fever (FMF) both during the acute phase and the period of subclinical inflammation. Methods During the study, 99 patients diagnosed with FMF (35 of whom wer...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2024-02-01
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| Series: | Egyptian Rheumatology and Rehabilitation |
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| Online Access: | https://doi.org/10.1186/s43166-024-00243-y |
| _version_ | 1797274350537146368 |
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| author | Yasemin Demir Yiğit Özlem Karakuş Karatoprak Elif Güzelsoy Ay Muhammed Karabulut Erdal Yılmaz Metin Kaya Gürgöze |
| author_facet | Yasemin Demir Yiğit Özlem Karakuş Karatoprak Elif Güzelsoy Ay Muhammed Karabulut Erdal Yılmaz Metin Kaya Gürgöze |
| author_sort | Yasemin Demir Yiğit |
| collection | DOAJ |
| description | Abstract Background The goal of the study is to ascertain how the pericardium and heart functions alter in patients with familial Mediterranean fever (FMF) both during the acute phase and the period of subclinical inflammation. Methods During the study, 99 patients diagnosed with FMF (35 of whom were in an FMF attack period) were recruited to this study, and 24 completely healthy children in the same age group—who did not have FMF and had not any cardiac condition that applied to visit the pediatric cardiology outpatient clinic for routine follow-up—were included as the control group. Results In patients with FMF, there was no discernible relationship between genetic abnormalities and pericardial thickness (p > 0.05). A significant difference was not observed in the diastolic and systolic cardiac function values between the control group and the FMF patients, with the exception of the parameters related to ejection time (ET), contraction time (IVCT), and relaxation time (IVRT). It was observed that pericardial thickness was greater in FMF patients than in study participants who did not have FMF, and this difference is statistically significant (p < 0.05). Conclusions It was determined that the effects of cardiac inflammation continued in children with FMF, even if they were asymptomatic. Therefore, it should be part of the follow-ups. Key points • In our study, cardiac functions and pericardial thickening of 99 FMF patients with and without attack were prospectively investigated. • In ongoing follow-up of patients with FMF, we found that inflammation, which affects all serosas, also affects the pericardium during the attract and nonattack phase. • We believe that cardiac functions, including the status of the pericardium, should be monitored as part of the long-term follow-up of FMF. |
| first_indexed | 2024-03-07T14:57:11Z |
| format | Article |
| id | doaj.art-198acb1ba85a4a8b910c85b2ab2deda8 |
| institution | Directory Open Access Journal |
| issn | 2090-3235 |
| language | English |
| last_indexed | 2024-03-07T14:57:11Z |
| publishDate | 2024-02-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Egyptian Rheumatology and Rehabilitation |
| spelling | doaj.art-198acb1ba85a4a8b910c85b2ab2deda82024-03-05T19:21:13ZengSpringerOpenEgyptian Rheumatology and Rehabilitation2090-32352024-02-015111710.1186/s43166-024-00243-yCardiac functions and pericardial thickness changes in familial Mediterranean fever patientsYasemin Demir Yiğit0Özlem Karakuş Karatoprak1Elif Güzelsoy Ay2Muhammed Karabulut3Erdal Yılmaz4Metin Kaya Gürgöze5Rheumatology Clinic, Department of Pediatrics, Fırat University Faculty of MedicineDepartment of Pediatrics, Gazi Yasargil Training and Research HospitalRheumatology Clinic, Department of Pediatrics, Fırat University Faculty of MedicineRheumatology Clinic, Department of Pediatrics, Fırat University Faculty of MedicineRheumatology Clinic, Department of Pediatrics, Fırat University Faculty of MedicineRheumatology Clinic, Department of Pediatrics, Fırat University Faculty of MedicineAbstract Background The goal of the study is to ascertain how the pericardium and heart functions alter in patients with familial Mediterranean fever (FMF) both during the acute phase and the period of subclinical inflammation. Methods During the study, 99 patients diagnosed with FMF (35 of whom were in an FMF attack period) were recruited to this study, and 24 completely healthy children in the same age group—who did not have FMF and had not any cardiac condition that applied to visit the pediatric cardiology outpatient clinic for routine follow-up—were included as the control group. Results In patients with FMF, there was no discernible relationship between genetic abnormalities and pericardial thickness (p > 0.05). A significant difference was not observed in the diastolic and systolic cardiac function values between the control group and the FMF patients, with the exception of the parameters related to ejection time (ET), contraction time (IVCT), and relaxation time (IVRT). It was observed that pericardial thickness was greater in FMF patients than in study participants who did not have FMF, and this difference is statistically significant (p < 0.05). Conclusions It was determined that the effects of cardiac inflammation continued in children with FMF, even if they were asymptomatic. Therefore, it should be part of the follow-ups. Key points • In our study, cardiac functions and pericardial thickening of 99 FMF patients with and without attack were prospectively investigated. • In ongoing follow-up of patients with FMF, we found that inflammation, which affects all serosas, also affects the pericardium during the attract and nonattack phase. • We believe that cardiac functions, including the status of the pericardium, should be monitored as part of the long-term follow-up of FMF.https://doi.org/10.1186/s43166-024-00243-yChildrenFMFCardiac functionsPericardial involvement |
| spellingShingle | Yasemin Demir Yiğit Özlem Karakuş Karatoprak Elif Güzelsoy Ay Muhammed Karabulut Erdal Yılmaz Metin Kaya Gürgöze Cardiac functions and pericardial thickness changes in familial Mediterranean fever patients Egyptian Rheumatology and Rehabilitation Children FMF Cardiac functions Pericardial involvement |
| title | Cardiac functions and pericardial thickness changes in familial Mediterranean fever patients |
| title_full | Cardiac functions and pericardial thickness changes in familial Mediterranean fever patients |
| title_fullStr | Cardiac functions and pericardial thickness changes in familial Mediterranean fever patients |
| title_full_unstemmed | Cardiac functions and pericardial thickness changes in familial Mediterranean fever patients |
| title_short | Cardiac functions and pericardial thickness changes in familial Mediterranean fever patients |
| title_sort | cardiac functions and pericardial thickness changes in familial mediterranean fever patients |
| topic | Children FMF Cardiac functions Pericardial involvement |
| url | https://doi.org/10.1186/s43166-024-00243-y |
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