Low incidence of malignancy in patients with suspected polymyalgia rheumatica or giant cell arteritis, examined with FDG-PET/CT
IntroductionThe need to systematically examine patients suspected of polymyalgia rheumatica (PMR) and giant cell arteritis (GCA) for malignancy is controversial. The aim of this study was to assess the frequency of malignancy in patients with suspected PMR and/or GCA who have been referred to a 2-de...
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1309905/full |
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| author | Tanja Fromberg Gorlen Tanja Fromberg Gorlen Jane Maestri Brittain Mikkel Østergaard Mikkel Østergaard Barbara Malene Fischer Barbara Malene Fischer Uffe Møller Døhn Lene Terslev Lene Terslev |
| author_facet | Tanja Fromberg Gorlen Tanja Fromberg Gorlen Jane Maestri Brittain Mikkel Østergaard Mikkel Østergaard Barbara Malene Fischer Barbara Malene Fischer Uffe Møller Døhn Lene Terslev Lene Terslev |
| author_sort | Tanja Fromberg Gorlen |
| collection | DOAJ |
| description | IntroductionThe need to systematically examine patients suspected of polymyalgia rheumatica (PMR) and giant cell arteritis (GCA) for malignancy is controversial. The aim of this study was to assess the frequency of malignancy in patients with suspected PMR and/or GCA who have been referred to a 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography with computed tomography (FDG-PET/CT) as part of the diagnostic investigation.MethodThe records of all patients referred to FDG-PET/CT from Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup with the suspicion of PMR and/or GCA during a two-year period, were retrospectively reviewed. Data was analyzed with descriptive statistics, and a standard incidence ratio was calculated based on background cancer incidences extracted from the NORDCAN database.Results220 patients were included in the study. Findings suspicious of malignancy were found in 19 of the examinations, and in seven cases (3.2%), malignancy was confirmed. In three out of the seven cases the patients were diagnosed with PMR concomitantly with malignancy. The estimated standardized incidence ratio (SIR) for cancer compared to the background incidence of cancer in Denmark was 1.58 (95% CI 0.63–2.97), i.e., not statistically significant. There were no statistically significant differences in characteristics of the patients that were diagnosed with malignancy compared with those that were not.ConclusionThe frequency of malignancy in this cohort of patients with suspected PMR/GCA who underwent PET/CT was low. Our results, though based on a small cohort, do not suggest that all patients with suspected PMR/GCA should systematically be examined with FDG-PET/CT for excluding malignancy. |
| first_indexed | 2024-03-07T23:20:35Z |
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| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-03-07T23:20:35Z |
| publishDate | 2024-02-01 |
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| series | Frontiers in Medicine |
| spelling | doaj.art-198b269d16bd49d7b395590c44e3ecde2024-02-21T05:50:37ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2024-02-011110.3389/fmed.2024.13099051309905Low incidence of malignancy in patients with suspected polymyalgia rheumatica or giant cell arteritis, examined with FDG-PET/CTTanja Fromberg Gorlen0Tanja Fromberg Gorlen1Jane Maestri Brittain2Mikkel Østergaard3Mikkel Østergaard4Barbara Malene Fischer5Barbara Malene Fischer6Uffe Møller Døhn7Lene Terslev8Lene Terslev9Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Copenhagen University Hospital – Rigshospitalet Glostrup, Copenhagen, DenmarkDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, The University of Copenhagen, Copenhagen, DenmarkDepartment of Clinical Physiology & Nuclear Medicine, Copenhagen University Hospital – Rigshospitalet, Copenhagen, DenmarkCopenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Copenhagen University Hospital – Rigshospitalet Glostrup, Copenhagen, DenmarkDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, The University of Copenhagen, Copenhagen, DenmarkDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, The University of Copenhagen, Copenhagen, DenmarkDepartment of Clinical Physiology & Nuclear Medicine, Copenhagen University Hospital – Rigshospitalet, Copenhagen, DenmarkCopenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Copenhagen University Hospital – Rigshospitalet Glostrup, Copenhagen, DenmarkCopenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Copenhagen University Hospital – Rigshospitalet Glostrup, Copenhagen, DenmarkDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, The University of Copenhagen, Copenhagen, DenmarkIntroductionThe need to systematically examine patients suspected of polymyalgia rheumatica (PMR) and giant cell arteritis (GCA) for malignancy is controversial. The aim of this study was to assess the frequency of malignancy in patients with suspected PMR and/or GCA who have been referred to a 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography with computed tomography (FDG-PET/CT) as part of the diagnostic investigation.MethodThe records of all patients referred to FDG-PET/CT from Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup with the suspicion of PMR and/or GCA during a two-year period, were retrospectively reviewed. Data was analyzed with descriptive statistics, and a standard incidence ratio was calculated based on background cancer incidences extracted from the NORDCAN database.Results220 patients were included in the study. Findings suspicious of malignancy were found in 19 of the examinations, and in seven cases (3.2%), malignancy was confirmed. In three out of the seven cases the patients were diagnosed with PMR concomitantly with malignancy. The estimated standardized incidence ratio (SIR) for cancer compared to the background incidence of cancer in Denmark was 1.58 (95% CI 0.63–2.97), i.e., not statistically significant. There were no statistically significant differences in characteristics of the patients that were diagnosed with malignancy compared with those that were not.ConclusionThe frequency of malignancy in this cohort of patients with suspected PMR/GCA who underwent PET/CT was low. Our results, though based on a small cohort, do not suggest that all patients with suspected PMR/GCA should systematically be examined with FDG-PET/CT for excluding malignancy.https://www.frontiersin.org/articles/10.3389/fmed.2024.1309905/fullpolymyalgia rheumatica (PMR)giant cell arteritis (GCA)FDG (18F-fluorodeoxyglucose)-PET/CTmalignancydiagnostic examination |
| spellingShingle | Tanja Fromberg Gorlen Tanja Fromberg Gorlen Jane Maestri Brittain Mikkel Østergaard Mikkel Østergaard Barbara Malene Fischer Barbara Malene Fischer Uffe Møller Døhn Lene Terslev Lene Terslev Low incidence of malignancy in patients with suspected polymyalgia rheumatica or giant cell arteritis, examined with FDG-PET/CT Frontiers in Medicine polymyalgia rheumatica (PMR) giant cell arteritis (GCA) FDG (18F-fluorodeoxyglucose)-PET/CT malignancy diagnostic examination |
| title | Low incidence of malignancy in patients with suspected polymyalgia rheumatica or giant cell arteritis, examined with FDG-PET/CT |
| title_full | Low incidence of malignancy in patients with suspected polymyalgia rheumatica or giant cell arteritis, examined with FDG-PET/CT |
| title_fullStr | Low incidence of malignancy in patients with suspected polymyalgia rheumatica or giant cell arteritis, examined with FDG-PET/CT |
| title_full_unstemmed | Low incidence of malignancy in patients with suspected polymyalgia rheumatica or giant cell arteritis, examined with FDG-PET/CT |
| title_short | Low incidence of malignancy in patients with suspected polymyalgia rheumatica or giant cell arteritis, examined with FDG-PET/CT |
| title_sort | low incidence of malignancy in patients with suspected polymyalgia rheumatica or giant cell arteritis examined with fdg pet ct |
| topic | polymyalgia rheumatica (PMR) giant cell arteritis (GCA) FDG (18F-fluorodeoxyglucose)-PET/CT malignancy diagnostic examination |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1309905/full |
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