Hypoxic Effects on Matrix Metalloproteinases’ Expression in the Tumor Microenvironment and Therapeutic Perspectives

Hypoxic Effects on Matrix Metalloproteinases’ Expression in the Tumor Microenvironment and Therapeutic Perspectives

The tumor microenvironment (TME) is characterized by an acidic pH and low oxygen concentrations. Hypoxia induces neoplastic cell evasion of the immune surveillance, rapid DNA repair, metabolic reprogramming, and metastasis, mainly as a response to the hypoxic inducible factors (HIFs). Likewise, canc...

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Bibliographic Details
Main Authors: Georgina Gonzalez-Avila, Bettina Sommer, Edgar Flores-Soto, Arnoldo Aquino-Galvez
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:International Journal of Molecular Sciences
Subjects:
cancer treatment
HIFs
hypoxia
matrix metalloproteinases
nanotechnology
tumor microenvironment
Online Access:https://www.mdpi.com/1422-0067/24/23/16887

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