The relationship between long non-coding gene CASC21 polymorphisms and cervical cancer
ABSTRACTBackground CASC21 was reported to be a hotspot gene in cervical cancer. The relationship between CASC21 genetic polymorphisms and cervical cancer has not been reported. Genetic factors influence the occurrence of cervical cancer. Thus, we explored the correlation between CASC21 polymorphisms...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Cancer Biology & Therapy |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/15384047.2024.2322207 |
| _version_ | 1797266058124460032 |
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| author | Lili Han Jing Liu Mireayi Shataer Chengyong Wu Mayinuer Niyazi |
| author_facet | Lili Han Jing Liu Mireayi Shataer Chengyong Wu Mayinuer Niyazi |
| author_sort | Lili Han |
| collection | DOAJ |
| description | ABSTRACTBackground CASC21 was reported to be a hotspot gene in cervical cancer. The relationship between CASC21 genetic polymorphisms and cervical cancer has not been reported. Genetic factors influence the occurrence of cervical cancer. Thus, we explored the correlation between CASC21 polymorphisms and cervical cancer.Methods A total of 973 participants within 494 cervical cancer cases and 479 healthy controls were recruited. Five single nucleotide polymorphisms (SNPs) in the CASC21 gene were genotyped using the Agena MassARRAY platform. Chi-squared test, logistic regression analysis, odds ratio (OR), multifactor dimensionality reduction (MDR), and 95% confidence interval (95%CI) were used for data analysis.Results In the overall analysis, rs16902094 (p = .014, OR = 1.86, 95% CI = 1.12–3.08) and rs16902104 (p = .014, OR = 1.86, 95% CI = 1.12–3.09) had the risk-increasing correlation with the occurrence of cervical cancer. Stratification analysis showed that rs16902094 and rs16902104 were still associated with cervical cancer risk in the subgroups with age > 51, BMI < 24 kg/m2, smokers, and patients with cervical squamous cell carcinoma. MDR analysis displayed that rs16902094 (.49%) and rs16902104 (.52%) were the main influential attribution factor for cervical cancer risk.Conclusion Our finding firstly determined that two CASC21 SNPs (rs16902094, rs16902104) were associated with an increased risk of cervical cancer, which adds to our knowledge regarding the effect of CASC21 on cervical carcinogenesis. |
| first_indexed | 2024-04-25T00:54:39Z |
| format | Article |
| id | doaj.art-198f36531a2240d39b05a94cdf952d00 |
| institution | Directory Open Access Journal |
| issn | 1538-4047 1555-8576 |
| language | English |
| last_indexed | 2024-04-25T00:54:39Z |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Cancer Biology & Therapy |
| spelling | doaj.art-198f36531a2240d39b05a94cdf952d002024-03-11T10:18:56ZengTaylor & Francis GroupCancer Biology & Therapy1538-40471555-85762024-12-0125110.1080/15384047.2024.2322207The relationship between long non-coding gene CASC21 polymorphisms and cervical cancerLili Han0Jing Liu1Mireayi Shataer2Chengyong Wu3Mayinuer Niyazi4Department of Gynecology, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumchi, Xinjiang, ChinaDepartment of Gynecology, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumchi, Xinjiang, ChinaDepartment of Gynecology, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumchi, Xinjiang, ChinaDepartment of Gynecology, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumchi, Xinjiang, ChinaDepartment of Gynecology, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumchi, Xinjiang, ChinaABSTRACTBackground CASC21 was reported to be a hotspot gene in cervical cancer. The relationship between CASC21 genetic polymorphisms and cervical cancer has not been reported. Genetic factors influence the occurrence of cervical cancer. Thus, we explored the correlation between CASC21 polymorphisms and cervical cancer.Methods A total of 973 participants within 494 cervical cancer cases and 479 healthy controls were recruited. Five single nucleotide polymorphisms (SNPs) in the CASC21 gene were genotyped using the Agena MassARRAY platform. Chi-squared test, logistic regression analysis, odds ratio (OR), multifactor dimensionality reduction (MDR), and 95% confidence interval (95%CI) were used for data analysis.Results In the overall analysis, rs16902094 (p = .014, OR = 1.86, 95% CI = 1.12–3.08) and rs16902104 (p = .014, OR = 1.86, 95% CI = 1.12–3.09) had the risk-increasing correlation with the occurrence of cervical cancer. Stratification analysis showed that rs16902094 and rs16902104 were still associated with cervical cancer risk in the subgroups with age > 51, BMI < 24 kg/m2, smokers, and patients with cervical squamous cell carcinoma. MDR analysis displayed that rs16902094 (.49%) and rs16902104 (.52%) were the main influential attribution factor for cervical cancer risk.Conclusion Our finding firstly determined that two CASC21 SNPs (rs16902094, rs16902104) were associated with an increased risk of cervical cancer, which adds to our knowledge regarding the effect of CASC21 on cervical carcinogenesis.https://www.tandfonline.com/doi/10.1080/15384047.2024.2322207Cervical cancergenetic polymorphismCASC21 |
| spellingShingle | Lili Han Jing Liu Mireayi Shataer Chengyong Wu Mayinuer Niyazi The relationship between long non-coding gene CASC21 polymorphisms and cervical cancer Cancer Biology & Therapy Cervical cancer genetic polymorphism CASC21 |
| title | The relationship between long non-coding gene CASC21 polymorphisms and cervical cancer |
| title_full | The relationship between long non-coding gene CASC21 polymorphisms and cervical cancer |
| title_fullStr | The relationship between long non-coding gene CASC21 polymorphisms and cervical cancer |
| title_full_unstemmed | The relationship between long non-coding gene CASC21 polymorphisms and cervical cancer |
| title_short | The relationship between long non-coding gene CASC21 polymorphisms and cervical cancer |
| title_sort | relationship between long non coding gene casc21 polymorphisms and cervical cancer |
| topic | Cervical cancer genetic polymorphism CASC21 |
| url | https://www.tandfonline.com/doi/10.1080/15384047.2024.2322207 |
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