Trimester Specific Reference Ranges for Thyroid Hormones in Pregnancy with Multiples of Median Values
Aim:To establish trimester and population based laboratory-specific rational reference ranges with multiples of median (MoM) values for thyroid hormones.Materials and Methods:The study was conducted in the obstetrics outpatient clinic of a tertiary health care center between April, 2021 and August,...
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| Format: | Article |
| Language: | English |
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Galenos Yayincilik
2022-09-01
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| Series: | Namık Kemal Tıp Dergisi |
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http://namikkemalmedj.com/archives/archive-detail/article-preview/trimester-specific-reference-ranges-for-thyroid-ho/52977
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| author | Arzu Bilge TEKİN Murat YASSA Güldeniz TOKLUCU Derya ERTEN Doğuş BUDAK Bilge DOĞAN TAYMUR Mehmet Akif SARGIN Niyazi TUĞ |
| author_facet | Arzu Bilge TEKİN Murat YASSA Güldeniz TOKLUCU Derya ERTEN Doğuş BUDAK Bilge DOĞAN TAYMUR Mehmet Akif SARGIN Niyazi TUĞ |
| author_sort | Arzu Bilge TEKİN |
| collection | DOAJ |
| description | Aim:To establish trimester and population based laboratory-specific rational reference ranges with multiples of median (MoM) values for thyroid hormones.Materials and Methods:The study was conducted in the obstetrics outpatient clinic of a tertiary health care center between April, 2021 and August, 2021. Healthy pregnant women without any risk factors and antithyroperoxidase positivity were recruited for all three trimesters. Serum thyroid-stimulating hormone (TSH), free thyroxine (FT4) and free triiodo-thyronine (FT3) levels were measured by the electrochemiluminescence technique. Trimester specific reference ranges were determined with 5. and 95. percentiles of TSH, FT3 and FT4 values with MoM values.Results:Overall, 484 healthy pregnant women, including 140 women in their first trimester, 204 women in their second trimester and 140 women in their third trimester were recruited. In the first trimester, 90% (n=126) women’s TSH levels were within the reference limits (0.19-3.25 uIU/mL and 0.19-3.25 MoM) and 11.1% (n=14) had TSH levels above 2.5 uIU/L. For second trimester, 90.2% (n=184) had TSH levels within the reference limits (0.65-3.83 uIU/mL and 0.4-2.36 MoM) and 8.15% (n=15) had TSH levels over 3 uIU/L. In the third trimester, 90.7% (n=127) women’s TSH levels were within reference limits (0.62-3.78 uIU/mL and 0.39-2.35 MoM) and 3.15% (n=4) had TSH levels over 3 uIU/L.Conclusion:Accurate diagnosis and management of thyroid disease for pregnant women is crucial for maternal-fetal outcomes. Established reference ranges for three trimesters in this study were all higher than the recommended fixed ranges of 2011 American Thyroid Association guideline. |
| first_indexed | 2024-04-10T14:18:14Z |
| format | Article |
| id | doaj.art-198f905e72834413a8df7c4379974b97 |
| institution | Directory Open Access Journal |
| issn | 2587-0262 |
| language | English |
| last_indexed | 2024-04-10T14:18:14Z |
| publishDate | 2022-09-01 |
| publisher | Galenos Yayincilik |
| record_format | Article |
| series | Namık Kemal Tıp Dergisi |
| spelling | doaj.art-198f905e72834413a8df7c4379974b972023-02-15T16:09:26ZengGalenos YayincilikNamık Kemal Tıp Dergisi2587-02622022-09-0110327027510.4274/nkmj.galenos.2022.4803013049054Trimester Specific Reference Ranges for Thyroid Hormones in Pregnancy with Multiples of Median ValuesArzu Bilge TEKİN0Murat YASSA1Güldeniz TOKLUCU2Derya ERTEN3Doğuş BUDAK4Bilge DOĞAN TAYMUR5Mehmet Akif SARGIN6Niyazi TUĞ7 Sağlık Bilimleri Üniversitesi, Sancaktepe Şehit Prof. Dr. İlhan Varank Eğitim ve Araştırma Hastanesi, Kadın Hastalıkları ve Doğum Kliniği, İstanbul, Türkiye Bahçeşehir Üniversitesi, VM Medikal Park Maltepe Hastanesi, Kadın Hastalıkları ve Doğum Kliniği, İstanbul, Türkiye Sağlık Bilimleri Üniversitesi, Sancaktepe Şehit Prof. Dr. İlhan Varank Eğitim ve Araştırma Hastanesi, Kadın Hastalıkları ve Doğum Kliniği, İstanbul, Türkiye Sağlık Bilimleri Üniversitesi, Sancaktepe Şehit Prof. Dr. İlhan Varank Eğitim ve Araştırma Hastanesi, Kadın Hastalıkları ve Doğum Kliniği, İstanbul, Türkiye Sağlık Bilimleri Üniversitesi, Sancaktepe Şehit Prof. Dr. İlhan Varank Eğitim ve Araştırma Hastanesi, Kadın Hastalıkları ve Doğum Kliniği, İstanbul, Türkiye Sağlık Bilimleri Üniversitesi, Sancaktepe Şehit Prof. Dr. İlhan Varank Eğitim ve Araştırma Hastanesi, Kadın Hastalıkları ve Doğum Kliniği, İstanbul, Türkiye Bahçeşehir Üniversitesi, VM Medikal Park Maltepe Hastanesi, Kadın Hastalıkları ve Doğum Kliniği, İstanbul, Türkiye Sağlık Bilimleri Üniversitesi, Sancaktepe Şehit Prof. Dr. İlhan Varank Eğitim ve Araştırma Hastanesi, Kadın Hastalıkları ve Doğum Kliniği, İstanbul, Türkiye Aim:To establish trimester and population based laboratory-specific rational reference ranges with multiples of median (MoM) values for thyroid hormones.Materials and Methods:The study was conducted in the obstetrics outpatient clinic of a tertiary health care center between April, 2021 and August, 2021. Healthy pregnant women without any risk factors and antithyroperoxidase positivity were recruited for all three trimesters. Serum thyroid-stimulating hormone (TSH), free thyroxine (FT4) and free triiodo-thyronine (FT3) levels were measured by the electrochemiluminescence technique. Trimester specific reference ranges were determined with 5. and 95. percentiles of TSH, FT3 and FT4 values with MoM values.Results:Overall, 484 healthy pregnant women, including 140 women in their first trimester, 204 women in their second trimester and 140 women in their third trimester were recruited. In the first trimester, 90% (n=126) women’s TSH levels were within the reference limits (0.19-3.25 uIU/mL and 0.19-3.25 MoM) and 11.1% (n=14) had TSH levels above 2.5 uIU/L. For second trimester, 90.2% (n=184) had TSH levels within the reference limits (0.65-3.83 uIU/mL and 0.4-2.36 MoM) and 8.15% (n=15) had TSH levels over 3 uIU/L. In the third trimester, 90.7% (n=127) women’s TSH levels were within reference limits (0.62-3.78 uIU/mL and 0.39-2.35 MoM) and 3.15% (n=4) had TSH levels over 3 uIU/L.Conclusion:Accurate diagnosis and management of thyroid disease for pregnant women is crucial for maternal-fetal outcomes. Established reference ranges for three trimesters in this study were all higher than the recommended fixed ranges of 2011 American Thyroid Association guideline. http://namikkemalmedj.com/archives/archive-detail/article-preview/trimester-specific-reference-ranges-for-thyroid-ho/52977 electrochemiluminescencepregnancymultiples of medianthyroid hormonetrimester |
| spellingShingle | Arzu Bilge TEKİN Murat YASSA Güldeniz TOKLUCU Derya ERTEN Doğuş BUDAK Bilge DOĞAN TAYMUR Mehmet Akif SARGIN Niyazi TUĞ Trimester Specific Reference Ranges for Thyroid Hormones in Pregnancy with Multiples of Median Values Namık Kemal Tıp Dergisi electrochemiluminescence pregnancy multiples of median thyroid hormone trimester |
| title | Trimester Specific Reference Ranges for Thyroid Hormones in Pregnancy with Multiples of Median Values |
| title_full | Trimester Specific Reference Ranges for Thyroid Hormones in Pregnancy with Multiples of Median Values |
| title_fullStr | Trimester Specific Reference Ranges for Thyroid Hormones in Pregnancy with Multiples of Median Values |
| title_full_unstemmed | Trimester Specific Reference Ranges for Thyroid Hormones in Pregnancy with Multiples of Median Values |
| title_short | Trimester Specific Reference Ranges for Thyroid Hormones in Pregnancy with Multiples of Median Values |
| title_sort | trimester specific reference ranges for thyroid hormones in pregnancy with multiples of median values |
| topic | electrochemiluminescence pregnancy multiples of median thyroid hormone trimester |
| url |
http://namikkemalmedj.com/archives/archive-detail/article-preview/trimester-specific-reference-ranges-for-thyroid-ho/52977
|
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