Peculiarities of bronchial asthma management in children with allelic GSTT1, GSTM1 gene polymorphism
Content of peculiarities of basic anti-inflammatory therapy and its efficacy in children with available or absent deletion polymorphism of GSTM1 and GSTT1 genes coding II phase enzymes of GSTM1 and GSTT1 xenobiotic detoxication considering their acetylation status. It is established that in patient...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Kazimierz Wielki University
2018-01-01
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| Series: | Journal of Education, Health and Sport |
| Subjects: | |
| Online Access: | http://www.ojs.ukw.edu.pl/index.php/johs/article/view/5315 |
| _version_ | 1828860566093955072 |
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| author | O. K. Коloskova T. M. Bilous L. A, Ivanova M. V. Dikal T. G. Kopchuk |
| author_facet | O. K. Коloskova T. M. Bilous L. A, Ivanova M. V. Dikal T. G. Kopchuk |
| author_sort | O. K. Коloskova |
| collection | DOAJ |
| description | Content of peculiarities of basic anti-inflammatory therapy and its efficacy in children with available or absent deletion polymorphism of GSTM1 and GSTT1 genes coding II phase enzymes of GSTM1 and GSTT1 xenobiotic detoxication considering their acetylation status. It is established that in patients of a school age suffering from bronchial asthma with available deletion polymorphism of GSTT1 and GSTМ1 genes associated with slow acetylation phenotype anti-inflammatory therapy should be intensified emphasizing on much higher “step” or by means of addition of other anti-inflammatory drugs. In patients without deletion polymorphism of the examined genes in terms of quick acetylation phenotype average daily doses of iGCS have a tendency to prevailing over the similar ones in patients from the groups of comparison, and their triple administration is reliably higher |
| first_indexed | 2024-12-13T02:41:20Z |
| format | Article |
| id | doaj.art-1990075590784ef28a4473b8d9244e7b |
| institution | Directory Open Access Journal |
| issn | 2391-8306 |
| language | English |
| last_indexed | 2024-12-13T02:41:20Z |
| publishDate | 2018-01-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj.art-1990075590784ef28a4473b8d9244e7b2022-12-22T00:02:16ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062018-01-018119820510.5281/zenodo.11853974943Peculiarities of bronchial asthma management in children with allelic GSTT1, GSTM1 gene polymorphismO. K. Коloskova0T. M. Bilous1L. A, Ivanova2M. V. Dikal3T. G. Kopchuk4Higher State Educational Establishment of Ukraine “Bukovinian State Medical University”, ChernivtsiHigher State Educational Establishment of Ukraine “Bukovinian State Medical University”, ChernivtsiHigher State Educational Establishment of Ukraine “Bukovinian State Medical University”, ChernivtsiHigher State Educational Establishment of Ukraine “Bukovinian State Medical University”, ChernivtsiHigher State Educational Establishment of Ukraine “Bukovinian State Medical University”, ChernivtsiContent of peculiarities of basic anti-inflammatory therapy and its efficacy in children with available or absent deletion polymorphism of GSTM1 and GSTT1 genes coding II phase enzymes of GSTM1 and GSTT1 xenobiotic detoxication considering their acetylation status. It is established that in patients of a school age suffering from bronchial asthma with available deletion polymorphism of GSTT1 and GSTМ1 genes associated with slow acetylation phenotype anti-inflammatory therapy should be intensified emphasizing on much higher “step” or by means of addition of other anti-inflammatory drugs. In patients without deletion polymorphism of the examined genes in terms of quick acetylation phenotype average daily doses of iGCS have a tendency to prevailing over the similar ones in patients from the groups of comparison, and their triple administration is reliably higherhttp://www.ojs.ukw.edu.pl/index.php/johs/article/view/5315bronchial asthma, gstt1, gstм1, gene polymorphism |
| spellingShingle | O. K. Коloskova T. M. Bilous L. A, Ivanova M. V. Dikal T. G. Kopchuk Peculiarities of bronchial asthma management in children with allelic GSTT1, GSTM1 gene polymorphism Journal of Education, Health and Sport bronchial asthma, gstt1, gstм1, gene polymorphism |
| title | Peculiarities of bronchial asthma management in children with allelic GSTT1, GSTM1 gene polymorphism |
| title_full | Peculiarities of bronchial asthma management in children with allelic GSTT1, GSTM1 gene polymorphism |
| title_fullStr | Peculiarities of bronchial asthma management in children with allelic GSTT1, GSTM1 gene polymorphism |
| title_full_unstemmed | Peculiarities of bronchial asthma management in children with allelic GSTT1, GSTM1 gene polymorphism |
| title_short | Peculiarities of bronchial asthma management in children with allelic GSTT1, GSTM1 gene polymorphism |
| title_sort | peculiarities of bronchial asthma management in children with allelic gstt1 gstm1 gene polymorphism |
| topic | bronchial asthma, gstt1, gstм1, gene polymorphism |
| url | http://www.ojs.ukw.edu.pl/index.php/johs/article/view/5315 |
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