Structural characterization of human de novo protein NCYM and its complex with a newly identified DNA aptamer using atomic force microscopy and small-angle X-ray scattering

Structural characterization of human de novo protein NCYM and its complex with a newly identified DNA aptamer using atomic force microscopy and small-angle X-ray scattering

NCYM, a Homininae-specific oncoprotein, is the first de novo gene product experimentally shown to have oncogenic functions. NCYM stabilizes MYCN and β-catenin via direct binding and inhibition of GSK3β and promotes cancer progression in various tumors. Thus, the identification of compounds that bind...

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Bibliographic Details
Main Authors: Seigi Yamamoto, Fumiaki Kono, Kazuma Nakatani, Miwako Hirose, Katsunori Horii, Yoshitaka Hippo, Taro Tamada, Yusuke Suenaga, Tatsuhito Matsuo
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Oncology
Subjects:
de novo protein
NCYM
DNA aptamer
solution structure
AFM
SAXS
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1213678/full

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