Role of Pro-BNP in predicting outcome in acute heart failure patient presenting to a medical emergency: An observational study from North India
Background: Acute heart failure (AHF) is a clinical syndrome defined as the new onset or acutely decompensated heart failure (ADHF) leading to signs and symptoms of heart failure (HF). The critical cut-off values for these biomarkers that suggest high mortality are not clearly defined in previous st...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Journal of Family Medicine and Primary Care |
| Subjects: | |
| Online Access: | http://www.jfmpc.com/article.asp?issn=2249-4863;year=2023;volume=12;issue=12;spage=3156;epage=3159;aulast=Singhal |
| _version_ | 1797232644864344064 |
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| author | Arjun K Singhal Gaurav Singh S K Singh Busi Karunanand Sonu Agrawal |
| author_facet | Arjun K Singhal Gaurav Singh S K Singh Busi Karunanand Sonu Agrawal |
| author_sort | Arjun K Singhal |
| collection | DOAJ |
| description | Background: Acute heart failure (AHF) is a clinical syndrome defined as the new onset or acutely decompensated heart failure (ADHF) leading to signs and symptoms of heart failure (HF). The critical cut-off values for these biomarkers that suggest high mortality are not clearly defined in previous studies. More studies are required to better understand the correlation of Pro- BNP and its association with HF. The primary objective is to study the role of Pro-BNP and critical factors in predicting outcomes in AHF patients presenting to a medical emergency. Materials and Methods: The data from the patients presented with symptoms of HF in the Department of Medical Emergency at our hospital were recorded and analysed. AHF is a clinical syndrome defined as the new onset or ADHF leading to signs and symptoms of HF, as based on the European Society of Cardiology. Results: The present study highlights the various risk factors of AHF in patients and their association with mortality. In the present study, mortality in patients with very high Pro-BNP levels ≥2000 pg/ml was significantly higher than in patients with moderately elevated Pro-BNP. The patients who survived after 5 days of hospitalization had Pro-BNP levels ≤2000 pg/ml, suggesting that very high Pro-BNP levels ≥2000 pg/ml are associated with fatal outcomes. Conclusion: To conclude, diabetes and sepsis are critical factors for the hospitalization and mortality of patients with AHF in northern India. Very high Pro-BNP levels ≥2000 pg/ml in patients with AHF requiring hospitalization and associated with fatal outcomes. |
| first_indexed | 2024-04-24T16:03:33Z |
| format | Article |
| id | doaj.art-199519b17b824586811fdb67cfca180a |
| institution | Directory Open Access Journal |
| issn | 2249-4863 |
| language | English |
| last_indexed | 2024-04-24T16:03:33Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Family Medicine and Primary Care |
| spelling | doaj.art-199519b17b824586811fdb67cfca180a2024-04-01T06:00:31ZengWolters Kluwer Medknow PublicationsJournal of Family Medicine and Primary Care2249-48632023-01-0112123156315910.4103/jfmpc.jfmpc_853_23Role of Pro-BNP in predicting outcome in acute heart failure patient presenting to a medical emergency: An observational study from North IndiaArjun K SinghalGaurav SinghS K SinghBusi KarunanandSonu AgrawalBackground: Acute heart failure (AHF) is a clinical syndrome defined as the new onset or acutely decompensated heart failure (ADHF) leading to signs and symptoms of heart failure (HF). The critical cut-off values for these biomarkers that suggest high mortality are not clearly defined in previous studies. More studies are required to better understand the correlation of Pro- BNP and its association with HF. The primary objective is to study the role of Pro-BNP and critical factors in predicting outcomes in AHF patients presenting to a medical emergency. Materials and Methods: The data from the patients presented with symptoms of HF in the Department of Medical Emergency at our hospital were recorded and analysed. AHF is a clinical syndrome defined as the new onset or ADHF leading to signs and symptoms of HF, as based on the European Society of Cardiology. Results: The present study highlights the various risk factors of AHF in patients and their association with mortality. In the present study, mortality in patients with very high Pro-BNP levels ≥2000 pg/ml was significantly higher than in patients with moderately elevated Pro-BNP. The patients who survived after 5 days of hospitalization had Pro-BNP levels ≤2000 pg/ml, suggesting that very high Pro-BNP levels ≥2000 pg/ml are associated with fatal outcomes. Conclusion: To conclude, diabetes and sepsis are critical factors for the hospitalization and mortality of patients with AHF in northern India. Very high Pro-BNP levels ≥2000 pg/ml in patients with AHF requiring hospitalization and associated with fatal outcomes.http://www.jfmpc.com/article.asp?issn=2249-4863;year=2023;volume=12;issue=12;spage=3156;epage=3159;aulast=Singhalbiomarkeremergency departmentheart failurepatientspro-bnp |
| spellingShingle | Arjun K Singhal Gaurav Singh S K Singh Busi Karunanand Sonu Agrawal Role of Pro-BNP in predicting outcome in acute heart failure patient presenting to a medical emergency: An observational study from North India Journal of Family Medicine and Primary Care biomarker emergency department heart failure patients pro-bnp |
| title | Role of Pro-BNP in predicting outcome in acute heart failure patient presenting to a medical emergency: An observational study from North India |
| title_full | Role of Pro-BNP in predicting outcome in acute heart failure patient presenting to a medical emergency: An observational study from North India |
| title_fullStr | Role of Pro-BNP in predicting outcome in acute heart failure patient presenting to a medical emergency: An observational study from North India |
| title_full_unstemmed | Role of Pro-BNP in predicting outcome in acute heart failure patient presenting to a medical emergency: An observational study from North India |
| title_short | Role of Pro-BNP in predicting outcome in acute heart failure patient presenting to a medical emergency: An observational study from North India |
| title_sort | role of pro bnp in predicting outcome in acute heart failure patient presenting to a medical emergency an observational study from north india |
| topic | biomarker emergency department heart failure patients pro-bnp |
| url | http://www.jfmpc.com/article.asp?issn=2249-4863;year=2023;volume=12;issue=12;spage=3156;epage=3159;aulast=Singhal |
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