Role of Pro-BNP in predicting outcome in acute heart failure patient presenting to a medical emergency: An observational study from North India
Background: Acute heart failure (AHF) is a clinical syndrome defined as the new onset or acutely decompensated heart failure (ADHF) leading to signs and symptoms of heart failure (HF). The critical cut-off values for these biomarkers that suggest high mortality are not clearly defined in previous st...
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Format: | Article |
Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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Series: | Journal of Family Medicine and Primary Care |
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Online Access: | http://www.jfmpc.com/article.asp?issn=2249-4863;year=2023;volume=12;issue=12;spage=3156;epage=3159;aulast=Singhal |
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author | Arjun K Singhal Gaurav Singh S K Singh Busi Karunanand Sonu Agrawal |
author_facet | Arjun K Singhal Gaurav Singh S K Singh Busi Karunanand Sonu Agrawal |
author_sort | Arjun K Singhal |
collection | DOAJ |
description | Background: Acute heart failure (AHF) is a clinical syndrome defined as the new onset or acutely decompensated heart failure (ADHF) leading to signs and symptoms of heart failure (HF). The critical cut-off values for these biomarkers that suggest high mortality are not clearly defined in previous studies. More studies are required to better understand the correlation of Pro- BNP and its association with HF. The primary objective is to study the role of Pro-BNP and critical factors in predicting outcomes in AHF patients presenting to a medical emergency. Materials and Methods: The data from the patients presented with symptoms of HF in the Department of Medical Emergency at our hospital were recorded and analysed. AHF is a clinical syndrome defined as the new onset or ADHF leading to signs and symptoms of HF, as based on the European Society of Cardiology. Results: The present study highlights the various risk factors of AHF in patients and their association with mortality. In the present study, mortality in patients with very high Pro-BNP levels ≥2000 pg/ml was significantly higher than in patients with moderately elevated Pro-BNP. The patients who survived after 5 days of hospitalization had Pro-BNP levels ≤2000 pg/ml, suggesting that very high Pro-BNP levels ≥2000 pg/ml are associated with fatal outcomes. Conclusion: To conclude, diabetes and sepsis are critical factors for the hospitalization and mortality of patients with AHF in northern India. Very high Pro-BNP levels ≥2000 pg/ml in patients with AHF requiring hospitalization and associated with fatal outcomes. |
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institution | Directory Open Access Journal |
issn | 2249-4863 |
language | English |
last_indexed | 2024-04-24T16:03:33Z |
publishDate | 2023-01-01 |
publisher | Wolters Kluwer Medknow Publications |
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series | Journal of Family Medicine and Primary Care |
spelling | doaj.art-199519b17b824586811fdb67cfca180a2024-04-01T06:00:31ZengWolters Kluwer Medknow PublicationsJournal of Family Medicine and Primary Care2249-48632023-01-0112123156315910.4103/jfmpc.jfmpc_853_23Role of Pro-BNP in predicting outcome in acute heart failure patient presenting to a medical emergency: An observational study from North IndiaArjun K SinghalGaurav SinghS K SinghBusi KarunanandSonu AgrawalBackground: Acute heart failure (AHF) is a clinical syndrome defined as the new onset or acutely decompensated heart failure (ADHF) leading to signs and symptoms of heart failure (HF). The critical cut-off values for these biomarkers that suggest high mortality are not clearly defined in previous studies. More studies are required to better understand the correlation of Pro- BNP and its association with HF. The primary objective is to study the role of Pro-BNP and critical factors in predicting outcomes in AHF patients presenting to a medical emergency. Materials and Methods: The data from the patients presented with symptoms of HF in the Department of Medical Emergency at our hospital were recorded and analysed. AHF is a clinical syndrome defined as the new onset or ADHF leading to signs and symptoms of HF, as based on the European Society of Cardiology. Results: The present study highlights the various risk factors of AHF in patients and their association with mortality. In the present study, mortality in patients with very high Pro-BNP levels ≥2000 pg/ml was significantly higher than in patients with moderately elevated Pro-BNP. The patients who survived after 5 days of hospitalization had Pro-BNP levels ≤2000 pg/ml, suggesting that very high Pro-BNP levels ≥2000 pg/ml are associated with fatal outcomes. Conclusion: To conclude, diabetes and sepsis are critical factors for the hospitalization and mortality of patients with AHF in northern India. Very high Pro-BNP levels ≥2000 pg/ml in patients with AHF requiring hospitalization and associated with fatal outcomes.http://www.jfmpc.com/article.asp?issn=2249-4863;year=2023;volume=12;issue=12;spage=3156;epage=3159;aulast=Singhalbiomarkeremergency departmentheart failurepatientspro-bnp |
spellingShingle | Arjun K Singhal Gaurav Singh S K Singh Busi Karunanand Sonu Agrawal Role of Pro-BNP in predicting outcome in acute heart failure patient presenting to a medical emergency: An observational study from North India Journal of Family Medicine and Primary Care biomarker emergency department heart failure patients pro-bnp |
title | Role of Pro-BNP in predicting outcome in acute heart failure patient presenting to a medical emergency: An observational study from North India |
title_full | Role of Pro-BNP in predicting outcome in acute heart failure patient presenting to a medical emergency: An observational study from North India |
title_fullStr | Role of Pro-BNP in predicting outcome in acute heart failure patient presenting to a medical emergency: An observational study from North India |
title_full_unstemmed | Role of Pro-BNP in predicting outcome in acute heart failure patient presenting to a medical emergency: An observational study from North India |
title_short | Role of Pro-BNP in predicting outcome in acute heart failure patient presenting to a medical emergency: An observational study from North India |
title_sort | role of pro bnp in predicting outcome in acute heart failure patient presenting to a medical emergency an observational study from north india |
topic | biomarker emergency department heart failure patients pro-bnp |
url | http://www.jfmpc.com/article.asp?issn=2249-4863;year=2023;volume=12;issue=12;spage=3156;epage=3159;aulast=Singhal |
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