Merkel Cell Polyomavirus Large T Antigen Induces Cellular Senescence for Host Growth Arrest and Viral Genome Persistence through Its Unique Domain

Merkel Cell Polyomavirus Large T Antigen Induces Cellular Senescence for Host Growth Arrest and Viral Genome Persistence through Its Unique Domain

Senescent cells accumulate in the host during the aging process and are associated with age-related pathogeneses, including cancer. Although persistent senescence seems to contribute to many aspects of cellular pathways and homeostasis, the role of senescence in virus-induced human cancer is not wel...

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Bibliographic Details
Main Authors: Alexander M. Pham, Luz E. Ortiz, Aron E. Lukacher, Hyun Jin Kwun
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Cells
Subjects:
senescence
nucleolar stress response
Merkel cell polyomavirus
large T
p53
p21WAF1
Online Access:https://www.mdpi.com/2073-4409/12/3/380

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