Upregulation of Calcium Homeostasis Modulators in Contractile-To-Proliferative Phenotypical Transition of Pulmonary Arterial Smooth Muscle Cells

Upregulation of Calcium Homeostasis Modulators in Contractile-To-Proliferative Phenotypical Transition of Pulmonary Arterial Smooth Muscle Cells

Excessive pulmonary artery (PA) smooth muscle cell (PASMC) proliferation and migration are implicated in the development of pathogenic pulmonary vascular remodeling characterized by concentric arterial wall thickening and arteriole muscularization in patients with pulmonary arterial hypertension (PA...

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Main Authors: Marisela Rodriguez, Jiyuan Chen, Pritesh P. Jain, Aleksandra Babicheva, Mingmei Xiong, Jifeng Li, Ning Lai, Tengteng Zhao, Moises Hernandez, Angela Balistrieri, Sophia Parmisano, Tatum Simonson, Ellen Breen, Daniela Valdez-Jasso, Patricia A. Thistlethwaite, John Y. -J. Shyy, Jian Wang, Joe G. N. Garcia, Ayako Makino, Jason X. -J. Yuan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Physiology
Subjects:
smooth muscle cell
pulmonary hypertension
CALHM channels
contractile-to-proliferative
phenotypical transition
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.714785/full

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