Placental surface area mediates the association between FGFR2 methylation in placenta and full-term low birth weight in girls
Abstract Background Fibroblast growth factor receptor 2 (FGFR2) gene encodes a protein of the fibroblast growth factor receptor family. FGFR2 gene expression is associated with the regulation of implantation process of placenta which plays a vital role in fetal growth. DNA methylation is widely know...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-03-01
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| Series: | Clinical Epigenetics |
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| Online Access: | http://link.springer.com/article/10.1186/s13148-018-0472-5 |
| _version_ | 1818912372293632000 |
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| author | Fu-Ying Tian Xi-Meng Wang Chuanbo Xie Bo Zhao Zhongzheng Niu Lijun Fan Marie-France Hivert Wei-Qing Chen |
| author_facet | Fu-Ying Tian Xi-Meng Wang Chuanbo Xie Bo Zhao Zhongzheng Niu Lijun Fan Marie-France Hivert Wei-Qing Chen |
| author_sort | Fu-Ying Tian |
| collection | DOAJ |
| description | Abstract Background Fibroblast growth factor receptor 2 (FGFR2) gene encodes a protein of the fibroblast growth factor receptor family. FGFR2 gene expression is associated with the regulation of implantation process of placenta which plays a vital role in fetal growth. DNA methylation is widely known as a mechanism of fetal growth. However, it is unclear whether and how DNA methylation of FGFR2 gene in the placenta is associated with full-term low birth weight. This case-control study aims to explore the links between FGFR2 methylation in placenta and full-term low birth weight and to further examine the mediation effect of placental surface area on this association. Results We conducted analyses for each of the five valid CpG sites at FGFR2 in 165 mother-baby pairs (86 FT-LBW vs. 79 FT-NBW) and found that per one standard deviation increase in the DNA methylation of CpG 11 at FGFR2 was associated with 1.64-fold higher risk of full-term low birth weight (OR = 1.64, 95% CI = [1.07, 2.52]) and 0.18 standard deviation decrease in placental surface area (β = − 0.18; standard error = 0.08, p = 0.02). The mediation effect of placental surface area on the association between DNA methylation and full-term low birth weight was significant in girls (OR = 1.38, 95% CI = [1.05, 1.80]) but not in boys. The estimated mediation proportion was 48.38%. Conclusion Our findings suggested that placental surface area mediated the association between DNA methylation of FGFR2 in placenta and full-term low birth weight in a sex-specific manner. Our study supported the importance of placental epigenetic changes in placental development and fetal growth. |
| first_indexed | 2024-12-19T23:13:33Z |
| format | Article |
| id | doaj.art-1995f743339145e894060348f1c079a7 |
| institution | Directory Open Access Journal |
| issn | 1868-7075 1868-7083 |
| language | English |
| last_indexed | 2024-12-19T23:13:33Z |
| publishDate | 2018-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Clinical Epigenetics |
| spelling | doaj.art-1995f743339145e894060348f1c079a72022-12-21T20:02:09ZengBMCClinical Epigenetics1868-70751868-70832018-03-0110111110.1186/s13148-018-0472-5Placental surface area mediates the association between FGFR2 methylation in placenta and full-term low birth weight in girlsFu-Ying Tian0Xi-Meng Wang1Chuanbo Xie2Bo Zhao3Zhongzheng Niu4Lijun Fan5Marie-France Hivert6Wei-Qing Chen7Department of Medical Statistics and Epidemiology, Guangzhou Key Laboratory of Environmental Pollution and Health Assessment, Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen UniversityDepartment of Medical Statistics and Epidemiology, Guangzhou Key Laboratory of Environmental Pollution and Health Assessment, Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen UniversityDepartment of Cancer Prevention Research, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer CenterChildren’s Hospital Boston and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical SchoolDepartment of Epidemiology and Environmental Health, School of Public Health and Health Professions, State University of New York at BuffaloDepartment of Medical Statistics and Epidemiology, Guangzhou Key Laboratory of Environmental Pollution and Health Assessment, Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen UniversityDepartment of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care InstituteDepartment of Medical Statistics and Epidemiology, Guangzhou Key Laboratory of Environmental Pollution and Health Assessment, Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen UniversityAbstract Background Fibroblast growth factor receptor 2 (FGFR2) gene encodes a protein of the fibroblast growth factor receptor family. FGFR2 gene expression is associated with the regulation of implantation process of placenta which plays a vital role in fetal growth. DNA methylation is widely known as a mechanism of fetal growth. However, it is unclear whether and how DNA methylation of FGFR2 gene in the placenta is associated with full-term low birth weight. This case-control study aims to explore the links between FGFR2 methylation in placenta and full-term low birth weight and to further examine the mediation effect of placental surface area on this association. Results We conducted analyses for each of the five valid CpG sites at FGFR2 in 165 mother-baby pairs (86 FT-LBW vs. 79 FT-NBW) and found that per one standard deviation increase in the DNA methylation of CpG 11 at FGFR2 was associated with 1.64-fold higher risk of full-term low birth weight (OR = 1.64, 95% CI = [1.07, 2.52]) and 0.18 standard deviation decrease in placental surface area (β = − 0.18; standard error = 0.08, p = 0.02). The mediation effect of placental surface area on the association between DNA methylation and full-term low birth weight was significant in girls (OR = 1.38, 95% CI = [1.05, 1.80]) but not in boys. The estimated mediation proportion was 48.38%. Conclusion Our findings suggested that placental surface area mediated the association between DNA methylation of FGFR2 in placenta and full-term low birth weight in a sex-specific manner. Our study supported the importance of placental epigenetic changes in placental development and fetal growth.http://link.springer.com/article/10.1186/s13148-018-0472-5FGFR2DNA methylationPlacental surface areaLow birth weightMediation effect |
| spellingShingle | Fu-Ying Tian Xi-Meng Wang Chuanbo Xie Bo Zhao Zhongzheng Niu Lijun Fan Marie-France Hivert Wei-Qing Chen Placental surface area mediates the association between FGFR2 methylation in placenta and full-term low birth weight in girls Clinical Epigenetics FGFR2 DNA methylation Placental surface area Low birth weight Mediation effect |
| title | Placental surface area mediates the association between FGFR2 methylation in placenta and full-term low birth weight in girls |
| title_full | Placental surface area mediates the association between FGFR2 methylation in placenta and full-term low birth weight in girls |
| title_fullStr | Placental surface area mediates the association between FGFR2 methylation in placenta and full-term low birth weight in girls |
| title_full_unstemmed | Placental surface area mediates the association between FGFR2 methylation in placenta and full-term low birth weight in girls |
| title_short | Placental surface area mediates the association between FGFR2 methylation in placenta and full-term low birth weight in girls |
| title_sort | placental surface area mediates the association between fgfr2 methylation in placenta and full term low birth weight in girls |
| topic | FGFR2 DNA methylation Placental surface area Low birth weight Mediation effect |
| url | http://link.springer.com/article/10.1186/s13148-018-0472-5 |
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