The association between frailty and osteoarthritis based on the NHANES and Mendelian randomization study
Introduction The aim of the study was to examine the association between frailty and osteoarthritis. Material and methods We conducted a cross-sectional study in the National Health and Nutrition Examination Survey, while logistic regression was used to explore the association of the two. Mendelian...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Termedia Publishing House
2023-08-01
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| Series: | Archives of Medical Science |
| Subjects: | |
| Online Access: | https://www.archivesofmedicalscience.com/The-association-between-frailty-and-osteoarthritis-based-on-the-NHANES-and-Mendelian,171270,0,2.html |
| Summary: | Introduction
The aim of the study was to examine the association between frailty and osteoarthritis.
Material and methods
We conducted a cross-sectional study in the National Health and Nutrition Examination Survey, while logistic regression was used to explore the association of the two. Mendelian randomization (MR) study was used to explore the causal relationship between the two.
Results
In the cross-sectional study, logistic regression analysis showed that odds ratio (OR) (95% CI) value was 1.07 (1.05, 1.08). In the MR study, the inverse-variance weighting (IVW) results showed OR (95% CI) value of 1.69 (1.01–2.83).
Conclusions
There is both a correlation and a causal relationship between frailty and osteoarthritis, and frailty may be a potentially better response than age to osteoarthritis. |
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| ISSN: | 1734-1922 1896-9151 |