The association between frailty and osteoarthritis based on the NHANES and Mendelian randomization study
Introduction The aim of the study was to examine the association between frailty and osteoarthritis. Material and methods We conducted a cross-sectional study in the National Health and Nutrition Examination Survey, while logistic regression was used to explore the association of the two. Mendelian...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Termedia Publishing House
2023-08-01
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| Series: | Archives of Medical Science |
| Subjects: | |
| Online Access: | https://www.archivesofmedicalscience.com/The-association-between-frailty-and-osteoarthritis-based-on-the-NHANES-and-Mendelian,171270,0,2.html |
| _version_ | 1797435436848644096 |
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| author | Guoxin Huang Da Qian Ying Liu Gaojing Qu Yuanyuan Qian Bin Pei |
| author_facet | Guoxin Huang Da Qian Ying Liu Gaojing Qu Yuanyuan Qian Bin Pei |
| author_sort | Guoxin Huang |
| collection | DOAJ |
| description | Introduction
The aim of the study was to examine the association between frailty and osteoarthritis.
Material and methods
We conducted a cross-sectional study in the National Health and Nutrition Examination Survey, while logistic regression was used to explore the association of the two. Mendelian randomization (MR) study was used to explore the causal relationship between the two.
Results
In the cross-sectional study, logistic regression analysis showed that odds ratio (OR) (95% CI) value was 1.07 (1.05, 1.08). In the MR study, the inverse-variance weighting (IVW) results showed OR (95% CI) value of 1.69 (1.01–2.83).
Conclusions
There is both a correlation and a causal relationship between frailty and osteoarthritis, and frailty may be a potentially better response than age to osteoarthritis. |
| first_indexed | 2024-03-09T10:48:05Z |
| format | Article |
| id | doaj.art-1997cbd64ed341e6b7ac850f75b9d0d1 |
| institution | Directory Open Access Journal |
| issn | 1734-1922 1896-9151 |
| language | English |
| last_indexed | 2024-03-09T10:48:05Z |
| publishDate | 2023-08-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Archives of Medical Science |
| spelling | doaj.art-1997cbd64ed341e6b7ac850f75b9d0d12023-12-01T09:49:08ZengTermedia Publishing HouseArchives of Medical Science1734-19221896-91512023-08-011951545155010.5114/aoms/171270171270The association between frailty and osteoarthritis based on the NHANES and Mendelian randomization studyGuoxin Huang0Da Qian1Ying Liu2Gaojing Qu3Yuanyuan Qian4Bin Pei5Department of Evidence-Based Medicine Center, Xiangyang No.1 People’s Hospital, Hubei University of Medicine, Xiangyang, ChinaDepartment of Burn and Plastic Surgery-Hand Surgery, Changshu Hospital Affiliated to Soochow University, Changshu No.1 People’s Hospital, Changshu, ChinaDepartment of Evidence-Based Medicine Center, Xiangyang No.1 People’s Hospital, Hubei University of Medicine, Xiangyang, ChinaDepartment of Evidence-Based Medicine Center, Xiangyang No.1 People’s Hospital, Hubei University of Medicine, Xiangyang, ChinaDepartment of Burn and Plastic Surgery-Hand Surgery, Changshu Hospital Affiliated to Soochow University, Changshu No.1 People’s Hospital, Changshu, ChinaDepartment of Evidence-Based Medicine Center, Xiangyang No.1 People’s Hospital, Hubei University of Medicine, Xiangyang, ChinaIntroduction The aim of the study was to examine the association between frailty and osteoarthritis. Material and methods We conducted a cross-sectional study in the National Health and Nutrition Examination Survey, while logistic regression was used to explore the association of the two. Mendelian randomization (MR) study was used to explore the causal relationship between the two. Results In the cross-sectional study, logistic regression analysis showed that odds ratio (OR) (95% CI) value was 1.07 (1.05, 1.08). In the MR study, the inverse-variance weighting (IVW) results showed OR (95% CI) value of 1.69 (1.01–2.83). Conclusions There is both a correlation and a causal relationship between frailty and osteoarthritis, and frailty may be a potentially better response than age to osteoarthritis.https://www.archivesofmedicalscience.com/The-association-between-frailty-and-osteoarthritis-based-on-the-NHANES-and-Mendelian,171270,0,2.htmlfrailtyosteoarthritisnational health and nutrition examination surveymendelian randomization |
| spellingShingle | Guoxin Huang Da Qian Ying Liu Gaojing Qu Yuanyuan Qian Bin Pei The association between frailty and osteoarthritis based on the NHANES and Mendelian randomization study Archives of Medical Science frailty osteoarthritis national health and nutrition examination survey mendelian randomization |
| title | The association between frailty and osteoarthritis based on the NHANES and Mendelian randomization study |
| title_full | The association between frailty and osteoarthritis based on the NHANES and Mendelian randomization study |
| title_fullStr | The association between frailty and osteoarthritis based on the NHANES and Mendelian randomization study |
| title_full_unstemmed | The association between frailty and osteoarthritis based on the NHANES and Mendelian randomization study |
| title_short | The association between frailty and osteoarthritis based on the NHANES and Mendelian randomization study |
| title_sort | association between frailty and osteoarthritis based on the nhanes and mendelian randomization study |
| topic | frailty osteoarthritis national health and nutrition examination survey mendelian randomization |
| url | https://www.archivesofmedicalscience.com/The-association-between-frailty-and-osteoarthritis-based-on-the-NHANES-and-Mendelian,171270,0,2.html |
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