Exploring the epigenetic regulation of telomerase reverse transcriptase (TERT) in human cancer cell lines
Telomerase regulation, including TERT promoter methylation, has been of long‐standing interest to cancer biologists. Rowland et al. have now vastly expanded their ongoing characterization of TERT promoter methylation in cancer cells, analyzing the methylation patterns of 833 cell lines from 23 human...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-10-01
|
| Series: | Molecular Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/1878-0261.12798 |
| _version_ | 1797776357894127616 |
|---|---|
| author | Brittany A. McKelvey Martha A. Zeiger Christopher B. Umbricht |
| author_facet | Brittany A. McKelvey Martha A. Zeiger Christopher B. Umbricht |
| author_sort | Brittany A. McKelvey |
| collection | DOAJ |
| description | Telomerase regulation, including TERT promoter methylation, has been of long‐standing interest to cancer biologists. Rowland et al. have now vastly expanded their ongoing characterization of TERT promoter methylation in cancer cells, analyzing the methylation patterns of 833 cell lines from 23 human cancers. They document a highly conserved pattern of hypomethylation around the proximal promoter, as well as a more heterogeneous region of hypermethylation further upstream, both associated with active TERT expression in cancer cells. They further describe the interplay between activating TERT promoter mutations and allelic methylation and transcription patterns. This valuable dataset represents the most extensive characterization of TERT promoter methylation in cancer cells to date and will help guide the future study of transcriptional regulation of telomerase. Comment on: https://doi.org/10.1002/1878‐0261.12786 |
| first_indexed | 2024-03-12T22:48:47Z |
| format | Article |
| id | doaj.art-1997f0563caf450bb268c7c93f2f7a66 |
| institution | Directory Open Access Journal |
| issn | 1574-7891 1878-0261 |
| language | English |
| last_indexed | 2024-03-12T22:48:47Z |
| publishDate | 2020-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Molecular Oncology |
| spelling | doaj.art-1997f0563caf450bb268c7c93f2f7a662023-07-20T17:20:38ZengWileyMolecular Oncology1574-78911878-02612020-10-0114102355235710.1002/1878-0261.12798Exploring the epigenetic regulation of telomerase reverse transcriptase (TERT) in human cancer cell linesBrittany A. McKelvey0Martha A. Zeiger1Christopher B. Umbricht2Department of Surgery Johns Hopkins University Baltimore MD USASurgical Oncology Program National Cancer Institute National Institutes of Health Bethesda MD USADepartment of Surgery Johns Hopkins University Baltimore MD USATelomerase regulation, including TERT promoter methylation, has been of long‐standing interest to cancer biologists. Rowland et al. have now vastly expanded their ongoing characterization of TERT promoter methylation in cancer cells, analyzing the methylation patterns of 833 cell lines from 23 human cancers. They document a highly conserved pattern of hypomethylation around the proximal promoter, as well as a more heterogeneous region of hypermethylation further upstream, both associated with active TERT expression in cancer cells. They further describe the interplay between activating TERT promoter mutations and allelic methylation and transcription patterns. This valuable dataset represents the most extensive characterization of TERT promoter methylation in cancer cells to date and will help guide the future study of transcriptional regulation of telomerase. Comment on: https://doi.org/10.1002/1878‐0261.12786https://doi.org/10.1002/1878-0261.12798epigenetic regulationmonoallelic gene expressionmonoallelic methylationtelomerase reverse transcriptaseTERT promoter methylationTERT promoter mutation |
| spellingShingle | Brittany A. McKelvey Martha A. Zeiger Christopher B. Umbricht Exploring the epigenetic regulation of telomerase reverse transcriptase (TERT) in human cancer cell lines Molecular Oncology epigenetic regulation monoallelic gene expression monoallelic methylation telomerase reverse transcriptase TERT promoter methylation TERT promoter mutation |
| title | Exploring the epigenetic regulation of telomerase reverse transcriptase (TERT) in human cancer cell lines |
| title_full | Exploring the epigenetic regulation of telomerase reverse transcriptase (TERT) in human cancer cell lines |
| title_fullStr | Exploring the epigenetic regulation of telomerase reverse transcriptase (TERT) in human cancer cell lines |
| title_full_unstemmed | Exploring the epigenetic regulation of telomerase reverse transcriptase (TERT) in human cancer cell lines |
| title_short | Exploring the epigenetic regulation of telomerase reverse transcriptase (TERT) in human cancer cell lines |
| title_sort | exploring the epigenetic regulation of telomerase reverse transcriptase tert in human cancer cell lines |
| topic | epigenetic regulation monoallelic gene expression monoallelic methylation telomerase reverse transcriptase TERT promoter methylation TERT promoter mutation |
| url | https://doi.org/10.1002/1878-0261.12798 |
| work_keys_str_mv | AT brittanyamckelvey exploringtheepigeneticregulationoftelomerasereversetranscriptasetertinhumancancercelllines AT marthaazeiger exploringtheepigeneticregulationoftelomerasereversetranscriptasetertinhumancancercelllines AT christopherbumbricht exploringtheepigeneticregulationoftelomerasereversetranscriptasetertinhumancancercelllines |