Heath-related quality of life in thyroid cancer patients following radioiodine ablation
<p>Abstract</p> <p>Background</p> <p>There is limited information about the medium to long-term health-related quality of life (QOL) in thyroid cancer patients after initial therapy and the existing studies suffer from limitations. The aim of the study was to assess the...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2011-05-01
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| Series: | Health and Quality of Life Outcomes |
| Online Access: | http://www.hqlo.com/content/9/1/33 |
| _version_ | 1828809692009201664 |
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| author | Henry Jean-françois Palazzo Fausto F Auquier Pascal Loundou Anderson De Micco Catherine Fortanier Cécile Sebag Frédéric Baumstarck-Barrau Karine Taïeb David Mundler Olivier |
| author_facet | Henry Jean-françois Palazzo Fausto F Auquier Pascal Loundou Anderson De Micco Catherine Fortanier Cécile Sebag Frédéric Baumstarck-Barrau Karine Taïeb David Mundler Olivier |
| author_sort | Henry Jean-françois |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>There is limited information about the medium to long-term health-related quality of life (QOL) in thyroid cancer patients after initial therapy and the existing studies suffer from limitations. The aim of the study was to assess the determinants of medium-term QOL after the initial therapy.</p> <p>Methods</p> <p>Following a total thyroidectomy, 88 thyroid cancer patients received either rhTSH or hypothyroid-assisted radioiodine ablation (RRA) using 3.7 GBq (100 mCi) of radioiodine. QOL evaluation of the patients using the validated Functional Assessment of Chronic Illness & Therapy (FACIT) was performed at the time of inclusion (t0) and later at the 9-month post-RRA (t1).</p> <p>Results</p> <p>83 patients were eligible for the final evaluation. Medium-term FACIT scores were not statistically different between t0 and t1 patients. All but one domain of the QOL score was similar between t0 and t1. Using a multivariate analysis, only age and immediate postoperative QOL scores were found to be determinants of the overall medium term 9-month QOL scores. Analysis showed that 'high QOL levels' (baseline and 9-month) and 'no depression', 'low anxiety levels', were associated with '<45yrs', 'men', 'partner', and 'rhTSH stimulation'.</p> <p>Conclusions</p> <p>The use of radioiodine ablation does not seem to affect the medium term QOL scores of patients. Medium-term QOL is mainly determined by pre-ablation QOL. The assessment of baseline QOL might be interesting to evaluate in order to adapt the treatment protocols, the preventive strategies, and medical information to patients for potentially improving their outcomes.</p> |
| first_indexed | 2024-12-12T09:00:37Z |
| format | Article |
| id | doaj.art-1998104265114d13b8f5ec0ba5cb16ce |
| institution | Directory Open Access Journal |
| issn | 1477-7525 |
| language | English |
| last_indexed | 2024-12-12T09:00:37Z |
| publishDate | 2011-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Health and Quality of Life Outcomes |
| spelling | doaj.art-1998104265114d13b8f5ec0ba5cb16ce2022-12-22T00:29:51ZengBMCHealth and Quality of Life Outcomes1477-75252011-05-01913310.1186/1477-7525-9-33Heath-related quality of life in thyroid cancer patients following radioiodine ablationHenry Jean-françoisPalazzo Fausto FAuquier PascalLoundou AndersonDe Micco CatherineFortanier CécileSebag FrédéricBaumstarck-Barrau KarineTaïeb DavidMundler Olivier<p>Abstract</p> <p>Background</p> <p>There is limited information about the medium to long-term health-related quality of life (QOL) in thyroid cancer patients after initial therapy and the existing studies suffer from limitations. The aim of the study was to assess the determinants of medium-term QOL after the initial therapy.</p> <p>Methods</p> <p>Following a total thyroidectomy, 88 thyroid cancer patients received either rhTSH or hypothyroid-assisted radioiodine ablation (RRA) using 3.7 GBq (100 mCi) of radioiodine. QOL evaluation of the patients using the validated Functional Assessment of Chronic Illness & Therapy (FACIT) was performed at the time of inclusion (t0) and later at the 9-month post-RRA (t1).</p> <p>Results</p> <p>83 patients were eligible for the final evaluation. Medium-term FACIT scores were not statistically different between t0 and t1 patients. All but one domain of the QOL score was similar between t0 and t1. Using a multivariate analysis, only age and immediate postoperative QOL scores were found to be determinants of the overall medium term 9-month QOL scores. Analysis showed that 'high QOL levels' (baseline and 9-month) and 'no depression', 'low anxiety levels', were associated with '<45yrs', 'men', 'partner', and 'rhTSH stimulation'.</p> <p>Conclusions</p> <p>The use of radioiodine ablation does not seem to affect the medium term QOL scores of patients. Medium-term QOL is mainly determined by pre-ablation QOL. The assessment of baseline QOL might be interesting to evaluate in order to adapt the treatment protocols, the preventive strategies, and medical information to patients for potentially improving their outcomes.</p>http://www.hqlo.com/content/9/1/33 |
| spellingShingle | Henry Jean-françois Palazzo Fausto F Auquier Pascal Loundou Anderson De Micco Catherine Fortanier Cécile Sebag Frédéric Baumstarck-Barrau Karine Taïeb David Mundler Olivier Heath-related quality of life in thyroid cancer patients following radioiodine ablation Health and Quality of Life Outcomes |
| title | Heath-related quality of life in thyroid cancer patients following radioiodine ablation |
| title_full | Heath-related quality of life in thyroid cancer patients following radioiodine ablation |
| title_fullStr | Heath-related quality of life in thyroid cancer patients following radioiodine ablation |
| title_full_unstemmed | Heath-related quality of life in thyroid cancer patients following radioiodine ablation |
| title_short | Heath-related quality of life in thyroid cancer patients following radioiodine ablation |
| title_sort | heath related quality of life in thyroid cancer patients following radioiodine ablation |
| url | http://www.hqlo.com/content/9/1/33 |
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