New findings on the action of hypericin in hypoxic cancer cells with a focus on the modulation of side population cells

New findings on the action of hypericin in hypoxic cancer cells with a focus on the modulation of side population cells

The presence of key hypoxia regulators, namely, hypoxia-inducible factor (HIF)-1α or HIF-2α, in tumors is associated with poor patient prognosis. Hypoxia massively activates several genes, including the one encoding the BCRP transporter that proffers multidrug resistance to cancer cells through the...

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Bibliographic Details
Main Authors: Viktória Buľková, Jana Vargová, Marián Babinčák, Rastislav Jendželovský, Zbyněk Zdráhal, Pavel Roudnický, Ján Košuth, Peter Fedoročko
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Hypericin
Hypoxia
Breast cancer resistance protein
Side population
ECM reorganization
Proteomics
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223006194

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