Utility of N-aryl 2-aroylhydrazono-propanehydrazonoyl chlorides as precursors for synthesis of new functionalized 1,3,4-thiadiazoles with potential antimicrobial activity
Starting from N-aryl 2-aroylhydrazono-propanehydrazonoyl chlorides, a series of new functionalized 1,3,4-thiadiazoles were prepared. The structures of the compounds prepared were confirmed by both elemental and spectral analyses as well as by alternate synthesis. The mechanisms of the studied reacti...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2015-11-01
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| Series: | Journal of Advanced Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2090123214000940 |
| _version_ | 1819038559147917312 |
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| author | Abdou O. Abdelhamid Sobhi M. Gomha Ahmad S. Shawali |
| author_facet | Abdou O. Abdelhamid Sobhi M. Gomha Ahmad S. Shawali |
| author_sort | Abdou O. Abdelhamid |
| collection | DOAJ |
| description | Starting from N-aryl 2-aroylhydrazono-propanehydrazonoyl chlorides, a series of new functionalized 1,3,4-thiadiazoles were prepared. The structures of the compounds prepared were confirmed by both elemental and spectral analyses as well as by alternate synthesis. The mechanisms of the studied reactions are outlined. The antimicrobial activities of the compounds prepared were screened and the results showed that most of such compounds exhibit considerable activities. |
| first_indexed | 2024-12-21T08:39:14Z |
| format | Article |
| id | doaj.art-19994b2a506841cf917073784e70738c |
| institution | Directory Open Access Journal |
| issn | 2090-1232 2090-1224 |
| language | English |
| last_indexed | 2024-12-21T08:39:14Z |
| publishDate | 2015-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Advanced Research |
| spelling | doaj.art-19994b2a506841cf917073784e70738c2022-12-21T19:09:59ZengElsevierJournal of Advanced Research2090-12322090-12242015-11-016688589310.1016/j.jare.2014.08.007Utility of N-aryl 2-aroylhydrazono-propanehydrazonoyl chlorides as precursors for synthesis of new functionalized 1,3,4-thiadiazoles with potential antimicrobial activityAbdou O. AbdelhamidSobhi M. GomhaAhmad S. ShawaliStarting from N-aryl 2-aroylhydrazono-propanehydrazonoyl chlorides, a series of new functionalized 1,3,4-thiadiazoles were prepared. The structures of the compounds prepared were confirmed by both elemental and spectral analyses as well as by alternate synthesis. The mechanisms of the studied reactions are outlined. The antimicrobial activities of the compounds prepared were screened and the results showed that most of such compounds exhibit considerable activities.http://www.sciencedirect.com/science/article/pii/S2090123214000940Hydrazonoyl halidesHeterocycles1,3,4-ThiadiazolesNitriliminesNucleophilic substitution |
| spellingShingle | Abdou O. Abdelhamid Sobhi M. Gomha Ahmad S. Shawali Utility of N-aryl 2-aroylhydrazono-propanehydrazonoyl chlorides as precursors for synthesis of new functionalized 1,3,4-thiadiazoles with potential antimicrobial activity Journal of Advanced Research Hydrazonoyl halides Heterocycles 1,3,4-Thiadiazoles Nitrilimines Nucleophilic substitution |
| title | Utility of N-aryl 2-aroylhydrazono-propanehydrazonoyl chlorides as precursors for synthesis of new functionalized 1,3,4-thiadiazoles with potential antimicrobial activity |
| title_full | Utility of N-aryl 2-aroylhydrazono-propanehydrazonoyl chlorides as precursors for synthesis of new functionalized 1,3,4-thiadiazoles with potential antimicrobial activity |
| title_fullStr | Utility of N-aryl 2-aroylhydrazono-propanehydrazonoyl chlorides as precursors for synthesis of new functionalized 1,3,4-thiadiazoles with potential antimicrobial activity |
| title_full_unstemmed | Utility of N-aryl 2-aroylhydrazono-propanehydrazonoyl chlorides as precursors for synthesis of new functionalized 1,3,4-thiadiazoles with potential antimicrobial activity |
| title_short | Utility of N-aryl 2-aroylhydrazono-propanehydrazonoyl chlorides as precursors for synthesis of new functionalized 1,3,4-thiadiazoles with potential antimicrobial activity |
| title_sort | utility of n aryl 2 aroylhydrazono propanehydrazonoyl chlorides as precursors for synthesis of new functionalized 1 3 4 thiadiazoles with potential antimicrobial activity |
| topic | Hydrazonoyl halides Heterocycles 1,3,4-Thiadiazoles Nitrilimines Nucleophilic substitution |
| url | http://www.sciencedirect.com/science/article/pii/S2090123214000940 |
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