Plasmonic Layer as a Localized Temperature Control Element for Surface Plasmonic Resonance-Based Sensors
Surface plasmon resonance (SPR) sensing is a well-established high-sensitivity, label-free and real-time detection technique for biomolecular interaction study. Its primary working principle consists of the measurement of the optical refractive index of the medium that is in close vicinity of the se...
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MDPI AG
2021-03-01
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Online Access: | https://www.mdpi.com/1424-8220/21/6/2035 |
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author | Sivaramakrishnan Ganesan Sophie Maricot Jean-Francois Robillard Etienne Okada Mohamed-Taieb Bakouche Laurent Hay Jean-Pierre Vilcot |
author_facet | Sivaramakrishnan Ganesan Sophie Maricot Jean-Francois Robillard Etienne Okada Mohamed-Taieb Bakouche Laurent Hay Jean-Pierre Vilcot |
author_sort | Sivaramakrishnan Ganesan |
collection | DOAJ |
description | Surface plasmon resonance (SPR) sensing is a well-established high-sensitivity, label-free and real-time detection technique for biomolecular interaction study. Its primary working principle consists of the measurement of the optical refractive index of the medium that is in close vicinity of the sensor surface. Bio-functionalization techniques allow biomolecular events to be located in such a way. Since optical refractive indices of any medium varies with the temperature, the place where the measurement takes place shall be within a temperature-controlled environment in order to ensure any temperature fluctuation is interpreted as a biomolecular event. Since the SPR measurement probes the sensed medium within the penetration depth of the plasmonic wave, which is less or in the order of 1 µm, we propose to use the metallic film constituting the detection surface as a localized heater aiming at controlling finely and quickly the temperature of the sensed medium. The Joule heating principle is then used and the modeling of the heater is reported as well as its validation by thermal IR imaging. Using water as a demonstration medium, SPR measurement results at different temperatures are successfully compared to the theoretical optical refractive index of water versus temperature. |
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issn | 1424-8220 |
language | English |
last_indexed | 2024-03-10T13:16:09Z |
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spelling | doaj.art-1999d9c0e7bd4b96b0b263adf70f74c42023-11-21T10:22:07ZengMDPI AGSensors1424-82202021-03-01216203510.3390/s21062035Plasmonic Layer as a Localized Temperature Control Element for Surface Plasmonic Resonance-Based SensorsSivaramakrishnan Ganesan0Sophie Maricot1Jean-Francois Robillard2Etienne Okada3Mohamed-Taieb Bakouche4Laurent Hay5Jean-Pierre Vilcot6Univ. Lille, CNRS, Centrale Lille, Univ. Polytechnique Hauts-de-France, Junia, UMR 8520—IEMN, F-59000 Lille, FranceUniv. Lille, CNRS, Centrale Lille, Univ. Polytechnique Hauts-de-France, Junia, UMR 8520—IEMN, F-59000 Lille, FranceUniv. Lille, CNRS, Centrale Lille, Univ. Polytechnique Hauts-de-France, Junia, UMR 8520—IEMN, F-59000 Lille, FranceUniv. Lille, CNRS, Centrale Lille, Univ. Polytechnique Hauts-de-France, Junia, UMR 8520—IEMN, F-59000 Lille, FranceUniv. Lille, CNRS, Centrale Lille, Univ. Polytechnique Hauts-de-France, Junia, UMR 8520—IEMN, F-59000 Lille, FranceUniv. Lille, CNRS, UMR8523-PhLAM-Physique des Lasers Atomes et Molécules, CERLA/IRCICA, F-59000 Lille, FranceUniv. Lille, CNRS, Centrale Lille, Univ. Polytechnique Hauts-de-France, Junia, UMR 8520—IEMN, F-59000 Lille, FranceSurface plasmon resonance (SPR) sensing is a well-established high-sensitivity, label-free and real-time detection technique for biomolecular interaction study. Its primary working principle consists of the measurement of the optical refractive index of the medium that is in close vicinity of the sensor surface. Bio-functionalization techniques allow biomolecular events to be located in such a way. Since optical refractive indices of any medium varies with the temperature, the place where the measurement takes place shall be within a temperature-controlled environment in order to ensure any temperature fluctuation is interpreted as a biomolecular event. Since the SPR measurement probes the sensed medium within the penetration depth of the plasmonic wave, which is less or in the order of 1 µm, we propose to use the metallic film constituting the detection surface as a localized heater aiming at controlling finely and quickly the temperature of the sensed medium. The Joule heating principle is then used and the modeling of the heater is reported as well as its validation by thermal IR imaging. Using water as a demonstration medium, SPR measurement results at different temperatures are successfully compared to the theoretical optical refractive index of water versus temperature.https://www.mdpi.com/1424-8220/21/6/2035surface plasmon resonanceplasmonic sensortemperature controllocalized heating |
spellingShingle | Sivaramakrishnan Ganesan Sophie Maricot Jean-Francois Robillard Etienne Okada Mohamed-Taieb Bakouche Laurent Hay Jean-Pierre Vilcot Plasmonic Layer as a Localized Temperature Control Element for Surface Plasmonic Resonance-Based Sensors Sensors surface plasmon resonance plasmonic sensor temperature control localized heating |
title | Plasmonic Layer as a Localized Temperature Control Element for Surface Plasmonic Resonance-Based Sensors |
title_full | Plasmonic Layer as a Localized Temperature Control Element for Surface Plasmonic Resonance-Based Sensors |
title_fullStr | Plasmonic Layer as a Localized Temperature Control Element for Surface Plasmonic Resonance-Based Sensors |
title_full_unstemmed | Plasmonic Layer as a Localized Temperature Control Element for Surface Plasmonic Resonance-Based Sensors |
title_short | Plasmonic Layer as a Localized Temperature Control Element for Surface Plasmonic Resonance-Based Sensors |
title_sort | plasmonic layer as a localized temperature control element for surface plasmonic resonance based sensors |
topic | surface plasmon resonance plasmonic sensor temperature control localized heating |
url | https://www.mdpi.com/1424-8220/21/6/2035 |
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