Survival benefit of adjuvant radiotherapy in stage III and IV bladder cancer: results of 170 patients
Yasser Bayoumi,1 Tarek Heikal,2 Hossam Darweish2 1Radiation Oncology, National Cancer Institute, Cairo University, Giza, Egypt; 2Medical Oncology, Damietta Cancer Institute, Ministry of Health, Damietta, Egypt Background: Radical cystectomy (RC) with or without neoadjuvant chemotherapy is the stand...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2014-11-01
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| Series: | Cancer Management and Research |
| Online Access: | http://www.dovepress.com/survival-benefit-of-adjuvant-radiotherapy-in-stage-iii-and-iv-bladder--peer-reviewed-article-CMAR |
| _version_ | 1818277269112619008 |
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| author | Bayoumi Y Heikal T Darweish H |
| author_facet | Bayoumi Y Heikal T Darweish H |
| author_sort | Bayoumi Y |
| collection | DOAJ |
| description | Yasser Bayoumi,1 Tarek Heikal,2 Hossam Darweish2 1Radiation Oncology, National Cancer Institute, Cairo University, Giza, Egypt; 2Medical Oncology, Damietta Cancer Institute, Ministry of Health, Damietta, Egypt Background: Radical cystectomy (RC) with or without neoadjuvant chemotherapy is the standard treatment for muscle-invasive bladder cancers. However, the locoregional recurrence rate is still significantly higher for locally advanced cases post-RC. The underuse of postoperative radiotherapy (PORT) in such cases after RC is related mainly to a lack of proven survival benefit. Here we are reporting our long-term Egyptian experience with bladder cancer patients treated with up-front RC with or without conformal PORT. Patients and methods: This retrospective study included 170 locally advanced bladder cancer (T3–T4, N0/N1, M0) patients who had RC performed with or without PORT at Damietta Cancer Institute during the period of 1998–2006. The treatment outcomes and toxicity profile of PORT were evaluated and compared with those of a non-PORT group of patients. Results: Ninety-two patients received PORT; 78 did not. At median follow-up of 47 months (range, 17–77 months), 33% locoregional recurrences were seen in the PORT group versus 55% in the non-PORT group (P<0.001). The overall distant metastasis rate in the whole group was 39%, with no difference between the two groups. The 5-year disease-free survival for the whole group of patients was 53%±11%, which was significantly affected by additional PORT, and 65%±13% compared with 40%±9% for the non-PORT group (P=0.04). The pathological subtypes did not affect 5-year disease-free survival significantly (P=0.9). The 5-year overall survival was 44%±10%. Using multivariate analysis, PORT, stage, and extravesical extension (positive surgical margins) were found to be important prognostic factors for locoregional control. Stage and lymph node status were important prognosticators for distant metastasis control. Conclusion: PORT was found to be a safe and effective tool in decreasing local recurrence rates and improving disease-free survival. Keywords: bladder cancer, postoperative radiotherapy, locoregional recurrence, overall survival |
| first_indexed | 2024-12-12T22:58:51Z |
| format | Article |
| id | doaj.art-199a8860aaec42978dda2795674aa4be |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-12-12T22:58:51Z |
| publishDate | 2014-11-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj.art-199a8860aaec42978dda2795674aa4be2022-12-22T00:08:53ZengDove Medical PressCancer Management and Research1179-13222014-11-012014default45946519316Survival benefit of adjuvant radiotherapy in stage III and IV bladder cancer: results of 170 patientsBayoumi YHeikal TDarweish HYasser Bayoumi,1 Tarek Heikal,2 Hossam Darweish2 1Radiation Oncology, National Cancer Institute, Cairo University, Giza, Egypt; 2Medical Oncology, Damietta Cancer Institute, Ministry of Health, Damietta, Egypt Background: Radical cystectomy (RC) with or without neoadjuvant chemotherapy is the standard treatment for muscle-invasive bladder cancers. However, the locoregional recurrence rate is still significantly higher for locally advanced cases post-RC. The underuse of postoperative radiotherapy (PORT) in such cases after RC is related mainly to a lack of proven survival benefit. Here we are reporting our long-term Egyptian experience with bladder cancer patients treated with up-front RC with or without conformal PORT. Patients and methods: This retrospective study included 170 locally advanced bladder cancer (T3–T4, N0/N1, M0) patients who had RC performed with or without PORT at Damietta Cancer Institute during the period of 1998–2006. The treatment outcomes and toxicity profile of PORT were evaluated and compared with those of a non-PORT group of patients. Results: Ninety-two patients received PORT; 78 did not. At median follow-up of 47 months (range, 17–77 months), 33% locoregional recurrences were seen in the PORT group versus 55% in the non-PORT group (P<0.001). The overall distant metastasis rate in the whole group was 39%, with no difference between the two groups. The 5-year disease-free survival for the whole group of patients was 53%±11%, which was significantly affected by additional PORT, and 65%±13% compared with 40%±9% for the non-PORT group (P=0.04). The pathological subtypes did not affect 5-year disease-free survival significantly (P=0.9). The 5-year overall survival was 44%±10%. Using multivariate analysis, PORT, stage, and extravesical extension (positive surgical margins) were found to be important prognostic factors for locoregional control. Stage and lymph node status were important prognosticators for distant metastasis control. Conclusion: PORT was found to be a safe and effective tool in decreasing local recurrence rates and improving disease-free survival. Keywords: bladder cancer, postoperative radiotherapy, locoregional recurrence, overall survivalhttp://www.dovepress.com/survival-benefit-of-adjuvant-radiotherapy-in-stage-iii-and-iv-bladder--peer-reviewed-article-CMAR |
| spellingShingle | Bayoumi Y Heikal T Darweish H Survival benefit of adjuvant radiotherapy in stage III and IV bladder cancer: results of 170 patients Cancer Management and Research |
| title | Survival benefit of adjuvant radiotherapy in stage III and IV bladder cancer: results of 170 patients |
| title_full | Survival benefit of adjuvant radiotherapy in stage III and IV bladder cancer: results of 170 patients |
| title_fullStr | Survival benefit of adjuvant radiotherapy in stage III and IV bladder cancer: results of 170 patients |
| title_full_unstemmed | Survival benefit of adjuvant radiotherapy in stage III and IV bladder cancer: results of 170 patients |
| title_short | Survival benefit of adjuvant radiotherapy in stage III and IV bladder cancer: results of 170 patients |
| title_sort | survival benefit of adjuvant radiotherapy in stage iii and iv bladder cancer results of 170 patients |
| url | http://www.dovepress.com/survival-benefit-of-adjuvant-radiotherapy-in-stage-iii-and-iv-bladder--peer-reviewed-article-CMAR |
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