Transient targeting of hypothalamic orexin neurons alleviates seizures in a mouse model of epilepsy
Abstract Lateral hypothalamic (LH) hypocretin/orexin neurons (HONs) control brain-wide electrical excitation. Abnormally high excitation produces epileptic seizures, which affect millions of people and need better treatments. HON population activity spikes from minute to minute, but the role of this...
Main Authors: | Han-Tao Li, Paulius Viskaitis, Eva Bracey, Daria Peleg-Raibstein, Denis Burdakov |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2024-02-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-024-45515-5 |
Similar Items
-
Control of hypothalamic orexin neurons by acid and CO2.
by: Williams, R, et al.
Published: (2007) -
Low-voltage-activated A-current controls the firing dynamics of mouse hypothalamic orexin neurons.
by: Burdakov, D, et al.
Published: (2004) -
Metabolism-independent sugar sensing in central orexin neurons.
by: González, J, et al.
Published: (2008) -
Inhibitory interplay between orexin neurons and eating
by: González, JA, et al.
Published: (2016) -
Stimulation of orexin/hypocretin neurones by thyrotropin-releasing hormone.
by: González, J, et al.
Published: (2009)