Rapid Detection and Identification of Overdose Drugs in Saliva by Surface-Enhanced Raman Scattering Using Fused Gold Colloids
The number of drug-related emergency room visits in the United States doubled from 2004 to 2009 to 4.6 million. Consequently there is a critical need to rapidly identify the offending drug(s), so that the appropriate medical care can be administered. In an effort to meet this need we have been inves...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2011-07-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1999-4923/3/3/425/ |
| _version_ | 1811263260457959424 |
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| author | Frank Inscore Hermes Huang Atanu Sengupta Chetan Shende Stuart Farquharson |
| author_facet | Frank Inscore Hermes Huang Atanu Sengupta Chetan Shende Stuart Farquharson |
| author_sort | Frank Inscore |
| collection | DOAJ |
| description | The number of drug-related emergency room visits in the United States doubled from 2004 to 2009 to 4.6 million. Consequently there is a critical need to rapidly identify the offending drug(s), so that the appropriate medical care can be administered. In an effort to meet this need we have been investigating the ability of surface-enhanced Raman spectroscopy (SERS) to detect and identify numerous drugs in saliva at ng/mL concentrations within 10 minutes. Identification is provided by matching measured spectra to a SERS library comprised of over 150 different drugs, each of which possess a unique spectrum. Trace detection is provided by fused gold colloids trapped within a porous glass matrix that generate SERS. Speed is provided by a syringe-driven sample system that uses a solid-phase extraction capillary combined with a SERS-active capillary in series. Spectral collection is provided by a portable Raman analyzer. Here we describe successful measurement of representative illicit, prescribed, and over-the-counter drugs by SERS, and 50 ng/mL cocaine in saliva as part of a focused study. |
| first_indexed | 2024-04-12T19:41:44Z |
| format | Article |
| id | doaj.art-199d7c4016a848b6b9aef93330b2650d |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-04-12T19:41:44Z |
| publishDate | 2011-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-199d7c4016a848b6b9aef93330b2650d2022-12-22T03:19:04ZengMDPI AGPharmaceutics1999-49232011-07-013342543910.3390/pharmaceutics3030425Rapid Detection and Identification of Overdose Drugs in Saliva by Surface-Enhanced Raman Scattering Using Fused Gold ColloidsFrank InscoreHermes HuangAtanu SenguptaChetan ShendeStuart FarquharsonThe number of drug-related emergency room visits in the United States doubled from 2004 to 2009 to 4.6 million. Consequently there is a critical need to rapidly identify the offending drug(s), so that the appropriate medical care can be administered. In an effort to meet this need we have been investigating the ability of surface-enhanced Raman spectroscopy (SERS) to detect and identify numerous drugs in saliva at ng/mL concentrations within 10 minutes. Identification is provided by matching measured spectra to a SERS library comprised of over 150 different drugs, each of which possess a unique spectrum. Trace detection is provided by fused gold colloids trapped within a porous glass matrix that generate SERS. Speed is provided by a syringe-driven sample system that uses a solid-phase extraction capillary combined with a SERS-active capillary in series. Spectral collection is provided by a portable Raman analyzer. Here we describe successful measurement of representative illicit, prescribed, and over-the-counter drugs by SERS, and 50 ng/mL cocaine in saliva as part of a focused study.http://www.mdpi.com/1999-4923/3/3/425/drug analysisillicit drugsdrug overdoseSERSRaman spectroscopyemergency room |
| spellingShingle | Frank Inscore Hermes Huang Atanu Sengupta Chetan Shende Stuart Farquharson Rapid Detection and Identification of Overdose Drugs in Saliva by Surface-Enhanced Raman Scattering Using Fused Gold Colloids Pharmaceutics drug analysis illicit drugs drug overdose SERS Raman spectroscopy emergency room |
| title | Rapid Detection and Identification of Overdose Drugs in Saliva by Surface-Enhanced Raman Scattering Using Fused Gold Colloids |
| title_full | Rapid Detection and Identification of Overdose Drugs in Saliva by Surface-Enhanced Raman Scattering Using Fused Gold Colloids |
| title_fullStr | Rapid Detection and Identification of Overdose Drugs in Saliva by Surface-Enhanced Raman Scattering Using Fused Gold Colloids |
| title_full_unstemmed | Rapid Detection and Identification of Overdose Drugs in Saliva by Surface-Enhanced Raman Scattering Using Fused Gold Colloids |
| title_short | Rapid Detection and Identification of Overdose Drugs in Saliva by Surface-Enhanced Raman Scattering Using Fused Gold Colloids |
| title_sort | rapid detection and identification of overdose drugs in saliva by surface enhanced raman scattering using fused gold colloids |
| topic | drug analysis illicit drugs drug overdose SERS Raman spectroscopy emergency room |
| url | http://www.mdpi.com/1999-4923/3/3/425/ |
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