Takotsubo syndrome: left atrial and ventricular myocardial strain impairment in the subacute and convalescent phases assessed by CMR
Abstract Background We investigated the differences in impairment of left ventricle (LV) and left atrium (LA) contractile dysfunction between subacute and convalescent takotsubo syndrome (TTS), using myocardial strain analysis by cardiac magnetic resonance (CMR) feature-tracking technique. Methods W...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2024-02-01
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| Series: | European Radiology Experimental |
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| Online Access: | https://doi.org/10.1186/s41747-024-00423-7 |
| _version_ | 1827328652105220096 |
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| author | Giacomo Pambianchi Livia Marchitelli Giulia Cundari Letizia Ruoli Luca Conia Carlo Catalano Nicola Galea |
| author_facet | Giacomo Pambianchi Livia Marchitelli Giulia Cundari Letizia Ruoli Luca Conia Carlo Catalano Nicola Galea |
| author_sort | Giacomo Pambianchi |
| collection | DOAJ |
| description | Abstract Background We investigated the differences in impairment of left ventricle (LV) and left atrium (LA) contractile dysfunction between subacute and convalescent takotsubo syndrome (TTS), using myocardial strain analysis by cardiac magnetic resonance (CMR) feature-tracking technique. Methods We retrospectively selected 50 patients with TTS clinical-radiological diagnosis who underwent CMR within 30 days since symptoms onset: 19 studied during the early subacute phase (sTTS, ≤ 7 days) and 31 during the convalescence (cTTS, 8–30 days). We measured the following: LV global longitudinal, circumferential, and radial strain (lvGLS, lvGCS, lvGRS) and strain rate (SR) and LA reservoir (laS_r), conduit (laS_cd), and booster pump strain (laS_bp) and strain rate (laSR_r, laSR_cd, laSR_bp). Patients were compared with 30 age- and sex-matched controls. Results All patients were women (mean age 63 years). TTS patients showed altered LV- and LA-strain features, compared to controls. sTTS was associated with increased laS_bp (12.7% versus 9.8%) and reduced lvEF (47.4% versus 54.8%), lvGLS (-12.2% versus 14.6%), and laS_cd (7.0% versus 9.5%) compared to cTTS (p ≤ 0.029). The interval between symptoms onset and CMR was correlated with laS_bp (r = -0.49) and lvGLS (r = 0.47) (p = 0.001 for both). At receiver operating characteristics analysis, laS_bp was the best discriminator between sTTS and cTTS (area under the curve [AUC] 0.815), followed by lvGLS (AUC 0.670). Conclusions LA dysfunction persists during the subacute and convalescence of TTS. laS_bp increases in subacute phase with progressive decrease during convalescence, representing a compensatory mechanism of LV dysfunction and thus a useful index of functional recovery. Relevance statement Atrial strain has the potential to enhance the delineation of cardiac injury and functional impairment in TTS patients, assisting in the identification of individuals at higher risk and facilitating the implementation of more targeted and personalized medical therapies. Key points • In TTS, after ventricular recovery, atrial dysfunction persists assessable with CMR feature tracking. • Quantitative assessment of atrial strain discriminates atrial functions: reservoir, conduit, and booster pump. • Atrial booster pump changes after acute TTS, regardless of ventricular function. • Atrial strain may serve as a temporal marker in TTS. Graphical Abstract |
| first_indexed | 2024-03-07T15:20:38Z |
| format | Article |
| id | doaj.art-199f36f3da9f481cb2a2c381a9401e74 |
| institution | Directory Open Access Journal |
| issn | 2509-9280 |
| language | English |
| last_indexed | 2024-03-07T15:20:38Z |
| publishDate | 2024-02-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | European Radiology Experimental |
| spelling | doaj.art-199f36f3da9f481cb2a2c381a9401e742024-03-05T17:38:20ZengSpringerOpenEuropean Radiology Experimental2509-92802024-02-018111510.1186/s41747-024-00423-7Takotsubo syndrome: left atrial and ventricular myocardial strain impairment in the subacute and convalescent phases assessed by CMRGiacomo Pambianchi0Livia Marchitelli1Giulia Cundari2Letizia Ruoli3Luca Conia4Carlo Catalano5Nicola Galea6Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome — Policlinico Umberto I HospitalDepartment of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome — Policlinico Umberto I HospitalDepartment of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome — Policlinico Umberto I HospitalDepartment of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome — Policlinico Umberto I HospitalDepartment of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome — Policlinico Umberto I HospitalDepartment of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome — Policlinico Umberto I HospitalDepartment of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome — Policlinico Umberto I HospitalAbstract Background We investigated the differences in impairment of left ventricle (LV) and left atrium (LA) contractile dysfunction between subacute and convalescent takotsubo syndrome (TTS), using myocardial strain analysis by cardiac magnetic resonance (CMR) feature-tracking technique. Methods We retrospectively selected 50 patients with TTS clinical-radiological diagnosis who underwent CMR within 30 days since symptoms onset: 19 studied during the early subacute phase (sTTS, ≤ 7 days) and 31 during the convalescence (cTTS, 8–30 days). We measured the following: LV global longitudinal, circumferential, and radial strain (lvGLS, lvGCS, lvGRS) and strain rate (SR) and LA reservoir (laS_r), conduit (laS_cd), and booster pump strain (laS_bp) and strain rate (laSR_r, laSR_cd, laSR_bp). Patients were compared with 30 age- and sex-matched controls. Results All patients were women (mean age 63 years). TTS patients showed altered LV- and LA-strain features, compared to controls. sTTS was associated with increased laS_bp (12.7% versus 9.8%) and reduced lvEF (47.4% versus 54.8%), lvGLS (-12.2% versus 14.6%), and laS_cd (7.0% versus 9.5%) compared to cTTS (p ≤ 0.029). The interval between symptoms onset and CMR was correlated with laS_bp (r = -0.49) and lvGLS (r = 0.47) (p = 0.001 for both). At receiver operating characteristics analysis, laS_bp was the best discriminator between sTTS and cTTS (area under the curve [AUC] 0.815), followed by lvGLS (AUC 0.670). Conclusions LA dysfunction persists during the subacute and convalescence of TTS. laS_bp increases in subacute phase with progressive decrease during convalescence, representing a compensatory mechanism of LV dysfunction and thus a useful index of functional recovery. Relevance statement Atrial strain has the potential to enhance the delineation of cardiac injury and functional impairment in TTS patients, assisting in the identification of individuals at higher risk and facilitating the implementation of more targeted and personalized medical therapies. Key points • In TTS, after ventricular recovery, atrial dysfunction persists assessable with CMR feature tracking. • Quantitative assessment of atrial strain discriminates atrial functions: reservoir, conduit, and booster pump. • Atrial booster pump changes after acute TTS, regardless of ventricular function. • Atrial strain may serve as a temporal marker in TTS. Graphical Abstracthttps://doi.org/10.1186/s41747-024-00423-7Atrial functionCardiac magnetic resonanceFemaleTakotsubo cardiomyopathyVentricular function |
| spellingShingle | Giacomo Pambianchi Livia Marchitelli Giulia Cundari Letizia Ruoli Luca Conia Carlo Catalano Nicola Galea Takotsubo syndrome: left atrial and ventricular myocardial strain impairment in the subacute and convalescent phases assessed by CMR European Radiology Experimental Atrial function Cardiac magnetic resonance Female Takotsubo cardiomyopathy Ventricular function |
| title | Takotsubo syndrome: left atrial and ventricular myocardial strain impairment in the subacute and convalescent phases assessed by CMR |
| title_full | Takotsubo syndrome: left atrial and ventricular myocardial strain impairment in the subacute and convalescent phases assessed by CMR |
| title_fullStr | Takotsubo syndrome: left atrial and ventricular myocardial strain impairment in the subacute and convalescent phases assessed by CMR |
| title_full_unstemmed | Takotsubo syndrome: left atrial and ventricular myocardial strain impairment in the subacute and convalescent phases assessed by CMR |
| title_short | Takotsubo syndrome: left atrial and ventricular myocardial strain impairment in the subacute and convalescent phases assessed by CMR |
| title_sort | takotsubo syndrome left atrial and ventricular myocardial strain impairment in the subacute and convalescent phases assessed by cmr |
| topic | Atrial function Cardiac magnetic resonance Female Takotsubo cardiomyopathy Ventricular function |
| url | https://doi.org/10.1186/s41747-024-00423-7 |
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