The rhythmic coupling of Egr-1 and Cidea regulates age-related metabolic dysfunction in the liver of male mice
Many transcriptomic pathways in the liver show circadian rhythms, which have been reported to be disrupted in aged mice. Here the authors report that the expression of transcription factor Egr-1 decreases and its rhythm is shifted with age in the liver of male mice, and that deletion of Egr-1 result...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-36775-8 |
| _version_ | 1827979422842486784 |
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| author | Jing Wu Dandan Bu Haiquan Wang Di Shen Danyang Chong Tongyu Zhang Weiwei Tao Mengfei Zhao Yue Zhao Lei Fang Peng Li Bin Xue Chao-Jun Li |
| author_facet | Jing Wu Dandan Bu Haiquan Wang Di Shen Danyang Chong Tongyu Zhang Weiwei Tao Mengfei Zhao Yue Zhao Lei Fang Peng Li Bin Xue Chao-Jun Li |
| author_sort | Jing Wu |
| collection | DOAJ |
| description | Many transcriptomic pathways in the liver show circadian rhythms, which have been reported to be disrupted in aged mice. Here the authors report that the expression of transcription factor Egr-1 decreases and its rhythm is shifted with age in the liver of male mice, and that deletion of Egr-1 results in increased liver fat accumulation. |
| first_indexed | 2024-04-09T21:36:31Z |
| format | Article |
| id | doaj.art-199f7c67ae4742889bff91445f4772d4 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-09T21:36:31Z |
| publishDate | 2023-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-199f7c67ae4742889bff91445f4772d42023-03-26T11:14:21ZengNature PortfolioNature Communications2041-17232023-03-0114111610.1038/s41467-023-36775-8The rhythmic coupling of Egr-1 and Cidea regulates age-related metabolic dysfunction in the liver of male miceJing Wu0Dandan Bu1Haiquan Wang2Di Shen3Danyang Chong4Tongyu Zhang5Weiwei Tao6Mengfei Zhao7Yue Zhao8Lei Fang9Peng Li10Bin Xue11Chao-Jun Li12Ministry of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center of the Medical School, Nanjing UniversityMinistry of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center of the Medical School, Nanjing UniversityMinistry of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center of the Medical School, Nanjing UniversityMinistry of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center of the Medical School, Nanjing UniversityMinistry of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center of the Medical School, Nanjing UniversityMinistry of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center of the Medical School, Nanjing UniversityState Key Laboratory of Reproductive Medicine and China International Joint Research Center on Environment and Human Health, Center for Global Health, School of Public Health, Nanjing Medical UniversityMinistry of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center of the Medical School, Nanjing UniversityMinistry of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center of the Medical School, Nanjing UniversityMinistry of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center of the Medical School, Nanjing UniversityInstitute of Metabolism & Integrative Biology (IMIB), Fudan UniversityCore Laboratory, Sir Run Run Hospital, Nanjing Medical UniversityState Key Laboratory of Reproductive Medicine and China International Joint Research Center on Environment and Human Health, Center for Global Health, School of Public Health, Nanjing Medical UniversityMany transcriptomic pathways in the liver show circadian rhythms, which have been reported to be disrupted in aged mice. Here the authors report that the expression of transcription factor Egr-1 decreases and its rhythm is shifted with age in the liver of male mice, and that deletion of Egr-1 results in increased liver fat accumulation.https://doi.org/10.1038/s41467-023-36775-8 |
| spellingShingle | Jing Wu Dandan Bu Haiquan Wang Di Shen Danyang Chong Tongyu Zhang Weiwei Tao Mengfei Zhao Yue Zhao Lei Fang Peng Li Bin Xue Chao-Jun Li The rhythmic coupling of Egr-1 and Cidea regulates age-related metabolic dysfunction in the liver of male mice Nature Communications |
| title | The rhythmic coupling of Egr-1 and Cidea regulates age-related metabolic dysfunction in the liver of male mice |
| title_full | The rhythmic coupling of Egr-1 and Cidea regulates age-related metabolic dysfunction in the liver of male mice |
| title_fullStr | The rhythmic coupling of Egr-1 and Cidea regulates age-related metabolic dysfunction in the liver of male mice |
| title_full_unstemmed | The rhythmic coupling of Egr-1 and Cidea regulates age-related metabolic dysfunction in the liver of male mice |
| title_short | The rhythmic coupling of Egr-1 and Cidea regulates age-related metabolic dysfunction in the liver of male mice |
| title_sort | rhythmic coupling of egr 1 and cidea regulates age related metabolic dysfunction in the liver of male mice |
| url | https://doi.org/10.1038/s41467-023-36775-8 |
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