A Novel Cellular Therapy to Treat Pancreatic Pain in Experimental Chronic Pancreatitis Using Human Alpha-1 Antitrypsin Overexpressing Mesenchymal Stromal Cells

A Novel Cellular Therapy to Treat Pancreatic Pain in Experimental Chronic Pancreatitis Using Human Alpha-1 Antitrypsin Overexpressing Mesenchymal Stromal Cells

Chronic pancreatitis (CP) is characterized by pancreatic inflammation, fibrosis, and abdominal pain that is challenging to treat. Mesenchymal stromal cells (MSCs) overexpressing human alpha-1 antitrypsin (hAAT-MSCs) showed improved mobility and protective functions over native MSCs in nonobese diabe...

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Bibliographic Details
Main Authors: Rebecca P. Chow, Kevin Nguyen, Wenyu Gou, Erica Green, Katherine Morgan, William Lancaster, Kristi Helke, Charlie Strange, Hongjun Wang
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Biomedicines
Subjects:
mesenchymal stromal cells
chronic pancreatitis
pain
inflammation
TRPV1
mast cells
Online Access:https://www.mdpi.com/2227-9059/9/11/1695

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