RETRACTED ARTICLE: MiRNA-211 suppresses cell proliferation, migration and invasion by targeting SPARC in human hepatocellular carcinoma
Abstract Previous studies have shown that the expression of miR-211 was downregulated in hepatocellular carcinoma (HCC). However, the molecular function and mechanism of miR-211 in HCC growth and invasion are largely unclear. We found that miR-211 is downregulated in HCC tissues and cell lines, resp...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2016-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/srep26679 |
| _version_ | 1827890365051437056 |
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| author | Biao Deng Lei Qu Jinfang Li Jiaqing Fang Shouwen Yang Zhongwei Cao Zhechuan Mei Xing Sun |
| author_facet | Biao Deng Lei Qu Jinfang Li Jiaqing Fang Shouwen Yang Zhongwei Cao Zhechuan Mei Xing Sun |
| author_sort | Biao Deng |
| collection | DOAJ |
| description | Abstract Previous studies have shown that the expression of miR-211 was downregulated in hepatocellular carcinoma (HCC). However, the molecular function and mechanism of miR-211 in HCC growth and invasion are largely unclear. We found that miR-211 is downregulated in HCC tissues and cell lines, respectively. Further results showed that low miR-211 associated with TNM stage, vein invasion status and poor prognosis. Ectopic expression of miR-211 effectively suppressed HCC cell proliferation, migration and invasion both in vitro and in vivo. We identified SPARC as a bona fide target of miR-211 and overexpression of miR-211 decreased the mRNA and protein expression of SPARC. Finally, we confirmed that the overexpression of SPARC in miR-211-expressing HCC cells can partially restore the inhibitory effect of miR-211. Taken together, our results demonstrated that loss of miR-211 expression and thus uncontrolled SPARC overexpression might drive progression of HCC, which may provide a novel therapeutic strategy for the treatment of HCC. |
| first_indexed | 2024-03-12T21:08:42Z |
| format | Article |
| id | doaj.art-19a3f3f4aeab48e8aed37aa337785f9c |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-12T21:08:42Z |
| publishDate | 2016-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-19a3f3f4aeab48e8aed37aa337785f9c2023-07-30T11:16:13ZengNature PortfolioScientific Reports2045-23222016-05-016111210.1038/srep26679RETRACTED ARTICLE: MiRNA-211 suppresses cell proliferation, migration and invasion by targeting SPARC in human hepatocellular carcinomaBiao Deng0Lei Qu1Jinfang Li2Jiaqing Fang3Shouwen Yang4Zhongwei Cao5Zhechuan Mei6Xing Sun7Department of General Surgery, Shanghai First People’s Hospital, Shanghai Jiao Tong UniversityDepartment of General Surgery, Shanghai First People’s Hospital, Shanghai Jiao Tong UniversityDepartment of Neurology, The Second Affiliated Hospital, Chongqing Medical UniversityDepartment of Gastroenterology, Tianyou Hospital, TongJi UniversityDepartment of General Surgery, Shanghai First People’s Hospital, Shanghai Jiao Tong UniversityDepartment of Gastroenterology, Shanghai First People’s Hospital, Shanghai Jiao Tong UniversityDepartment of Gastroenterology, The Second Affiliated Hospital, Chongqing Medical UniversityDepartment of General Surgery, Shanghai First People’s Hospital, Shanghai Jiao Tong UniversityAbstract Previous studies have shown that the expression of miR-211 was downregulated in hepatocellular carcinoma (HCC). However, the molecular function and mechanism of miR-211 in HCC growth and invasion are largely unclear. We found that miR-211 is downregulated in HCC tissues and cell lines, respectively. Further results showed that low miR-211 associated with TNM stage, vein invasion status and poor prognosis. Ectopic expression of miR-211 effectively suppressed HCC cell proliferation, migration and invasion both in vitro and in vivo. We identified SPARC as a bona fide target of miR-211 and overexpression of miR-211 decreased the mRNA and protein expression of SPARC. Finally, we confirmed that the overexpression of SPARC in miR-211-expressing HCC cells can partially restore the inhibitory effect of miR-211. Taken together, our results demonstrated that loss of miR-211 expression and thus uncontrolled SPARC overexpression might drive progression of HCC, which may provide a novel therapeutic strategy for the treatment of HCC.https://doi.org/10.1038/srep26679 |
| spellingShingle | Biao Deng Lei Qu Jinfang Li Jiaqing Fang Shouwen Yang Zhongwei Cao Zhechuan Mei Xing Sun RETRACTED ARTICLE: MiRNA-211 suppresses cell proliferation, migration and invasion by targeting SPARC in human hepatocellular carcinoma Scientific Reports |
| title | RETRACTED ARTICLE: MiRNA-211 suppresses cell proliferation, migration and invasion by targeting SPARC in human hepatocellular carcinoma |
| title_full | RETRACTED ARTICLE: MiRNA-211 suppresses cell proliferation, migration and invasion by targeting SPARC in human hepatocellular carcinoma |
| title_fullStr | RETRACTED ARTICLE: MiRNA-211 suppresses cell proliferation, migration and invasion by targeting SPARC in human hepatocellular carcinoma |
| title_full_unstemmed | RETRACTED ARTICLE: MiRNA-211 suppresses cell proliferation, migration and invasion by targeting SPARC in human hepatocellular carcinoma |
| title_short | RETRACTED ARTICLE: MiRNA-211 suppresses cell proliferation, migration and invasion by targeting SPARC in human hepatocellular carcinoma |
| title_sort | retracted article mirna 211 suppresses cell proliferation migration and invasion by targeting sparc in human hepatocellular carcinoma |
| url | https://doi.org/10.1038/srep26679 |
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