Taurine increases hippocampal neurogenesis in aging mice
Aging is associated with increased inflammation and reduced hippocampal neurogenesis, which may in turn contribute to cognitive impairment. Taurine is a free amino acid found in numerous diets, with anti-inflammatory properties. Although abundant in the young brain, the decrease in taurine concentra...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2015-05-01
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| Series: | Stem Cell Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1873506115000434 |
| _version_ | 1819083500421120000 |
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| author | Elias Gebara Florian Udry Sébastien Sultan Nicolas Toni |
| author_facet | Elias Gebara Florian Udry Sébastien Sultan Nicolas Toni |
| author_sort | Elias Gebara |
| collection | DOAJ |
| description | Aging is associated with increased inflammation and reduced hippocampal neurogenesis, which may in turn contribute to cognitive impairment. Taurine is a free amino acid found in numerous diets, with anti-inflammatory properties. Although abundant in the young brain, the decrease in taurine concentration with age may underlie reduced neurogenesis. Here, we assessed the effect of taurine on hippocampal neurogenesis in middle-aged mice. We found that taurine increased cell proliferation in the dentate gyrus through the activation of quiescent stem cells, resulting in increased number of stem cells and intermediate neural progenitors. Taurine had a direct effect on stem/progenitor cells proliferation, as observed in vitro, and also reduced activated microglia. Furthermore, taurine increased the survival of newborn neurons, resulting in a net increase in adult neurogenesis. Together, these results show that taurine increases several steps of adult neurogenesis and support a beneficial role of taurine on hippocampal neurogenesis in the context of brain aging. |
| first_indexed | 2024-12-21T20:33:33Z |
| format | Article |
| id | doaj.art-19a57595d139409cb6d2c613dd3adb9f |
| institution | Directory Open Access Journal |
| issn | 1873-5061 1876-7753 |
| language | English |
| last_indexed | 2024-12-21T20:33:33Z |
| publishDate | 2015-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Stem Cell Research |
| spelling | doaj.art-19a57595d139409cb6d2c613dd3adb9f2022-12-21T18:51:10ZengElsevierStem Cell Research1873-50611876-77532015-05-0114336937910.1016/j.scr.2015.04.001Taurine increases hippocampal neurogenesis in aging miceElias GebaraFlorian UdrySébastien SultanNicolas ToniAging is associated with increased inflammation and reduced hippocampal neurogenesis, which may in turn contribute to cognitive impairment. Taurine is a free amino acid found in numerous diets, with anti-inflammatory properties. Although abundant in the young brain, the decrease in taurine concentration with age may underlie reduced neurogenesis. Here, we assessed the effect of taurine on hippocampal neurogenesis in middle-aged mice. We found that taurine increased cell proliferation in the dentate gyrus through the activation of quiescent stem cells, resulting in increased number of stem cells and intermediate neural progenitors. Taurine had a direct effect on stem/progenitor cells proliferation, as observed in vitro, and also reduced activated microglia. Furthermore, taurine increased the survival of newborn neurons, resulting in a net increase in adult neurogenesis. Together, these results show that taurine increases several steps of adult neurogenesis and support a beneficial role of taurine on hippocampal neurogenesis in the context of brain aging.http://www.sciencedirect.com/science/article/pii/S1873506115000434 |
| spellingShingle | Elias Gebara Florian Udry Sébastien Sultan Nicolas Toni Taurine increases hippocampal neurogenesis in aging mice Stem Cell Research |
| title | Taurine increases hippocampal neurogenesis in aging mice |
| title_full | Taurine increases hippocampal neurogenesis in aging mice |
| title_fullStr | Taurine increases hippocampal neurogenesis in aging mice |
| title_full_unstemmed | Taurine increases hippocampal neurogenesis in aging mice |
| title_short | Taurine increases hippocampal neurogenesis in aging mice |
| title_sort | taurine increases hippocampal neurogenesis in aging mice |
| url | http://www.sciencedirect.com/science/article/pii/S1873506115000434 |
| work_keys_str_mv | AT eliasgebara taurineincreaseshippocampalneurogenesisinagingmice AT florianudry taurineincreaseshippocampalneurogenesisinagingmice AT sebastiensultan taurineincreaseshippocampalneurogenesisinagingmice AT nicolastoni taurineincreaseshippocampalneurogenesisinagingmice |