Perspectives on the translation of in-vitro studies to precision medicine in Cystic Fibrosis

Perspectives on the translation of in-vitro studies to precision medicine in Cystic Fibrosis

Recent strides towards precision medicine in Cystic Fibrosis (CF) have been made possible by patient-derived in-vitro assays with the potential to predict clinical response to small molecule-based therapies. Here, we discuss the status of primary and stem-cell derived tissues used to evaluate the pr...

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Bibliographic Details
Main Authors: Marie-Pier Dumas, Sunny Xia, Christine E. Bear, Felix Ratjen
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:EBioMedicine
Subjects:
Cystic Fibrosis
CFTR modulators
Outcome measures
In-vitro models
Primary tissue
Organoids
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396421004540

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