Pharmacological inhibition of Mint3 attenuates tumour growth, metastasis, and endotoxic shock
Sakomoto et al. identify naphthofluorescein as a mint3 inhibitor that disrupts the Mint3–FIH-1 interaction and attenuates HIF-1 activity. In vivo experiments in mice reveal a reduction in tumor growth with attenuated inflammatory cytokine production and endotoxic shock, presenting an option for targ...
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Bibliographic Details
| Main Authors: |
Takeharu Sakamoto,
Yuya Fukui,
Yasumitsu Kondoh,
Kaori Honda,
Takeshi Shimizu,
Toshiro Hara,
Tetsuro Hayashi,
Yurika Saitoh,
Yoshinori Murakami,
Jun-ichiro Inoue,
Shuichi Kaneko,
Hiroyuki Osada,
Motoharu Seiki |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2021-10-01
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| Series: | Communications Biology
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| Online Access: | https://doi.org/10.1038/s42003-021-02701-1
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