Clickable Biomaterials for Modulating Neuroinflammation
Crosstalk between the nervous and immune systems in the context of trauma or disease can lead to a state of neuroinflammation or excessive recruitment and activation of peripheral and central immune cells. Neuroinflammation is an underlying and contributing factor to myriad neuropathologies includin...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/15/8496 |
| _version_ | 1797413634973892608 |
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| author | Chase Cornelison Sherly Fadel |
| author_facet | Chase Cornelison Sherly Fadel |
| author_sort | Chase Cornelison |
| collection | DOAJ |
| description | Crosstalk between the nervous and immune systems in the context of trauma or disease can lead to a state of neuroinflammation or excessive recruitment and activation of peripheral and central immune cells. Neuroinflammation is an underlying and contributing factor to myriad neuropathologies including neurodegenerative diseases like Alzheimer’s disease and Parkinson’s disease; autoimmune diseases like multiple sclerosis; peripheral and central nervous system infections; and ischemic and traumatic neural injuries. Therapeutic modulation of immune cell function is an emerging strategy to quell neuroinflammation and promote tissue homeostasis and/or repair. One such branch of ‘immunomodulation’ leverages the versatility of biomaterials to regulate immune cell phenotypes through direct cell-material interactions or targeted release of therapeutic payloads. In this regard, a growing trend in biomaterial science is the functionalization of materials using chemistries that do not interfere with biological processes, so-called ‘click’ or bioorthogonal reactions. Bioorthogonal chemistries such as Michael-type additions, thiol-ene reactions, and Diels-Alder reactions are highly specific and can be used in the presence of live cells for material crosslinking, decoration, protein or cell targeting, and spatiotemporal modification. Hence, click-based biomaterials can be highly bioactive and instruct a variety of cellular functions, even within the context of neuroinflammation. This manuscript will review recent advances in the application of click-based biomaterials for treating neuroinflammation and promoting neural tissue repair. |
| first_indexed | 2024-03-09T05:20:51Z |
| format | Article |
| id | doaj.art-19ac5fc235a0497ebf79d060e2f9925f |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T05:20:51Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-19ac5fc235a0497ebf79d060e2f9925f2023-12-03T12:40:18ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-07-012315849610.3390/ijms23158496Clickable Biomaterials for Modulating NeuroinflammationChase Cornelison0Sherly Fadel1Department of Biomedical Engineering, University of Massachusetts Amherst, Amherst, MA 01003, USADepartment of Biomedical Engineering, University of Massachusetts Amherst, Amherst, MA 01003, USACrosstalk between the nervous and immune systems in the context of trauma or disease can lead to a state of neuroinflammation or excessive recruitment and activation of peripheral and central immune cells. Neuroinflammation is an underlying and contributing factor to myriad neuropathologies including neurodegenerative diseases like Alzheimer’s disease and Parkinson’s disease; autoimmune diseases like multiple sclerosis; peripheral and central nervous system infections; and ischemic and traumatic neural injuries. Therapeutic modulation of immune cell function is an emerging strategy to quell neuroinflammation and promote tissue homeostasis and/or repair. One such branch of ‘immunomodulation’ leverages the versatility of biomaterials to regulate immune cell phenotypes through direct cell-material interactions or targeted release of therapeutic payloads. In this regard, a growing trend in biomaterial science is the functionalization of materials using chemistries that do not interfere with biological processes, so-called ‘click’ or bioorthogonal reactions. Bioorthogonal chemistries such as Michael-type additions, thiol-ene reactions, and Diels-Alder reactions are highly specific and can be used in the presence of live cells for material crosslinking, decoration, protein or cell targeting, and spatiotemporal modification. Hence, click-based biomaterials can be highly bioactive and instruct a variety of cellular functions, even within the context of neuroinflammation. This manuscript will review recent advances in the application of click-based biomaterials for treating neuroinflammation and promoting neural tissue repair.https://www.mdpi.com/1422-0067/23/15/8496biomaterialscaffoldparticlesbioorthogonalclick chemistryimmunomodulation |
| spellingShingle | Chase Cornelison Sherly Fadel Clickable Biomaterials for Modulating Neuroinflammation International Journal of Molecular Sciences biomaterial scaffold particles bioorthogonal click chemistry immunomodulation |
| title | Clickable Biomaterials for Modulating Neuroinflammation |
| title_full | Clickable Biomaterials for Modulating Neuroinflammation |
| title_fullStr | Clickable Biomaterials for Modulating Neuroinflammation |
| title_full_unstemmed | Clickable Biomaterials for Modulating Neuroinflammation |
| title_short | Clickable Biomaterials for Modulating Neuroinflammation |
| title_sort | clickable biomaterials for modulating neuroinflammation |
| topic | biomaterial scaffold particles bioorthogonal click chemistry immunomodulation |
| url | https://www.mdpi.com/1422-0067/23/15/8496 |
| work_keys_str_mv | AT chasecornelison clickablebiomaterialsformodulatingneuroinflammation AT sherlyfadel clickablebiomaterialsformodulatingneuroinflammation |