Effects of polycyclic aromatic hydrocarbons (PAHs) on pregnancy, placenta, and placental trophoblasts
Polycyclic aromatic hydrocarbons (PAHs) are a group of persistent organic pollutants that are carcinogenic, mutagenic, endocrine-toxic, and immunotoxic. PAHs can be found in maternal and fetal blood and in the placenta during pregnancy. They may thus affect placental and fetal development. Therefore...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-09-01
|
| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651323008187 |
| _version_ | 1827866460773416960 |
|---|---|
| author | Yifeng Dai Xijin Xu Xia Huo Marijke M. Faas |
| author_facet | Yifeng Dai Xijin Xu Xia Huo Marijke M. Faas |
| author_sort | Yifeng Dai |
| collection | DOAJ |
| description | Polycyclic aromatic hydrocarbons (PAHs) are a group of persistent organic pollutants that are carcinogenic, mutagenic, endocrine-toxic, and immunotoxic. PAHs can be found in maternal and fetal blood and in the placenta during pregnancy. They may thus affect placental and fetal development. Therefore, the exposure levels and toxic effects of PAHs in the placenta deserve further study and discussion. This review aims to summarize current knowledge on the effects of PAHs and their metabolites on pregnancy and birth outcomes and on placental trophoblast cells. A growing number of epidemiological studies detected PAH-DNA adducts as well as the 16 high-priority PAHs in the human placenta and showed that placental PAH exposure is associated with adverse fetal outcomes. Trophoblasts are important cells in the placenta and are involved in placental development and function. In vitro studies have shown that exposure to either PAH mixtures, benzo(a)pyrene (BaP) or BaP metabolite benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE) affected trophoblast cell viability, differentiation, migration, and invasion through various signaling pathways. Furthermore, similar effects of BPDE on trophoblast cells could also be observed in BaP-treated mouse models and were related to miscarriage. Although the current data show that PAHs may affect placental trophoblast cells and pregnancy outcomes, further studies (population studies, in vitro studies, and animal studies) are necessary to show the specific effects of different PAHs on placental trophoblasts and pregnancy outcomes. |
| first_indexed | 2024-03-12T15:05:04Z |
| format | Article |
| id | doaj.art-19aca90eeefa4bb5891c1df14a628c7d |
| institution | Directory Open Access Journal |
| issn | 0147-6513 |
| language | English |
| last_indexed | 2024-03-12T15:05:04Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj.art-19aca90eeefa4bb5891c1df14a628c7d2023-08-13T04:52:03ZengElsevierEcotoxicology and Environmental Safety0147-65132023-09-01262115314Effects of polycyclic aromatic hydrocarbons (PAHs) on pregnancy, placenta, and placental trophoblastsYifeng Dai0Xijin Xu1Xia Huo2Marijke M. Faas3Division of Medical Biology, Department of Pathology and Medical Biology, University Medical Center Groningen and University of Groningen, Hanzeplein 1, 9713 GZ Groningen, the Netherlands; Laboratory of Environmental Medicine and Developmental Toxicology, Shantou University Medical College, 22 Xinling Rd, Shantou 515041, Guangdong, China; Corresponding author at: Division of Medical Biology, Department of Pathology and Medical Biology, University Medical Center Groningen and University of Groningen, Hanzeplein 1, 9713 GZ Groningen, the Netherlands.Laboratory of Environmental Medicine and Developmental Toxicology, Shantou University Medical College, 22 Xinling Rd, Shantou 515041, Guangdong, China; Department of Cell Biology and Genetics, Shantou University Medical College, 22 Xinling Rd, Shantou 515041, Guangdong, ChinaLaboratory of Environmental Medicine and Developmental Toxicology, Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment, Jinan University, Guangzhou 510632, Guangdong, ChinaDivision of Medical Biology, Department of Pathology and Medical Biology, University Medical Center Groningen and University of Groningen, Hanzeplein 1, 9713 GZ Groningen, the Netherlands; Department of Obstetrics and Gynecology, University Medical Center Groningen and University of Groningen, Hanzeplein 1, 9713 GZ Groningen, the NetherlandsPolycyclic aromatic hydrocarbons (PAHs) are a group of persistent organic pollutants that are carcinogenic, mutagenic, endocrine-toxic, and immunotoxic. PAHs can be found in maternal and fetal blood and in the placenta during pregnancy. They may thus affect placental and fetal development. Therefore, the exposure levels and toxic effects of PAHs in the placenta deserve further study and discussion. This review aims to summarize current knowledge on the effects of PAHs and their metabolites on pregnancy and birth outcomes and on placental trophoblast cells. A growing number of epidemiological studies detected PAH-DNA adducts as well as the 16 high-priority PAHs in the human placenta and showed that placental PAH exposure is associated with adverse fetal outcomes. Trophoblasts are important cells in the placenta and are involved in placental development and function. In vitro studies have shown that exposure to either PAH mixtures, benzo(a)pyrene (BaP) or BaP metabolite benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE) affected trophoblast cell viability, differentiation, migration, and invasion through various signaling pathways. Furthermore, similar effects of BPDE on trophoblast cells could also be observed in BaP-treated mouse models and were related to miscarriage. Although the current data show that PAHs may affect placental trophoblast cells and pregnancy outcomes, further studies (population studies, in vitro studies, and animal studies) are necessary to show the specific effects of different PAHs on placental trophoblasts and pregnancy outcomes.http://www.sciencedirect.com/science/article/pii/S0147651323008187PAHsBaPBPDEExposureToxicologyPregnancy |
| spellingShingle | Yifeng Dai Xijin Xu Xia Huo Marijke M. Faas Effects of polycyclic aromatic hydrocarbons (PAHs) on pregnancy, placenta, and placental trophoblasts Ecotoxicology and Environmental Safety PAHs BaP BPDE Exposure Toxicology Pregnancy |
| title | Effects of polycyclic aromatic hydrocarbons (PAHs) on pregnancy, placenta, and placental trophoblasts |
| title_full | Effects of polycyclic aromatic hydrocarbons (PAHs) on pregnancy, placenta, and placental trophoblasts |
| title_fullStr | Effects of polycyclic aromatic hydrocarbons (PAHs) on pregnancy, placenta, and placental trophoblasts |
| title_full_unstemmed | Effects of polycyclic aromatic hydrocarbons (PAHs) on pregnancy, placenta, and placental trophoblasts |
| title_short | Effects of polycyclic aromatic hydrocarbons (PAHs) on pregnancy, placenta, and placental trophoblasts |
| title_sort | effects of polycyclic aromatic hydrocarbons pahs on pregnancy placenta and placental trophoblasts |
| topic | PAHs BaP BPDE Exposure Toxicology Pregnancy |
| url | http://www.sciencedirect.com/science/article/pii/S0147651323008187 |
| work_keys_str_mv | AT yifengdai effectsofpolycyclicaromatichydrocarbonspahsonpregnancyplacentaandplacentaltrophoblasts AT xijinxu effectsofpolycyclicaromatichydrocarbonspahsonpregnancyplacentaandplacentaltrophoblasts AT xiahuo effectsofpolycyclicaromatichydrocarbonspahsonpregnancyplacentaandplacentaltrophoblasts AT marijkemfaas effectsofpolycyclicaromatichydrocarbonspahsonpregnancyplacentaandplacentaltrophoblasts |