Construction and validation of an NAD + metabolism-related lncRNA signature for predicting the prognosis and immune landscape of acute myeloid leukemia
Background This study aimed to investigate the potential of a NAD+ metabolism-related lncRNA signature as a reliable prognostic biomarker for acute myeloid leukemia (AML).Methods Transcriptome profiles and clinical data of AML patients were obtained from The Cancer Genome Atlas (TCGA) database. NAD+...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2023-12-01
|
| Series: | Hematology |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/16078454.2023.2231760 |
| _version_ | 1797785286945538048 |
|---|---|
| author | Yu Zhu Jinli Jian Yujie Niu Xiaoxiao Yang Yuancheng Guo Long Zhao Bei Liu |
| author_facet | Yu Zhu Jinli Jian Yujie Niu Xiaoxiao Yang Yuancheng Guo Long Zhao Bei Liu |
| author_sort | Yu Zhu |
| collection | DOAJ |
| description | Background This study aimed to investigate the potential of a NAD+ metabolism-related lncRNA signature as a reliable prognostic biomarker for acute myeloid leukemia (AML).Methods Transcriptome profiles and clinical data of AML patients were obtained from The Cancer Genome Atlas (TCGA) database. NAD+ metabolism-related genes (NMRGs) were identified from the KEGG and Reactome databases. Coexpression analysis was used to screen NAD+ metabolism-related lncRNAs. The NAD+ metabolismrelated lncRNA signature was constructed using univariate analysis, LASSO regression, and multivariate analysis. High- and low-risk groups were compared for survival, tumor mutation burden, immune cell infiltration, and response to immunotherapy. Enrichment analysis explored the biological functions.Results LINC01679, AC079922.2, TRAF3IP2-AS1, and LINC02465 were identified to construct the risk model. The model exhibited good predictive power and outperformed age and gender as an independent prognostic marker. High-risk patients showed poorer survival, distinct TP53 mutations, and altered immune cell infiltration compared to low-risk patients. Additionally, low-risk patients exhibited greater sensitivity to immunotherapy. Enriched biological functions included leukocyte migration and positive regulation of cytokine production.Conclusions The NAD+ metabolism-related lncRNA signature shows promise in predicting clinical outcomes for AML patients. |
| first_indexed | 2024-03-13T00:51:56Z |
| format | Article |
| id | doaj.art-19adeb2063f14407bb05f325c8889fab |
| institution | Directory Open Access Journal |
| issn | 1607-8454 |
| language | English |
| last_indexed | 2024-03-13T00:51:56Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Hematology |
| spelling | doaj.art-19adeb2063f14407bb05f325c8889fab2023-07-07T10:52:23ZengTaylor & Francis GroupHematology1607-84542023-12-0128110.1080/16078454.2023.2231760Construction and validation of an NAD + metabolism-related lncRNA signature for predicting the prognosis and immune landscape of acute myeloid leukemiaYu Zhu0Jinli Jian1Yujie Niu2Xiaoxiao Yang3Yuancheng Guo4Long Zhao5Bei Liu6The First Clinical Medical College, Lanzhou University, Lanzhou, People’s Republic of ChinaThe First Clinical Medical College, Lanzhou University, Lanzhou, People’s Republic of ChinaThe First Clinical Medical College, Lanzhou University, Lanzhou, People’s Republic of ChinaThe First Clinical Medical College, Lanzhou University, Lanzhou, People’s Republic of ChinaThe First Clinical Medical College, Lanzhou University, Lanzhou, People’s Republic of ChinaThe First Clinical Medical College, Lanzhou University, Lanzhou, People’s Republic of ChinaThe First Clinical Medical College, Lanzhou University, Lanzhou, People’s Republic of ChinaBackground This study aimed to investigate the potential of a NAD+ metabolism-related lncRNA signature as a reliable prognostic biomarker for acute myeloid leukemia (AML).Methods Transcriptome profiles and clinical data of AML patients were obtained from The Cancer Genome Atlas (TCGA) database. NAD+ metabolism-related genes (NMRGs) were identified from the KEGG and Reactome databases. Coexpression analysis was used to screen NAD+ metabolism-related lncRNAs. The NAD+ metabolismrelated lncRNA signature was constructed using univariate analysis, LASSO regression, and multivariate analysis. High- and low-risk groups were compared for survival, tumor mutation burden, immune cell infiltration, and response to immunotherapy. Enrichment analysis explored the biological functions.Results LINC01679, AC079922.2, TRAF3IP2-AS1, and LINC02465 were identified to construct the risk model. The model exhibited good predictive power and outperformed age and gender as an independent prognostic marker. High-risk patients showed poorer survival, distinct TP53 mutations, and altered immune cell infiltration compared to low-risk patients. Additionally, low-risk patients exhibited greater sensitivity to immunotherapy. Enriched biological functions included leukocyte migration and positive regulation of cytokine production.Conclusions The NAD+ metabolism-related lncRNA signature shows promise in predicting clinical outcomes for AML patients.https://www.tandfonline.com/doi/10.1080/16078454.2023.2231760Acute myeloid leukemia1NAD+ metabolism2prognostic signature3immune landscape4lncRNA5 |
| spellingShingle | Yu Zhu Jinli Jian Yujie Niu Xiaoxiao Yang Yuancheng Guo Long Zhao Bei Liu Construction and validation of an NAD + metabolism-related lncRNA signature for predicting the prognosis and immune landscape of acute myeloid leukemia Hematology Acute myeloid leukemia1 NAD+ metabolism2 prognostic signature3 immune landscape4 lncRNA5 |
| title | Construction and validation of an NAD + metabolism-related lncRNA signature for predicting the prognosis and immune landscape of acute myeloid leukemia |
| title_full | Construction and validation of an NAD + metabolism-related lncRNA signature for predicting the prognosis and immune landscape of acute myeloid leukemia |
| title_fullStr | Construction and validation of an NAD + metabolism-related lncRNA signature for predicting the prognosis and immune landscape of acute myeloid leukemia |
| title_full_unstemmed | Construction and validation of an NAD + metabolism-related lncRNA signature for predicting the prognosis and immune landscape of acute myeloid leukemia |
| title_short | Construction and validation of an NAD + metabolism-related lncRNA signature for predicting the prognosis and immune landscape of acute myeloid leukemia |
| title_sort | construction and validation of an nad metabolism related lncrna signature for predicting the prognosis and immune landscape of acute myeloid leukemia |
| topic | Acute myeloid leukemia1 NAD+ metabolism2 prognostic signature3 immune landscape4 lncRNA5 |
| url | https://www.tandfonline.com/doi/10.1080/16078454.2023.2231760 |
| work_keys_str_mv | AT yuzhu constructionandvalidationofannadmetabolismrelatedlncrnasignatureforpredictingtheprognosisandimmunelandscapeofacutemyeloidleukemia AT jinlijian constructionandvalidationofannadmetabolismrelatedlncrnasignatureforpredictingtheprognosisandimmunelandscapeofacutemyeloidleukemia AT yujieniu constructionandvalidationofannadmetabolismrelatedlncrnasignatureforpredictingtheprognosisandimmunelandscapeofacutemyeloidleukemia AT xiaoxiaoyang constructionandvalidationofannadmetabolismrelatedlncrnasignatureforpredictingtheprognosisandimmunelandscapeofacutemyeloidleukemia AT yuanchengguo constructionandvalidationofannadmetabolismrelatedlncrnasignatureforpredictingtheprognosisandimmunelandscapeofacutemyeloidleukemia AT longzhao constructionandvalidationofannadmetabolismrelatedlncrnasignatureforpredictingtheprognosisandimmunelandscapeofacutemyeloidleukemia AT beiliu constructionandvalidationofannadmetabolismrelatedlncrnasignatureforpredictingtheprognosisandimmunelandscapeofacutemyeloidleukemia |