The burden of Burkitt lymphoma in Africa
Abstract Background Burkitt lymphoma (BL) is a relatively common cancer of childhood in tropical Africa, although its precise incidence and continent-wide geographic distribution have not been previously systematically studied. Methods Using the methods employed to produce national estimates of canc...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2019-08-01
|
| Series: | Infectious Agents and Cancer |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13027-019-0236-7 |
| _version_ | 1818242859780800512 |
|---|---|
| author | Lucia Hämmerl Murielle Colombet Rosemary Rochford David Martin Ogwang Donald Maxwell Parkin |
| author_facet | Lucia Hämmerl Murielle Colombet Rosemary Rochford David Martin Ogwang Donald Maxwell Parkin |
| author_sort | Lucia Hämmerl |
| collection | DOAJ |
| description | Abstract Background Burkitt lymphoma (BL) is a relatively common cancer of childhood in tropical Africa, although its precise incidence and continent-wide geographic distribution have not been previously systematically studied. Methods Using the methods employed to produce national estimates of cancer incidence for the “Globocan” series of the International Agency for Research on Cancer, along with detailed information on cancer incidence by histological subtype from cancer registries in Africa, we estimate the numbers and rates of incidence by sex, age group, country and region of Africa. Results We estimate that the number of new cases that occurred in 2018 to be about 3900, two thirds in males, and 81% in children aged 0–14. On a national basis, the geographic distribution of incidence rates among children in sub-Saharan Africa resembles that of the prevalence of infection with Falciparum malaria. An estimated 81% of cases are associated with infection with Epstein Barr virus (EBV). Conclusions BL comprises almost 50% of childhood of non-Hodgkin lymphoma in Africa, almost all of which are associated with EBV, with the geographic distribution – at least in sub Saharan Africa - mediated by infection with malaria. |
| first_indexed | 2024-12-12T13:51:56Z |
| format | Article |
| id | doaj.art-19ae6e919b914172860617f6d7e6209d |
| institution | Directory Open Access Journal |
| issn | 1750-9378 |
| language | English |
| last_indexed | 2024-12-12T13:51:56Z |
| publishDate | 2019-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Infectious Agents and Cancer |
| spelling | doaj.art-19ae6e919b914172860617f6d7e6209d2022-12-22T00:22:32ZengBMCInfectious Agents and Cancer1750-93782019-08-011411610.1186/s13027-019-0236-7The burden of Burkitt lymphoma in AfricaLucia Hämmerl0Murielle Colombet1Rosemary Rochford2David Martin Ogwang3Donald Maxwell Parkin4Institute of Medical Epidemiology, Biometrics and Informatics, Medical Faculty of Martin Luther University Halle-Wittenberg GermanySection of Cancer Information, International Agency for Research on CancerDepartment of Immunology and Microbiology, University of Colorado Anschutz Medical CampusGulu Cancer Registry, St. Mary’s Hospital LacorNuffield Department of Population Health, University of OxfordAbstract Background Burkitt lymphoma (BL) is a relatively common cancer of childhood in tropical Africa, although its precise incidence and continent-wide geographic distribution have not been previously systematically studied. Methods Using the methods employed to produce national estimates of cancer incidence for the “Globocan” series of the International Agency for Research on Cancer, along with detailed information on cancer incidence by histological subtype from cancer registries in Africa, we estimate the numbers and rates of incidence by sex, age group, country and region of Africa. Results We estimate that the number of new cases that occurred in 2018 to be about 3900, two thirds in males, and 81% in children aged 0–14. On a national basis, the geographic distribution of incidence rates among children in sub-Saharan Africa resembles that of the prevalence of infection with Falciparum malaria. An estimated 81% of cases are associated with infection with Epstein Barr virus (EBV). Conclusions BL comprises almost 50% of childhood of non-Hodgkin lymphoma in Africa, almost all of which are associated with EBV, with the geographic distribution – at least in sub Saharan Africa - mediated by infection with malaria.http://link.springer.com/article/10.1186/s13027-019-0236-7Burkitt lymphomaAfricaEpstein Barr virusEpidemiologyIncidence |
| spellingShingle | Lucia Hämmerl Murielle Colombet Rosemary Rochford David Martin Ogwang Donald Maxwell Parkin The burden of Burkitt lymphoma in Africa Infectious Agents and Cancer Burkitt lymphoma Africa Epstein Barr virus Epidemiology Incidence |
| title | The burden of Burkitt lymphoma in Africa |
| title_full | The burden of Burkitt lymphoma in Africa |
| title_fullStr | The burden of Burkitt lymphoma in Africa |
| title_full_unstemmed | The burden of Burkitt lymphoma in Africa |
| title_short | The burden of Burkitt lymphoma in Africa |
| title_sort | burden of burkitt lymphoma in africa |
| topic | Burkitt lymphoma Africa Epstein Barr virus Epidemiology Incidence |
| url | http://link.springer.com/article/10.1186/s13027-019-0236-7 |
| work_keys_str_mv | AT luciahammerl theburdenofburkittlymphomainafrica AT muriellecolombet theburdenofburkittlymphomainafrica AT rosemaryrochford theburdenofburkittlymphomainafrica AT davidmartinogwang theburdenofburkittlymphomainafrica AT donaldmaxwellparkin theburdenofburkittlymphomainafrica AT luciahammerl burdenofburkittlymphomainafrica AT muriellecolombet burdenofburkittlymphomainafrica AT rosemaryrochford burdenofburkittlymphomainafrica AT davidmartinogwang burdenofburkittlymphomainafrica AT donaldmaxwellparkin burdenofburkittlymphomainafrica |