Role of the microbiome in pathophysiology of necrotising enterocolitis in preterm neonates
Although necrotising enterocolitis (NEC) is a serious, life-threatening disease, improved neonatal care is increasing the number of survivors with NEC among extremely preterm neonates. Therapy is nevertheless mostly symptomatic and the mortality rate remains high, especially among neonates requiring...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2023-12-01
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| Series: | BMJ Paediatrics Open |
| Online Access: | https://bmjpaedsopen.bmj.com/content/7/1/e002172.full |
| _version_ | 1797371122701828096 |
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| author | Ondrej Slaby Andrea Stanikova Martin Jouza Julia Bohosova Petr Jabandziev |
| author_facet | Ondrej Slaby Andrea Stanikova Martin Jouza Julia Bohosova Petr Jabandziev |
| author_sort | Ondrej Slaby |
| collection | DOAJ |
| description | Although necrotising enterocolitis (NEC) is a serious, life-threatening disease, improved neonatal care is increasing the number of survivors with NEC among extremely preterm neonates. Therapy is nevertheless mostly symptomatic and the mortality rate remains high, especially among neonates requiring surgery. Therefore, it is important to focus on preventing the disease and modifiable risk factors. NEC’s pathophysiology is multifaceted, with key factors being immaturity of the immune and barrier protective mechanisms of the premature gut and exaggerated proinflammatory reaction to insults like gut hypoxia, enteral nutrition or microbial dysbiosis. The role of the intestinal microbiome in the pathophysiology of NEC has been a subject of research for many years, but to date no specific pathogen or type of dysbiosis has been connected with NEC development. This review assesses current knowledge as to the role of the intestinal microbiota in the pathophysiology of NEC and the possibilities for positively influencing it |
| first_indexed | 2024-03-08T18:14:21Z |
| format | Article |
| id | doaj.art-19afc9e5d2d5415e81adfaeb09412495 |
| institution | Directory Open Access Journal |
| issn | 2399-9772 |
| language | English |
| last_indexed | 2024-03-08T18:14:21Z |
| publishDate | 2023-12-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Paediatrics Open |
| spelling | doaj.art-19afc9e5d2d5415e81adfaeb094124952023-12-31T13:00:08ZengBMJ Publishing GroupBMJ Paediatrics Open2399-97722023-12-017110.1136/bmjpo-2023-002172Role of the microbiome in pathophysiology of necrotising enterocolitis in preterm neonatesOndrej Slaby0Andrea Stanikova1Martin Jouza2Julia Bohosova3Petr Jabandziev4Central European Institute of Technology, Masaryk University, Brno, Czech RepublicDepartment of Neonatology, University Hospital Brno, Brno, Czech RepublicFaculty of Medicine, Masaryk University, Brno, Czech RepublicCentral European Institute of Technology, Masaryk University, Brno, Czech RepublicFaculty of Medicine, Masaryk University, Brno, Czech RepublicAlthough necrotising enterocolitis (NEC) is a serious, life-threatening disease, improved neonatal care is increasing the number of survivors with NEC among extremely preterm neonates. Therapy is nevertheless mostly symptomatic and the mortality rate remains high, especially among neonates requiring surgery. Therefore, it is important to focus on preventing the disease and modifiable risk factors. NEC’s pathophysiology is multifaceted, with key factors being immaturity of the immune and barrier protective mechanisms of the premature gut and exaggerated proinflammatory reaction to insults like gut hypoxia, enteral nutrition or microbial dysbiosis. The role of the intestinal microbiome in the pathophysiology of NEC has been a subject of research for many years, but to date no specific pathogen or type of dysbiosis has been connected with NEC development. This review assesses current knowledge as to the role of the intestinal microbiota in the pathophysiology of NEC and the possibilities for positively influencing ithttps://bmjpaedsopen.bmj.com/content/7/1/e002172.full |
| spellingShingle | Ondrej Slaby Andrea Stanikova Martin Jouza Julia Bohosova Petr Jabandziev Role of the microbiome in pathophysiology of necrotising enterocolitis in preterm neonates BMJ Paediatrics Open |
| title | Role of the microbiome in pathophysiology of necrotising enterocolitis in preterm neonates |
| title_full | Role of the microbiome in pathophysiology of necrotising enterocolitis in preterm neonates |
| title_fullStr | Role of the microbiome in pathophysiology of necrotising enterocolitis in preterm neonates |
| title_full_unstemmed | Role of the microbiome in pathophysiology of necrotising enterocolitis in preterm neonates |
| title_short | Role of the microbiome in pathophysiology of necrotising enterocolitis in preterm neonates |
| title_sort | role of the microbiome in pathophysiology of necrotising enterocolitis in preterm neonates |
| url | https://bmjpaedsopen.bmj.com/content/7/1/e002172.full |
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