Localized periodontitis and kidney function for the risk of proteinuria in young adults in the CHIEF oral health study
Abstract This study aimed to investigate the association of localized periodontitis with proteinuria in 1281 military young adults in Taiwan. Localized periodontitis was classified as Healthy/Stage I (N = 928) or Stage II/III (N = 353). Stage 2 chronic kidney disease (CKD) was defined as an estimate...
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Nature Portfolio
2022-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-23843-0 |
| _version_ | 1817970504912338944 |
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| author | Kun-Zhe Tsai Pang-Yen Liu Tsung-Jui Wu Chia-Hao Fan Wan-Chien Cheng Ren-Yeong Huang Gen-Min Lin |
| author_facet | Kun-Zhe Tsai Pang-Yen Liu Tsung-Jui Wu Chia-Hao Fan Wan-Chien Cheng Ren-Yeong Huang Gen-Min Lin |
| author_sort | Kun-Zhe Tsai |
| collection | DOAJ |
| description | Abstract This study aimed to investigate the association of localized periodontitis with proteinuria in 1281 military young adults in Taiwan. Localized periodontitis was classified as Healthy/Stage I (N = 928) or Stage II/III (N = 353). Stage 2 chronic kidney disease (CKD) was defined as an estimated glomerular filtration rate (eGFR) of 60–89 mL/min/1.73 m2. Proteinuria was defined as protein levels of 2+ or 3+ on the dipstick test. Multiple logistic regression analysis with adjustments for age, sex, body mass index, remaining teeth number and other potential covariates were used to determine the association between localized Stage II/III periodontitis and dipstick proteinuria in patients with and without CKD. Localized stage II/III periodontitis was associated with a higher risk of dipstick proteinuria [odds ratio (OR) and 95% confidence interval: 1.89 (1.04–3.42)], but not with stage 2 CKD. However, the association between localized stage II/III periodontitis and dipstick proteinuria was observed only in patients with stage 2 CKD [OR: 3.80 (1.56–9.27)], while the association was null in participants without stage 2 CKD [OR: 1.02 (0.42–2.45)]. Our findings suggest that among young adults, especially those with a mildly impaired eGFR, localized periodontitis might contribute to acute or chronic kidney injury, which manifests as proteinuria. |
| first_indexed | 2024-04-13T20:35:00Z |
| format | Article |
| id | doaj.art-19b0314116df4a67b40085fb83d41307 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-13T20:35:00Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-19b0314116df4a67b40085fb83d413072022-12-22T02:31:03ZengNature PortfolioScientific Reports2045-23222022-11-011211610.1038/s41598-022-23843-0Localized periodontitis and kidney function for the risk of proteinuria in young adults in the CHIEF oral health studyKun-Zhe Tsai0Pang-Yen Liu1Tsung-Jui Wu2Chia-Hao Fan3Wan-Chien Cheng4Ren-Yeong Huang5Gen-Min Lin6Department of Medicine, Hualien Armed Forces General HospitalDepartment of Internal Medicine, National Defense Medical Center, Tri-Service General HospitalDepartment of Medicine, Hualien Armed Forces General HospitalDepartment of Medicine, Hualien Armed Forces General HospitalDepartments of Dentistry, National Defense Medical Center, Tri-Service General HospitalDepartments of Dentistry, National Defense Medical Center, Tri-Service General HospitalDepartment of Medicine, Hualien Armed Forces General HospitalAbstract This study aimed to investigate the association of localized periodontitis with proteinuria in 1281 military young adults in Taiwan. Localized periodontitis was classified as Healthy/Stage I (N = 928) or Stage II/III (N = 353). Stage 2 chronic kidney disease (CKD) was defined as an estimated glomerular filtration rate (eGFR) of 60–89 mL/min/1.73 m2. Proteinuria was defined as protein levels of 2+ or 3+ on the dipstick test. Multiple logistic regression analysis with adjustments for age, sex, body mass index, remaining teeth number and other potential covariates were used to determine the association between localized Stage II/III periodontitis and dipstick proteinuria in patients with and without CKD. Localized stage II/III periodontitis was associated with a higher risk of dipstick proteinuria [odds ratio (OR) and 95% confidence interval: 1.89 (1.04–3.42)], but not with stage 2 CKD. However, the association between localized stage II/III periodontitis and dipstick proteinuria was observed only in patients with stage 2 CKD [OR: 3.80 (1.56–9.27)], while the association was null in participants without stage 2 CKD [OR: 1.02 (0.42–2.45)]. Our findings suggest that among young adults, especially those with a mildly impaired eGFR, localized periodontitis might contribute to acute or chronic kidney injury, which manifests as proteinuria.https://doi.org/10.1038/s41598-022-23843-0 |
| spellingShingle | Kun-Zhe Tsai Pang-Yen Liu Tsung-Jui Wu Chia-Hao Fan Wan-Chien Cheng Ren-Yeong Huang Gen-Min Lin Localized periodontitis and kidney function for the risk of proteinuria in young adults in the CHIEF oral health study Scientific Reports |
| title | Localized periodontitis and kidney function for the risk of proteinuria in young adults in the CHIEF oral health study |
| title_full | Localized periodontitis and kidney function for the risk of proteinuria in young adults in the CHIEF oral health study |
| title_fullStr | Localized periodontitis and kidney function for the risk of proteinuria in young adults in the CHIEF oral health study |
| title_full_unstemmed | Localized periodontitis and kidney function for the risk of proteinuria in young adults in the CHIEF oral health study |
| title_short | Localized periodontitis and kidney function for the risk of proteinuria in young adults in the CHIEF oral health study |
| title_sort | localized periodontitis and kidney function for the risk of proteinuria in young adults in the chief oral health study |
| url | https://doi.org/10.1038/s41598-022-23843-0 |
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