Nanoliposomes from Agro-Resources as Promising Delivery Systems for Chondrocytes
Investigations in cartilage biology have been hampered by the limited capacity of chondrocytes, especially in rats and humans, to be efficiently transfected. Liposomes are a promising delivery system due to their lipid bilayer structure similar to a biological membrane. Here we used natural rapeseed...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/10/3436 |
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| author | Arnaud Bianchi Émilie Velot Hervé Kempf Kamil Elkhoury Laura Sanchez-Gonzalez Michel Linder Cyril Kahn Elmira Arab-Tehrany |
| author_facet | Arnaud Bianchi Émilie Velot Hervé Kempf Kamil Elkhoury Laura Sanchez-Gonzalez Michel Linder Cyril Kahn Elmira Arab-Tehrany |
| author_sort | Arnaud Bianchi |
| collection | DOAJ |
| description | Investigations in cartilage biology have been hampered by the limited capacity of chondrocytes, especially in rats and humans, to be efficiently transfected. Liposomes are a promising delivery system due to their lipid bilayer structure similar to a biological membrane. Here we used natural rapeseed lecithin, which contains a high level of mono- and poly-unsaturated fatty acids, to evaluate the cytocompatibility of these phospholipids as future potential carriers of biomolecules in joint regenerative medicine. Results show that appropriate concentrations of nanoliposome rapeseed lecithin under 500 µg/mL were safe for chondrocytes and did not induce any alterations of their phenotype. Altogether, these results sustain that they could represent a novel natural carrier to deliver active substances into cartilage cells. |
| first_indexed | 2024-03-10T19:52:16Z |
| format | Article |
| id | doaj.art-19b0a28e45d7489a914ee0f95beb8291 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T19:52:16Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-19b0a28e45d7489a914ee0f95beb82912023-11-20T00:17:13ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-05-012110343610.3390/ijms21103436Nanoliposomes from Agro-Resources as Promising Delivery Systems for ChondrocytesArnaud Bianchi0Émilie Velot1Hervé Kempf2Kamil Elkhoury3Laura Sanchez-Gonzalez4Michel Linder5Cyril Kahn6Elmira Arab-Tehrany7Faculté de Médecine, Biopôle de l’Université de Lorraine, Campus Brabois-Santé, Laboratoire UMR 7365 CNRS-Université de Lorraine, Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), Université de Lorraine, F-54505 Vandœuvre-Lès-Nancy, FranceFaculté de Médecine, Biopôle de l’Université de Lorraine, Campus Brabois-Santé, Laboratoire UMR 7365 CNRS-Université de Lorraine, Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), Université de Lorraine, F-54505 Vandœuvre-Lès-Nancy, FranceFaculté de Médecine, Biopôle de l’Université de Lorraine, Campus Brabois-Santé, Laboratoire UMR 7365 CNRS-Université de Lorraine, Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), Université de Lorraine, F-54505 Vandœuvre-Lès-Nancy, FranceLaboratoire d’ingénierie des Biomolécules, Université de Lorraine, F-54505 Vandœuvre-Lès-Nancy, FranceLaboratoire d’ingénierie des Biomolécules, Université de Lorraine, F-54505 Vandœuvre-Lès-Nancy, FranceLaboratoire d’ingénierie des Biomolécules, Université de Lorraine, F-54505 Vandœuvre-Lès-Nancy, FranceLaboratoire d’ingénierie des Biomolécules, Université de Lorraine, F-54505 Vandœuvre-Lès-Nancy, FranceLaboratoire d’ingénierie des Biomolécules, Université de Lorraine, F-54505 Vandœuvre-Lès-Nancy, FranceInvestigations in cartilage biology have been hampered by the limited capacity of chondrocytes, especially in rats and humans, to be efficiently transfected. Liposomes are a promising delivery system due to their lipid bilayer structure similar to a biological membrane. Here we used natural rapeseed lecithin, which contains a high level of mono- and poly-unsaturated fatty acids, to evaluate the cytocompatibility of these phospholipids as future potential carriers of biomolecules in joint regenerative medicine. Results show that appropriate concentrations of nanoliposome rapeseed lecithin under 500 µg/mL were safe for chondrocytes and did not induce any alterations of their phenotype. Altogether, these results sustain that they could represent a novel natural carrier to deliver active substances into cartilage cells.https://www.mdpi.com/1422-0067/21/10/3436liposomeschondrocytePUFAdrug delivery systemjoint regenerative medicine |
| spellingShingle | Arnaud Bianchi Émilie Velot Hervé Kempf Kamil Elkhoury Laura Sanchez-Gonzalez Michel Linder Cyril Kahn Elmira Arab-Tehrany Nanoliposomes from Agro-Resources as Promising Delivery Systems for Chondrocytes International Journal of Molecular Sciences liposomes chondrocyte PUFA drug delivery system joint regenerative medicine |
| title | Nanoliposomes from Agro-Resources as Promising Delivery Systems for Chondrocytes |
| title_full | Nanoliposomes from Agro-Resources as Promising Delivery Systems for Chondrocytes |
| title_fullStr | Nanoliposomes from Agro-Resources as Promising Delivery Systems for Chondrocytes |
| title_full_unstemmed | Nanoliposomes from Agro-Resources as Promising Delivery Systems for Chondrocytes |
| title_short | Nanoliposomes from Agro-Resources as Promising Delivery Systems for Chondrocytes |
| title_sort | nanoliposomes from agro resources as promising delivery systems for chondrocytes |
| topic | liposomes chondrocyte PUFA drug delivery system joint regenerative medicine |
| url | https://www.mdpi.com/1422-0067/21/10/3436 |
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