Usefulness of semi-automatic harmonization strategy of standardized uptake values for multicenter PET studies
Abstract This study assessed the possibility of semi-automatic harmonization of standardized uptake values (SUVs) in multicenter studies. Phantom data were acquired using 16 PET/CT scanners (including 3 PET/CT scanners with a silicon photomultiplier detector). PET images obtained using 30-min/bed sc...
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| Format: | Article |
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Nature Portfolio
2021-04-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-87942-0 |
| _version_ | 1830296981592866816 |
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| author | Hiromitsu Daisaki Kazuhiro Kitajima Masatoyo Nakajo Tadashi Watabe Kimiteru Ito Fumi Sakamoto Tadaki Nakahara Mana Ishibashi Akira Toriihara |
| author_facet | Hiromitsu Daisaki Kazuhiro Kitajima Masatoyo Nakajo Tadashi Watabe Kimiteru Ito Fumi Sakamoto Tadaki Nakahara Mana Ishibashi Akira Toriihara |
| author_sort | Hiromitsu Daisaki |
| collection | DOAJ |
| description | Abstract This study assessed the possibility of semi-automatic harmonization of standardized uptake values (SUVs) in multicenter studies. Phantom data were acquired using 16 PET/CT scanners (including 3 PET/CT scanners with a silicon photomultiplier detector). PET images obtained using 30-min/bed scans for optimum harmonization filter calculations and using 90–180-s/bed scans for SUV validation under clinical conditions were obtained. Time of flight and a reconstruction method with point-spread function correction were allowed. The optimal full width at half maximum of the 3D-Gaussian filter that minimizes the root mean square error with the median value of the JSNM harmonization range was calculated semi-automatically. The SUVmax and the SUVpeak of the hot spheres were measured, and the inter-scanner coefficient of variation (COV) was calculated before and after harmonization. The harmonization filter was applied to 11 of the 15 PET/CT scanners in which the SUV calibration accuracy had been verified, but not in the remaining 4 scanners. Under noiseless conditions before harmonization, the inter-scanner COVs of the SUVmax and the SUVpeak were as high as 21.57% and 12.20%, respectively, decreasing to 8.79% and 5.73% after harmonization, respectively. Harmonization brought the SUVmax of all the hot spheres to within the harmonization range. Even under clinical conditions affected by image noise, the inter-scanner COVs for the SUVmax and SUVpeak were as high as 8.83% and 5.18% after harmonization, respectively. By applying an optimal harmonization filter that is calculated semi-automatically, the harmonization of SUVs according to the JSNM strategy is possible in multicenter studies, thereby reducing inter-scanner COVs. |
| first_indexed | 2024-12-19T07:25:16Z |
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| id | doaj.art-19b1de834b034dc791e419a48eca77e7 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-19T07:25:16Z |
| publishDate | 2021-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-19b1de834b034dc791e419a48eca77e72022-12-21T20:30:50ZengNature PortfolioScientific Reports2045-23222021-04-0111111210.1038/s41598-021-87942-0Usefulness of semi-automatic harmonization strategy of standardized uptake values for multicenter PET studiesHiromitsu Daisaki0Kazuhiro Kitajima1Masatoyo Nakajo2Tadashi Watabe3Kimiteru Ito4Fumi Sakamoto5Tadaki Nakahara6Mana Ishibashi7Akira Toriihara8Graduate School of Radiological Technology, Gunma Prefectural College of Health ScienceDivision of Nuclear Medicine and PET Center, Department of Radiology, Hyogo College of MedicineDepartment of Radiology, Graduate School of Medical and Dental Sciences, Kagoshima UniversityDepartment of Nuclear Medicine and Tracer Kinetics, Graduate School of Medicine, Osaka UniversityDepartment of Diagnostic Radiology, National Cancer Center HospitalDepartment of Diagnostic Radiology, Graduate School of Life Sciences, Kumamoto UniversityDepartment of Diagnostic Radiology, Keio University School of MedicineDivision of Radiology, Department of Pathophysiological and Therapeutic Sciences, Tottori UniversityPET Imaging Center, Asahi General HospitalAbstract This study assessed the possibility of semi-automatic harmonization of standardized uptake values (SUVs) in multicenter studies. Phantom data were acquired using 16 PET/CT scanners (including 3 PET/CT scanners with a silicon photomultiplier detector). PET images obtained using 30-min/bed scans for optimum harmonization filter calculations and using 90–180-s/bed scans for SUV validation under clinical conditions were obtained. Time of flight and a reconstruction method with point-spread function correction were allowed. The optimal full width at half maximum of the 3D-Gaussian filter that minimizes the root mean square error with the median value of the JSNM harmonization range was calculated semi-automatically. The SUVmax and the SUVpeak of the hot spheres were measured, and the inter-scanner coefficient of variation (COV) was calculated before and after harmonization. The harmonization filter was applied to 11 of the 15 PET/CT scanners in which the SUV calibration accuracy had been verified, but not in the remaining 4 scanners. Under noiseless conditions before harmonization, the inter-scanner COVs of the SUVmax and the SUVpeak were as high as 21.57% and 12.20%, respectively, decreasing to 8.79% and 5.73% after harmonization, respectively. Harmonization brought the SUVmax of all the hot spheres to within the harmonization range. Even under clinical conditions affected by image noise, the inter-scanner COVs for the SUVmax and SUVpeak were as high as 8.83% and 5.18% after harmonization, respectively. By applying an optimal harmonization filter that is calculated semi-automatically, the harmonization of SUVs according to the JSNM strategy is possible in multicenter studies, thereby reducing inter-scanner COVs.https://doi.org/10.1038/s41598-021-87942-0 |
| spellingShingle | Hiromitsu Daisaki Kazuhiro Kitajima Masatoyo Nakajo Tadashi Watabe Kimiteru Ito Fumi Sakamoto Tadaki Nakahara Mana Ishibashi Akira Toriihara Usefulness of semi-automatic harmonization strategy of standardized uptake values for multicenter PET studies Scientific Reports |
| title | Usefulness of semi-automatic harmonization strategy of standardized uptake values for multicenter PET studies |
| title_full | Usefulness of semi-automatic harmonization strategy of standardized uptake values for multicenter PET studies |
| title_fullStr | Usefulness of semi-automatic harmonization strategy of standardized uptake values for multicenter PET studies |
| title_full_unstemmed | Usefulness of semi-automatic harmonization strategy of standardized uptake values for multicenter PET studies |
| title_short | Usefulness of semi-automatic harmonization strategy of standardized uptake values for multicenter PET studies |
| title_sort | usefulness of semi automatic harmonization strategy of standardized uptake values for multicenter pet studies |
| url | https://doi.org/10.1038/s41598-021-87942-0 |
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