Preoperative Platelet-Lymphocyte Ratio (PLR) as a prognostic inflammation biomarker in Asian HIV-infected patients with gastric cancer: a single-center study
Abstract Background The serum systemic inflammation biomarkers have been established as predictors of prognosis in gastric cancer (GC) patients, but their prognostic value in human immunodeficiency virus (HIV)-infected patients with GC has not been well studied. This retrospective study aimed to eva...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-05-01
|
| Series: | BMC Gastroenterology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12876-023-02828-x |
| _version_ | 1797817963846303744 |
|---|---|
| author | Li Deng Lei Li Yiling Qiu Ye Cao Shixian Lian Yanhui Si |
| author_facet | Li Deng Lei Li Yiling Qiu Ye Cao Shixian Lian Yanhui Si |
| author_sort | Li Deng |
| collection | DOAJ |
| description | Abstract Background The serum systemic inflammation biomarkers have been established as predictors of prognosis in gastric cancer (GC) patients, but their prognostic value in human immunodeficiency virus (HIV)-infected patients with GC has not been well studied. This retrospective study aimed to evaluate the prognostic value of preoperative systemic inflammation biomarkers in Asian HIV-infected patients with GC. Methods We retrospectively analyzed 41 HIV-infected GC patients who underwent surgery between January 2015 and December 2021 at the Shanghai Public Health Clinical Center. Preoperative systemic inflammation biomarkers were measured and patients were divided into two groups based on the optimal cut-off value. Overall survival (OS) and progression-free survival (PFS) were measured using the Kaplan–Meier method and the log-rank test. Multivariate analysis of variables was performed using the Cox proportional regression model. As a comparison, 127 GC patients without HIV infection were also recruited. Results The median age of the 41 patients included in the study was 59 years, with 39 males and two females. The follow-up period for OS and PFS ranged from 3 to 94 months. The cumulative three-year OS rate was 46.0%, and the cumulative three-year PFS rate was 44%. HIV-infected GC patients had worse clinical outcomes compared to the normal GC population. The optimal cut-off value for preoperative platelet to lymphocyte ratio (PLR) was 199 in HIV-infected GC patients. Multivariate Cox regression analysis revealed that a low PLR was an independent predictor of better OS and PFS (OS: HR = 0.038, 95% CI: 0.006–0.258, P < 0.001; PFS: HR = 0.027, 95% CI: 0.004–0.201, P < 0.001). Furthermore, higher preoperative PLR in HIV-infected GC was significantly associated with lower BMI, hemoglobin, albumin, CD4 + T, CD8 + T, and CD3 + T cell counts. Conclusion The preoperative PLR is an easily measurable immune biomarker that may provide useful prognostic information in HIV-infected GC patients. Our findings suggest that PLR could be a valuable clinical tool for guiding treatment decisions in this population. |
| first_indexed | 2024-03-13T09:01:12Z |
| format | Article |
| id | doaj.art-19b3e243f4324d8d936af7bd341f7289 |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-03-13T09:01:12Z |
| publishDate | 2023-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-19b3e243f4324d8d936af7bd341f72892023-05-28T11:18:25ZengBMCBMC Gastroenterology1471-230X2023-05-0123111210.1186/s12876-023-02828-xPreoperative Platelet-Lymphocyte Ratio (PLR) as a prognostic inflammation biomarker in Asian HIV-infected patients with gastric cancer: a single-center studyLi Deng0Lei Li1Yiling Qiu2Ye Cao3Shixian Lian4Yanhui Si5Department of General Surgery, Shanghai Public Health Clinical Center, Fudan UniversityDepartment of General Surgery, Shanghai Public Health Clinical Center, Fudan UniversityDepartment of Infectious Diseases, Children’s Hospital of Fudan UniversityDepartment of General Surgery, Shanghai Public Health Clinical Center, Fudan UniversityDepartment of General Surgery, Shanghai Public Health Clinical Center, Fudan UniversityDepartment of General Surgery, Shanghai Public Health Clinical Center, Fudan UniversityAbstract Background The serum systemic inflammation biomarkers have been established as predictors of prognosis in gastric cancer (GC) patients, but their prognostic value in human immunodeficiency virus (HIV)-infected patients with GC has not been well studied. This retrospective study aimed to evaluate the prognostic value of preoperative systemic inflammation biomarkers in Asian HIV-infected patients with GC. Methods We retrospectively analyzed 41 HIV-infected GC patients who underwent surgery between January 2015 and December 2021 at the Shanghai Public Health Clinical Center. Preoperative systemic inflammation biomarkers were measured and patients were divided into two groups based on the optimal cut-off value. Overall survival (OS) and progression-free survival (PFS) were measured using the Kaplan–Meier method and the log-rank test. Multivariate analysis of variables was performed using the Cox proportional regression model. As a comparison, 127 GC patients without HIV infection were also recruited. Results The median age of the 41 patients included in the study was 59 years, with 39 males and two females. The follow-up period for OS and PFS ranged from 3 to 94 months. The cumulative three-year OS rate was 46.0%, and the cumulative three-year PFS rate was 44%. HIV-infected GC patients had worse clinical outcomes compared to the normal GC population. The optimal cut-off value for preoperative platelet to lymphocyte ratio (PLR) was 199 in HIV-infected GC patients. Multivariate Cox regression analysis revealed that a low PLR was an independent predictor of better OS and PFS (OS: HR = 0.038, 95% CI: 0.006–0.258, P < 0.001; PFS: HR = 0.027, 95% CI: 0.004–0.201, P < 0.001). Furthermore, higher preoperative PLR in HIV-infected GC was significantly associated with lower BMI, hemoglobin, albumin, CD4 + T, CD8 + T, and CD3 + T cell counts. Conclusion The preoperative PLR is an easily measurable immune biomarker that may provide useful prognostic information in HIV-infected GC patients. Our findings suggest that PLR could be a valuable clinical tool for guiding treatment decisions in this population.https://doi.org/10.1186/s12876-023-02828-xHIVGastric cancerSystemic inflammation biomarkerPlatelet to lymphocyte ratioPrognosis |
| spellingShingle | Li Deng Lei Li Yiling Qiu Ye Cao Shixian Lian Yanhui Si Preoperative Platelet-Lymphocyte Ratio (PLR) as a prognostic inflammation biomarker in Asian HIV-infected patients with gastric cancer: a single-center study BMC Gastroenterology HIV Gastric cancer Systemic inflammation biomarker Platelet to lymphocyte ratio Prognosis |
| title | Preoperative Platelet-Lymphocyte Ratio (PLR) as a prognostic inflammation biomarker in Asian HIV-infected patients with gastric cancer: a single-center study |
| title_full | Preoperative Platelet-Lymphocyte Ratio (PLR) as a prognostic inflammation biomarker in Asian HIV-infected patients with gastric cancer: a single-center study |
| title_fullStr | Preoperative Platelet-Lymphocyte Ratio (PLR) as a prognostic inflammation biomarker in Asian HIV-infected patients with gastric cancer: a single-center study |
| title_full_unstemmed | Preoperative Platelet-Lymphocyte Ratio (PLR) as a prognostic inflammation biomarker in Asian HIV-infected patients with gastric cancer: a single-center study |
| title_short | Preoperative Platelet-Lymphocyte Ratio (PLR) as a prognostic inflammation biomarker in Asian HIV-infected patients with gastric cancer: a single-center study |
| title_sort | preoperative platelet lymphocyte ratio plr as a prognostic inflammation biomarker in asian hiv infected patients with gastric cancer a single center study |
| topic | HIV Gastric cancer Systemic inflammation biomarker Platelet to lymphocyte ratio Prognosis |
| url | https://doi.org/10.1186/s12876-023-02828-x |
| work_keys_str_mv | AT lideng preoperativeplateletlymphocyteratioplrasaprognosticinflammationbiomarkerinasianhivinfectedpatientswithgastriccancerasinglecenterstudy AT leili preoperativeplateletlymphocyteratioplrasaprognosticinflammationbiomarkerinasianhivinfectedpatientswithgastriccancerasinglecenterstudy AT yilingqiu preoperativeplateletlymphocyteratioplrasaprognosticinflammationbiomarkerinasianhivinfectedpatientswithgastriccancerasinglecenterstudy AT yecao preoperativeplateletlymphocyteratioplrasaprognosticinflammationbiomarkerinasianhivinfectedpatientswithgastriccancerasinglecenterstudy AT shixianlian preoperativeplateletlymphocyteratioplrasaprognosticinflammationbiomarkerinasianhivinfectedpatientswithgastriccancerasinglecenterstudy AT yanhuisi preoperativeplateletlymphocyteratioplrasaprognosticinflammationbiomarkerinasianhivinfectedpatientswithgastriccancerasinglecenterstudy |