Identification of Biological Pathways Contributing to Marbling in Skeletal Muscle to Improve Beef Cattle Breeding
Red meat is an important dietary source that provides part of the nutritional requirements. Intramuscular fat, known as marbling, is located throughout skeletal muscle. Marbling is a trait of major economic relevance that positively influences sensory quality aspects. The aim of the present study wa...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-02-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fgene.2019.01370/full |
| _version_ | 1819144320307953664 |
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| author | Zahra Roudbari Zahra Roudbari Susan L. Coort Martina Kutmon Martina Kutmon Lars Eijssen Jonathan Melius Tomasz Sadkowski Chris T. Evelo Chris T. Evelo |
| author_facet | Zahra Roudbari Zahra Roudbari Susan L. Coort Martina Kutmon Martina Kutmon Lars Eijssen Jonathan Melius Tomasz Sadkowski Chris T. Evelo Chris T. Evelo |
| author_sort | Zahra Roudbari |
| collection | DOAJ |
| description | Red meat is an important dietary source that provides part of the nutritional requirements. Intramuscular fat, known as marbling, is located throughout skeletal muscle. Marbling is a trait of major economic relevance that positively influences sensory quality aspects. The aim of the present study was to identify and better understand biological pathways defining marbling in beef cattle. Pathway analysis was performed in PathVisio with publicly available transcriptomic data from semitendinosus muscle of well-marbled and lean-marbled beef. Moreover, for Bos taurus we created a gene identifier mapping database with bridgeDb and a pathway collection in WikiPathways. The regulation of marbling is possibly the result of the interplay between signaling pathways in muscle, fat, and intramuscular connective tissue. Pathway analysis revealed 17 pathways that were significantly different between well-marbled and lean-marbled beef. The MAPK signaling pathway was enriched, and the signaling pathways that play a role in tissue development were also affected. Interestingly, pathways related to immune response and insulin signaling were enriched. |
| first_indexed | 2024-12-22T12:40:16Z |
| format | Article |
| id | doaj.art-19b3f1cad06544d29ecbc4b41133dbef |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-22T12:40:16Z |
| publishDate | 2020-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-19b3f1cad06544d29ecbc4b41133dbef2022-12-21T18:25:28ZengFrontiers Media S.A.Frontiers in Genetics1664-80212020-02-011010.3389/fgene.2019.01370495856Identification of Biological Pathways Contributing to Marbling in Skeletal Muscle to Improve Beef Cattle BreedingZahra Roudbari0Zahra Roudbari1Susan L. Coort2Martina Kutmon3Martina Kutmon4Lars Eijssen5Jonathan Melius6Tomasz Sadkowski7Chris T. Evelo8Chris T. Evelo9Department of Animal Science, Faculty of Agriculture, University of Jiroft, Jiroft, IranDepartment of Bioinformatics-BiGCaT, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, NetherlandsDepartment of Bioinformatics-BiGCaT, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, NetherlandsDepartment of Bioinformatics-BiGCaT, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, NetherlandsMaastricht Centre for Systems Biology (MaCSBio), Maastricht University, Maastricht, NetherlandsDepartment of Bioinformatics-BiGCaT, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, NetherlandsDepartment of Bioinformatics-BiGCaT, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, NetherlandsDepartment of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences - SGGW, Warsaw, PolandDepartment of Bioinformatics-BiGCaT, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, NetherlandsMaastricht Centre for Systems Biology (MaCSBio), Maastricht University, Maastricht, NetherlandsRed meat is an important dietary source that provides part of the nutritional requirements. Intramuscular fat, known as marbling, is located throughout skeletal muscle. Marbling is a trait of major economic relevance that positively influences sensory quality aspects. The aim of the present study was to identify and better understand biological pathways defining marbling in beef cattle. Pathway analysis was performed in PathVisio with publicly available transcriptomic data from semitendinosus muscle of well-marbled and lean-marbled beef. Moreover, for Bos taurus we created a gene identifier mapping database with bridgeDb and a pathway collection in WikiPathways. The regulation of marbling is possibly the result of the interplay between signaling pathways in muscle, fat, and intramuscular connective tissue. Pathway analysis revealed 17 pathways that were significantly different between well-marbled and lean-marbled beef. The MAPK signaling pathway was enriched, and the signaling pathways that play a role in tissue development were also affected. Interestingly, pathways related to immune response and insulin signaling were enriched.https://www.frontiersin.org/article/10.3389/fgene.2019.01370/fullmarblingcuration pathway for cowsignaling pathwayimprove breeding selectiontranscriptomics profiling |
| spellingShingle | Zahra Roudbari Zahra Roudbari Susan L. Coort Martina Kutmon Martina Kutmon Lars Eijssen Jonathan Melius Tomasz Sadkowski Chris T. Evelo Chris T. Evelo Identification of Biological Pathways Contributing to Marbling in Skeletal Muscle to Improve Beef Cattle Breeding Frontiers in Genetics marbling curation pathway for cow signaling pathway improve breeding selection transcriptomics profiling |
| title | Identification of Biological Pathways Contributing to Marbling in Skeletal Muscle to Improve Beef Cattle Breeding |
| title_full | Identification of Biological Pathways Contributing to Marbling in Skeletal Muscle to Improve Beef Cattle Breeding |
| title_fullStr | Identification of Biological Pathways Contributing to Marbling in Skeletal Muscle to Improve Beef Cattle Breeding |
| title_full_unstemmed | Identification of Biological Pathways Contributing to Marbling in Skeletal Muscle to Improve Beef Cattle Breeding |
| title_short | Identification of Biological Pathways Contributing to Marbling in Skeletal Muscle to Improve Beef Cattle Breeding |
| title_sort | identification of biological pathways contributing to marbling in skeletal muscle to improve beef cattle breeding |
| topic | marbling curation pathway for cow signaling pathway improve breeding selection transcriptomics profiling |
| url | https://www.frontiersin.org/article/10.3389/fgene.2019.01370/full |
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