A Novel Peptide, Nicotinyl–Isoleucine–Valine–Histidine (NA–IVH), Promotes Antioxidant Gene Expression and Wound Healing in HaCaT Cells
Nicotinamide (NA), a water-soluble vitamin B3, has been shown to exert cellular-protective effects against reactive oxygen species (ROS). In order to improve the cellular-protective effects of NA, we synthesized a novel compound, nicotinyl–isoleucine–valine–histidine (N...
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MDPI AG
2018-08-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/16/8/262 |
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| author | Dong Hwee Son Dong Joo Yang Ji Su Sun Seul Ki Kim Namju Kang Jung Yun Kang Yun-Hee Choi Jeong Hun Lee Sang Hyun Moh Dong Min Shin Ki Woo Kim |
| author_facet | Dong Hwee Son Dong Joo Yang Ji Su Sun Seul Ki Kim Namju Kang Jung Yun Kang Yun-Hee Choi Jeong Hun Lee Sang Hyun Moh Dong Min Shin Ki Woo Kim |
| author_sort | Dong Hwee Son |
| collection | DOAJ |
| description | Nicotinamide (NA), a water-soluble vitamin B3, has been shown to exert cellular-protective effects against reactive oxygen species (ROS). In order to improve the cellular-protective effects of NA, we synthesized a novel compound, nicotinyl–isoleucine–valine–histidine (NA–IVH), by combining NA with jellyfish peptides’ IVH. In the present study, we examined the cellular-protective effects of the novel synthetic nicotinyl-peptide, NA–IVH. We found that NA–IVH enhances the radical scavenging activity with a robust increase of the nuclear factor (erythroid-derived 2)-like factor (Nrf2) expression in human HaCaT keratinocytes. In addition, NA–IVH protected the cells from hydrogen peroxide (H2O2)-induced cell death. Interestingly, NA–IVH exhibited an improved wound-healing effect in a high glucose condition, possibly through the regulation of reactive oxygen species (ROS). Collectively, our results imply that a novel nicotinyl-peptide, NA–IVH, has a wound-healing effect in a hyperglycemic condition, possibly by modulating excessive ROS. |
| first_indexed | 2024-04-11T22:29:55Z |
| format | Article |
| id | doaj.art-19b53245744741f2aeafa16bea9ac6bb |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-11T22:29:55Z |
| publishDate | 2018-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-19b53245744741f2aeafa16bea9ac6bb2022-12-22T03:59:29ZengMDPI AGMarine Drugs1660-33972018-08-0116826210.3390/md16080262md16080262A Novel Peptide, Nicotinyl–Isoleucine–Valine–Histidine (NA–IVH), Promotes Antioxidant Gene Expression and Wound Healing in HaCaT CellsDong Hwee Son0Dong Joo Yang1Ji Su Sun2Seul Ki Kim3Namju Kang4Jung Yun Kang5Yun-Hee Choi6Jeong Hun Lee7Sang Hyun Moh8Dong Min Shin9Ki Woo Kim10Department of Oral Biology, BK21 PLUS, Yonsei University College of Dentistry, Seoul 03722, KoreaDepartment of Oral Biology, BK21 PLUS, Yonsei University College of Dentistry, Seoul 03722, KoreaDepartment of Oral Biology, BK21 PLUS, Yonsei University College of Dentistry, Seoul 03722, KoreaDepartment of Oral Biology, BK21 PLUS, Yonsei University College of Dentistry, Seoul 03722, KoreaDepartment of Oral Biology, BK21 PLUS, Yonsei University College of Dentistry, Seoul 03722, KoreaDepartment of Oral Biology, BK21 PLUS, Yonsei University College of Dentistry, Seoul 03722, KoreaDepartment of Oral Biology, BK21 PLUS, Yonsei University College of Dentistry, Seoul 03722, KoreaAnti-Aging Research Institute of BIO-FD&C Co. Ltd., Incheon 21990, KoreaAnti-Aging Research Institute of BIO-FD&C Co. Ltd., Incheon 21990, KoreaDepartment of Oral Biology, BK21 PLUS, Yonsei University College of Dentistry, Seoul 03722, KoreaDepartment of Oral Biology, BK21 PLUS, Yonsei University College of Dentistry, Seoul 03722, KoreaNicotinamide (NA), a water-soluble vitamin B3, has been shown to exert cellular-protective effects against reactive oxygen species (ROS). In order to improve the cellular-protective effects of NA, we synthesized a novel compound, nicotinyl–isoleucine–valine–histidine (NA–IVH), by combining NA with jellyfish peptides’ IVH. In the present study, we examined the cellular-protective effects of the novel synthetic nicotinyl-peptide, NA–IVH. We found that NA–IVH enhances the radical scavenging activity with a robust increase of the nuclear factor (erythroid-derived 2)-like factor (Nrf2) expression in human HaCaT keratinocytes. In addition, NA–IVH protected the cells from hydrogen peroxide (H2O2)-induced cell death. Interestingly, NA–IVH exhibited an improved wound-healing effect in a high glucose condition, possibly through the regulation of reactive oxygen species (ROS). Collectively, our results imply that a novel nicotinyl-peptide, NA–IVH, has a wound-healing effect in a hyperglycemic condition, possibly by modulating excessive ROS.http://www.mdpi.com/1660-3397/16/8/262nicotinamideisoleucine-valine-histidineantioxidantnuclear factor (erythroid-derived 2)-like factorwound-healing |
| spellingShingle | Dong Hwee Son Dong Joo Yang Ji Su Sun Seul Ki Kim Namju Kang Jung Yun Kang Yun-Hee Choi Jeong Hun Lee Sang Hyun Moh Dong Min Shin Ki Woo Kim A Novel Peptide, Nicotinyl–Isoleucine–Valine–Histidine (NA–IVH), Promotes Antioxidant Gene Expression and Wound Healing in HaCaT Cells Marine Drugs nicotinamide isoleucine-valine-histidine antioxidant nuclear factor (erythroid-derived 2)-like factor wound-healing |
| title | A Novel Peptide, Nicotinyl–Isoleucine–Valine–Histidine (NA–IVH), Promotes Antioxidant Gene Expression and Wound Healing in HaCaT Cells |
| title_full | A Novel Peptide, Nicotinyl–Isoleucine–Valine–Histidine (NA–IVH), Promotes Antioxidant Gene Expression and Wound Healing in HaCaT Cells |
| title_fullStr | A Novel Peptide, Nicotinyl–Isoleucine–Valine–Histidine (NA–IVH), Promotes Antioxidant Gene Expression and Wound Healing in HaCaT Cells |
| title_full_unstemmed | A Novel Peptide, Nicotinyl–Isoleucine–Valine–Histidine (NA–IVH), Promotes Antioxidant Gene Expression and Wound Healing in HaCaT Cells |
| title_short | A Novel Peptide, Nicotinyl–Isoleucine–Valine–Histidine (NA–IVH), Promotes Antioxidant Gene Expression and Wound Healing in HaCaT Cells |
| title_sort | novel peptide nicotinyl isoleucine valine histidine na ivh promotes antioxidant gene expression and wound healing in hacat cells |
| topic | nicotinamide isoleucine-valine-histidine antioxidant nuclear factor (erythroid-derived 2)-like factor wound-healing |
| url | http://www.mdpi.com/1660-3397/16/8/262 |
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