Influence of repeated estrus synchronization treatment on hormone secretion, growth, and development of dairy goats
In large-scale intensive farms, dairy goats often undergo frequent estrus synchronization (ES) treatment, which may result in a decline in reproductive performance; however, the underlying mechanism remains unclear. The present study aimed to investigate the effect of pregnant mare serum gonadotropi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2023.1333633/full |
| _version_ | 1827385764520919040 |
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| author | Shuang Sun Ming Lv Huimin Niu Jun Luo |
| author_facet | Shuang Sun Ming Lv Huimin Niu Jun Luo |
| author_sort | Shuang Sun |
| collection | DOAJ |
| description | In large-scale intensive farms, dairy goats often undergo frequent estrus synchronization (ES) treatment, which may result in a decline in reproductive performance; however, the underlying mechanism remains unclear. The present study aimed to investigate the effect of pregnant mare serum gonadotropin (PMSG) and progesterone (P4)-mediated ES treatment on fertility in dairy goats, while also identifying key metabolic and endocrine mechanisms that influence reproductive performance in does subjected to repeated ES treatment. Forty-eight Saanen does were randomly assigned to two groups (24 goats each) that received ES treatments either thrice fortnightly (3-PMSG) or once (1-PMSG) simultaneously with the third ES treatment of the 3-PMSG group during the breeding season. ES treatment was performed via the intravaginal insertion of a controlled internal drug release (CIDR) device impregnated with 300 mg P4, followed by 300 IU PMSG injections 48 h before CIDR withdrawal. Blood was collected to detect the level of hormones and blood biochemical indices. Additionally, estrus rate, fecundity rate, body weight, size, and lactation performance were measured. The results showed that repeated ES treatment markedly decreased the estrus rate and fecundity rate of goats. Among the does in all groups, there was no substantial difference in follicle stimulating hormone, luteinising hormone, gonadotropin-releasing hormone, melatonin, growth hormone, PMSG, total cholesterol, total protein, and glucose levels, as well as the body weight, body size, and lactation performance. Repeated ES treatment elevated estrogen (E2) levels 36, 48, and 72 h post-CIDR removal; increased P4 upon CIDR insertion; and raised PMSG antibody levels 24, 48, and 72 h post-CIDR removal. The results suggest that elevated anti-PMSG levels are the primary reason for the decline in ES efficiency, and that high E2 and P4 levels at some time points also impair reproductive performance. These findings provide novel insights into the metabolic effects of repeated PMSG stimulation in goats, guiding future reproductive hormone use in breeding practices. |
| first_indexed | 2024-03-08T15:31:19Z |
| format | Article |
| id | doaj.art-19b7b28de16540a981ef179d72f53e2e |
| institution | Directory Open Access Journal |
| issn | 2297-1769 |
| language | English |
| last_indexed | 2024-03-08T15:31:19Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj.art-19b7b28de16540a981ef179d72f53e2e2024-01-10T04:30:32ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692024-01-011010.3389/fvets.2023.13336331333633Influence of repeated estrus synchronization treatment on hormone secretion, growth, and development of dairy goatsShuang Sun0Ming Lv1Huimin Niu2Jun Luo3College of Life Science and Agricultural Engineering, Nanyang Normal University, Nanyang, Henan, ChinaShaanxi Key Laboratory of Molecular Biology for Agriculture, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, ChinaShaanxi Key Laboratory of Molecular Biology for Agriculture, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, ChinaShaanxi Key Laboratory of Molecular Biology for Agriculture, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, ChinaIn large-scale intensive farms, dairy goats often undergo frequent estrus synchronization (ES) treatment, which may result in a decline in reproductive performance; however, the underlying mechanism remains unclear. The present study aimed to investigate the effect of pregnant mare serum gonadotropin (PMSG) and progesterone (P4)-mediated ES treatment on fertility in dairy goats, while also identifying key metabolic and endocrine mechanisms that influence reproductive performance in does subjected to repeated ES treatment. Forty-eight Saanen does were randomly assigned to two groups (24 goats each) that received ES treatments either thrice fortnightly (3-PMSG) or once (1-PMSG) simultaneously with the third ES treatment of the 3-PMSG group during the breeding season. ES treatment was performed via the intravaginal insertion of a controlled internal drug release (CIDR) device impregnated with 300 mg P4, followed by 300 IU PMSG injections 48 h before CIDR withdrawal. Blood was collected to detect the level of hormones and blood biochemical indices. Additionally, estrus rate, fecundity rate, body weight, size, and lactation performance were measured. The results showed that repeated ES treatment markedly decreased the estrus rate and fecundity rate of goats. Among the does in all groups, there was no substantial difference in follicle stimulating hormone, luteinising hormone, gonadotropin-releasing hormone, melatonin, growth hormone, PMSG, total cholesterol, total protein, and glucose levels, as well as the body weight, body size, and lactation performance. Repeated ES treatment elevated estrogen (E2) levels 36, 48, and 72 h post-CIDR removal; increased P4 upon CIDR insertion; and raised PMSG antibody levels 24, 48, and 72 h post-CIDR removal. The results suggest that elevated anti-PMSG levels are the primary reason for the decline in ES efficiency, and that high E2 and P4 levels at some time points also impair reproductive performance. These findings provide novel insights into the metabolic effects of repeated PMSG stimulation in goats, guiding future reproductive hormone use in breeding practices.https://www.frontiersin.org/articles/10.3389/fvets.2023.1333633/fullrepeated estrus synchronization treatmenthormone antibodypregnant mare serum gonadotropinprogesteronedairy goat |
| spellingShingle | Shuang Sun Ming Lv Huimin Niu Jun Luo Influence of repeated estrus synchronization treatment on hormone secretion, growth, and development of dairy goats Frontiers in Veterinary Science repeated estrus synchronization treatment hormone antibody pregnant mare serum gonadotropin progesterone dairy goat |
| title | Influence of repeated estrus synchronization treatment on hormone secretion, growth, and development of dairy goats |
| title_full | Influence of repeated estrus synchronization treatment on hormone secretion, growth, and development of dairy goats |
| title_fullStr | Influence of repeated estrus synchronization treatment on hormone secretion, growth, and development of dairy goats |
| title_full_unstemmed | Influence of repeated estrus synchronization treatment on hormone secretion, growth, and development of dairy goats |
| title_short | Influence of repeated estrus synchronization treatment on hormone secretion, growth, and development of dairy goats |
| title_sort | influence of repeated estrus synchronization treatment on hormone secretion growth and development of dairy goats |
| topic | repeated estrus synchronization treatment hormone antibody pregnant mare serum gonadotropin progesterone dairy goat |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2023.1333633/full |
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