A comprehensive overview of mitochondrial DNA 4977-bp deletion in cancer studies
Mitochondria are cellular machines essential for energy production. The biogenesis of mitochondria is a highly complex and it depends on the coordination of the nuclear and mitochondrial genome. Mitochondrial DNA (mtDNA) mutations and deletions are suspected to be associated with carcinogenesis. The...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-04-01
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| Series: | Oncology Reviews |
| Subjects: | |
| Online Access: | https://oncologyreviews.org/index.php/or/article/view/409 |
| _version_ | 1828074742916055040 |
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| author | Abdul Aziz Mohamed Yusoff Wan Salihah Wan Abdullah Siti Zulaikha Nashwa Mohd Khair Siti Muslihah Abd Radzak |
| author_facet | Abdul Aziz Mohamed Yusoff Wan Salihah Wan Abdullah Siti Zulaikha Nashwa Mohd Khair Siti Muslihah Abd Radzak |
| author_sort | Abdul Aziz Mohamed Yusoff |
| collection | DOAJ |
| description | Mitochondria are cellular machines essential for energy production. The biogenesis of mitochondria is a highly complex and it depends on the coordination of the nuclear and mitochondrial genome. Mitochondrial DNA (mtDNA) mutations and deletions are suspected to be associated with carcinogenesis. The most described mtDNA deletion in various human cancers is called the 4977-bp common deletion (mDNA4977) and it has been explored since two decades. In spite of that, its implication in carcinogenesis still unknown and its predictive and prognostic impact remains controversial. This review article provides an overview of some of the cellular and molecular mechanisms underlying mDNA4977 formation and a detailed summary about mDNA4977 reported in various types of cancers. The current knowledges of mDNA4977 as a prognostic and predictive marker are also discussed. |
| first_indexed | 2024-04-11T01:48:25Z |
| format | Article |
| id | doaj.art-19b9195e74aa44d19183903c944d2ac5 |
| institution | Directory Open Access Journal |
| issn | 1970-5557 1970-5565 |
| language | English |
| last_indexed | 2024-04-11T01:48:25Z |
| publishDate | 2019-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Oncology Reviews |
| spelling | doaj.art-19b9195e74aa44d19183903c944d2ac52023-01-03T07:01:13ZengFrontiers Media S.A.Oncology Reviews1970-55571970-55652019-04-0113110.4081/oncol.2019.409A comprehensive overview of mitochondrial DNA 4977-bp deletion in cancer studiesAbdul Aziz Mohamed Yusoff0Wan Salihah Wan Abdullah1Siti Zulaikha Nashwa Mohd Khair2Siti Muslihah Abd Radzak3Department of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, KelantanDepartment of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, KelantanDepartment of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, KelantanDepartment of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, KelantanMitochondria are cellular machines essential for energy production. The biogenesis of mitochondria is a highly complex and it depends on the coordination of the nuclear and mitochondrial genome. Mitochondrial DNA (mtDNA) mutations and deletions are suspected to be associated with carcinogenesis. The most described mtDNA deletion in various human cancers is called the 4977-bp common deletion (mDNA4977) and it has been explored since two decades. In spite of that, its implication in carcinogenesis still unknown and its predictive and prognostic impact remains controversial. This review article provides an overview of some of the cellular and molecular mechanisms underlying mDNA4977 formation and a detailed summary about mDNA4977 reported in various types of cancers. The current knowledges of mDNA4977 as a prognostic and predictive marker are also discussed.https://oncologyreviews.org/index.php/or/article/view/409Mitochondrial DNA (mtDNA) deletion4977-bp mtDNAcancer. |
| spellingShingle | Abdul Aziz Mohamed Yusoff Wan Salihah Wan Abdullah Siti Zulaikha Nashwa Mohd Khair Siti Muslihah Abd Radzak A comprehensive overview of mitochondrial DNA 4977-bp deletion in cancer studies Oncology Reviews Mitochondrial DNA (mtDNA) deletion 4977-bp mtDNA cancer. |
| title | A comprehensive overview of mitochondrial DNA 4977-bp deletion in cancer studies |
| title_full | A comprehensive overview of mitochondrial DNA 4977-bp deletion in cancer studies |
| title_fullStr | A comprehensive overview of mitochondrial DNA 4977-bp deletion in cancer studies |
| title_full_unstemmed | A comprehensive overview of mitochondrial DNA 4977-bp deletion in cancer studies |
| title_short | A comprehensive overview of mitochondrial DNA 4977-bp deletion in cancer studies |
| title_sort | comprehensive overview of mitochondrial dna 4977 bp deletion in cancer studies |
| topic | Mitochondrial DNA (mtDNA) deletion 4977-bp mtDNA cancer. |
| url | https://oncologyreviews.org/index.php/or/article/view/409 |
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