DNA methylation of insulin signaling pathways is associated with HOMA2-IR in primary myoblasts from older adults

DNA methylation of insulin signaling pathways is associated with HOMA2-IR in primary myoblasts from older adults

Abstract Background While ageing is associated with increased insulin resistance (IR), the molecular mechanisms underlying increased IR in the muscle, the primary organ for glucose clearance, have yet to be elucidated in older individuals. As epigenetic processes are suggested to contribute to the d...

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Bibliographic Details
Main Authors: Mark A. Burton, Emma S. Garratt, Matthew O. Hewitt, Hanan Y. Sharkh, Elie Antoun, Leo D. Westbury, Elaine M. Dennison, Nicholas C. Harvey, Cyrus Cooper, Julia L. MacIsaac, Michael S. Kobor, Harnish P. Patel, Keith M. Godfrey, Karen A. Lillycrop
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Skeletal Muscle
Subjects:
Insulin resistance
HOMA2-IR
Skeletal muscle
DNA methylation
Online Access:https://doi.org/10.1186/s13395-023-00326-y

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