Iron oxide nanoparticles carried by probiotics for iron absorption: a systematic review
Abstract Background One-third of the world's population has anemia, contributing to higher morbidity and death and impaired neurological development. Conventional anemia treatment raises concerns about iron bioavailability and gastrointestinal (GI) adverse effects. This research aims to establi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-04-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-023-01880-9 |
| _version_ | 1827966097379295232 |
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| author | Călina Ciont Amalia Mesaroș Oana Lelia Pop Dan Cristian Vodnar |
| author_facet | Călina Ciont Amalia Mesaroș Oana Lelia Pop Dan Cristian Vodnar |
| author_sort | Călina Ciont |
| collection | DOAJ |
| description | Abstract Background One-third of the world's population has anemia, contributing to higher morbidity and death and impaired neurological development. Conventional anemia treatment raises concerns about iron bioavailability and gastrointestinal (GI) adverse effects. This research aims to establish how iron oxide nanoparticles (IONPs) interact with probiotic cells and how they affect iron absorption, bioavailability, and microbiota variation. Methods Pointing to the study of the literature and developing a review and critical synthesis, a robust search methodology was utilized by the authors. The literature search was performed in the PubMed, Scopus, and Web of Science databases. Information was collected between January 2017 and June 2022 using the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis) protocols for systematic reviews and meta-analyses. We identified 122 compatible research articles. Results The research profile of the selected scientific articles revealed the efficacy of IONPs treatment carried by probiotics versus conventional treatment. Therefore, the authors employed content assessment on four topics to synthesize previous studies. The key subjects of the reviewed reports are the characteristics of the IONPs synthesis method, the evaluation of cell absorption and cytotoxicity of IONPs, and the transport of IONPs with probiotics in treating anemia. Conclusions To ensure a sufficient iron level in the enterocyte, probiotics with the capacity to attach to the gut wall transport IONPs into the enterocyte, where the maghemite nanoparticles are released. Graphical Abstract |
| first_indexed | 2024-04-09T17:44:40Z |
| format | Article |
| id | doaj.art-19bb33bcb6514d3cbdb343196fc756ca |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-09T17:44:40Z |
| publishDate | 2023-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-19bb33bcb6514d3cbdb343196fc756ca2023-04-16T11:24:10ZengBMCJournal of Nanobiotechnology1477-31552023-04-0121111910.1186/s12951-023-01880-9Iron oxide nanoparticles carried by probiotics for iron absorption: a systematic reviewCălina Ciont0Amalia Mesaroș1Oana Lelia Pop2Dan Cristian Vodnar3Department of Food Science, University of Agricultural Sciences and Veterinary MedicinePhysics and Chemistry Department, C4S Centre, Technical University of Cluj-NapocaDepartment of Food Science, University of Agricultural Sciences and Veterinary MedicineDepartment of Food Science, University of Agricultural Sciences and Veterinary MedicineAbstract Background One-third of the world's population has anemia, contributing to higher morbidity and death and impaired neurological development. Conventional anemia treatment raises concerns about iron bioavailability and gastrointestinal (GI) adverse effects. This research aims to establish how iron oxide nanoparticles (IONPs) interact with probiotic cells and how they affect iron absorption, bioavailability, and microbiota variation. Methods Pointing to the study of the literature and developing a review and critical synthesis, a robust search methodology was utilized by the authors. The literature search was performed in the PubMed, Scopus, and Web of Science databases. Information was collected between January 2017 and June 2022 using the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis) protocols for systematic reviews and meta-analyses. We identified 122 compatible research articles. Results The research profile of the selected scientific articles revealed the efficacy of IONPs treatment carried by probiotics versus conventional treatment. Therefore, the authors employed content assessment on four topics to synthesize previous studies. The key subjects of the reviewed reports are the characteristics of the IONPs synthesis method, the evaluation of cell absorption and cytotoxicity of IONPs, and the transport of IONPs with probiotics in treating anemia. Conclusions To ensure a sufficient iron level in the enterocyte, probiotics with the capacity to attach to the gut wall transport IONPs into the enterocyte, where the maghemite nanoparticles are released. Graphical Abstracthttps://doi.org/10.1186/s12951-023-01880-9Iron oxide nanoparticlesCytotoxicityProbioticsAbsorptionDrug deliveryAnemia |
| spellingShingle | Călina Ciont Amalia Mesaroș Oana Lelia Pop Dan Cristian Vodnar Iron oxide nanoparticles carried by probiotics for iron absorption: a systematic review Journal of Nanobiotechnology Iron oxide nanoparticles Cytotoxicity Probiotics Absorption Drug delivery Anemia |
| title | Iron oxide nanoparticles carried by probiotics for iron absorption: a systematic review |
| title_full | Iron oxide nanoparticles carried by probiotics for iron absorption: a systematic review |
| title_fullStr | Iron oxide nanoparticles carried by probiotics for iron absorption: a systematic review |
| title_full_unstemmed | Iron oxide nanoparticles carried by probiotics for iron absorption: a systematic review |
| title_short | Iron oxide nanoparticles carried by probiotics for iron absorption: a systematic review |
| title_sort | iron oxide nanoparticles carried by probiotics for iron absorption a systematic review |
| topic | Iron oxide nanoparticles Cytotoxicity Probiotics Absorption Drug delivery Anemia |
| url | https://doi.org/10.1186/s12951-023-01880-9 |
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