The applicability of the digit wrinkle scan to quantify sympathetic nerve function
Objective: Stimulated skin wrinkling test (SSW) has been launched as a non-invasive diagnostic procedure. However, no normative age dependent values have been reported that can be applied in clinical practice. The objectives of the study were to (1) collect age-dependent normative values according t...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Clinical Neurophysiology Practice |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2467981X22000166 |
| _version_ | 1798006436011180032 |
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| author | Maurice Sopacua Carla M.L. Gorissen-Brouwers Bianca T.A. de Greef Isis B.T. Joosten Catharina G. Faber Ingemar S.J. Merkies Janneke G.J. Hoeijmakers |
| author_facet | Maurice Sopacua Carla M.L. Gorissen-Brouwers Bianca T.A. de Greef Isis B.T. Joosten Catharina G. Faber Ingemar S.J. Merkies Janneke G.J. Hoeijmakers |
| author_sort | Maurice Sopacua |
| collection | DOAJ |
| description | Objective: Stimulated skin wrinkling test (SSW) has been launched as a non-invasive diagnostic procedure. However, no normative age dependent values have been reported that can be applied in clinical practice. The objectives of the study were to (1) collect age-dependent normative values according to the 5-point scale assessment for the SSW, to (2) determine reliability scores for the obtained norm values, and to (3) introduce a new digital method for SSW assessment, the Digit Wrinkle Scan© (DWS©) for detection of wrinkles in a more quantitative manner. Methods: Firstly, 82 healthy participants were included, divided in 5 age groups. The participants underwent SSW using lidocaine and prilocaine topical cream. Secondly, 35 healthy participants were included to test whether the DWS© could be a novel manner to assess the grade of wrinkling quantitatively. We determined the inter-observer reliability of both methods. Also, the intra-observer reliability was calculated for the DWS©. Results: We found a decrease in normative values over age. The inter-observer reliability of assessment by the 5-point scale method was moderate after SSW (Cohen’s k: 0.53). Results of the DWS© indicate that total wrinkle length per mm2 showed moderate to good agreement for the 4th and 5th digits after SSW, and a low agreement for the other digits. Conclusions: Age-dependent normative values were obtained according to the 5-point scale, but its clinical application is doubtful since we found a moderate inter-observer reliability. We introduced the DWS© as a possible new method in order to quantify the grade of wrinkling. Significance: We found unsatisfactory reliability scores, which hampers its usefulness for clinical practice. |
| first_indexed | 2024-04-11T12:54:41Z |
| format | Article |
| id | doaj.art-19bc50ebc46544029cbcae873b0fddef |
| institution | Directory Open Access Journal |
| issn | 2467-981X |
| language | English |
| last_indexed | 2024-04-11T12:54:41Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical Neurophysiology Practice |
| spelling | doaj.art-19bc50ebc46544029cbcae873b0fddef2022-12-22T04:23:05ZengElsevierClinical Neurophysiology Practice2467-981X2022-01-017115119The applicability of the digit wrinkle scan to quantify sympathetic nerve functionMaurice Sopacua0Carla M.L. Gorissen-Brouwers1Bianca T.A. de Greef2Isis B.T. Joosten3Catharina G. Faber4Ingemar S.J. Merkies5Janneke G.J. Hoeijmakers6Department of Neurology, School of Mental Health and Neuroscience, Maastricht University Medical Center+, Maastricht, The Netherlands; Department of Rehabilitation Medicine, Libra Revalidatie & Audiologie, Eindhoven, The Netherlands; Corresponding author at: Department of Neurology, School of Mental Health and Neuroscience, Maastricht University Medical Center+, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands.Department of Neurology, School of Mental Health and Neuroscience, Maastricht University Medical Center+, Maastricht, The NetherlandsDepartment of Neurology, School of Mental Health and Neuroscience, Maastricht University Medical Center+, Maastricht, The NetherlandsDepartment of Neurology, School of Mental Health and Neuroscience, Maastricht University Medical Center+, Maastricht, The NetherlandsDepartment of Neurology, School of Mental Health and Neuroscience, Maastricht University Medical Center+, Maastricht, The NetherlandsDepartment of Neurology, School of Mental Health and Neuroscience, Maastricht University Medical Center+, Maastricht, The Netherlands; Department of Neurology, Curaçao Medical Center, Willemstad, CuraçaoDepartment of Neurology, School of Mental Health and Neuroscience, Maastricht University Medical Center+, Maastricht, The NetherlandsObjective: Stimulated skin wrinkling test (SSW) has been launched as a non-invasive diagnostic procedure. However, no normative age dependent values have been reported that can be applied in clinical practice. The objectives of the study were to (1) collect age-dependent normative values according to the 5-point scale assessment for the SSW, to (2) determine reliability scores for the obtained norm values, and to (3) introduce a new digital method for SSW assessment, the Digit Wrinkle Scan© (DWS©) for detection of wrinkles in a more quantitative manner. Methods: Firstly, 82 healthy participants were included, divided in 5 age groups. The participants underwent SSW using lidocaine and prilocaine topical cream. Secondly, 35 healthy participants were included to test whether the DWS© could be a novel manner to assess the grade of wrinkling quantitatively. We determined the inter-observer reliability of both methods. Also, the intra-observer reliability was calculated for the DWS©. Results: We found a decrease in normative values over age. The inter-observer reliability of assessment by the 5-point scale method was moderate after SSW (Cohen’s k: 0.53). Results of the DWS© indicate that total wrinkle length per mm2 showed moderate to good agreement for the 4th and 5th digits after SSW, and a low agreement for the other digits. Conclusions: Age-dependent normative values were obtained according to the 5-point scale, but its clinical application is doubtful since we found a moderate inter-observer reliability. We introduced the DWS© as a possible new method in order to quantify the grade of wrinkling. Significance: We found unsatisfactory reliability scores, which hampers its usefulness for clinical practice.http://www.sciencedirect.com/science/article/pii/S2467981X220001665-point scaleDigit wrinkle scanSmall fiber neuropathyAutonomic functionDigit vasoconstrictionInter-observer reliability |
| spellingShingle | Maurice Sopacua Carla M.L. Gorissen-Brouwers Bianca T.A. de Greef Isis B.T. Joosten Catharina G. Faber Ingemar S.J. Merkies Janneke G.J. Hoeijmakers The applicability of the digit wrinkle scan to quantify sympathetic nerve function Clinical Neurophysiology Practice 5-point scale Digit wrinkle scan Small fiber neuropathy Autonomic function Digit vasoconstriction Inter-observer reliability |
| title | The applicability of the digit wrinkle scan to quantify sympathetic nerve function |
| title_full | The applicability of the digit wrinkle scan to quantify sympathetic nerve function |
| title_fullStr | The applicability of the digit wrinkle scan to quantify sympathetic nerve function |
| title_full_unstemmed | The applicability of the digit wrinkle scan to quantify sympathetic nerve function |
| title_short | The applicability of the digit wrinkle scan to quantify sympathetic nerve function |
| title_sort | applicability of the digit wrinkle scan to quantify sympathetic nerve function |
| topic | 5-point scale Digit wrinkle scan Small fiber neuropathy Autonomic function Digit vasoconstriction Inter-observer reliability |
| url | http://www.sciencedirect.com/science/article/pii/S2467981X22000166 |
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