Subglottic Masses Revealing Rosai-Dorfman Disease
Rosai-Dorfman disease (RDD) is an uncommon lymphoproliferative disorder; RDD with oropharyngeal involvement is extremely rare, especially in adults. A 65-year-old woman with a complaint of progressive dyspnoea since 2016 presented with laryngeal involvement of RDD. A laryngoscopy examination reveale...
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| Format: | Article |
| Language: | English |
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SMC MEDIA SRL
2023-02-01
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| Series: | European Journal of Case Reports in Internal Medicine |
| Subjects: | |
| Online Access: | https://www.ejcrim.com/index.php/EJCRIM/article/view/3389 |
| _version_ | 1811173067360043008 |
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| author | Mouna Snoussi Abir Derbel Yosr Hentati Hentati Zeineb Mnif Sameh Marzouk Zouheir Bahloul |
| author_facet | Mouna Snoussi Abir Derbel Yosr Hentati Hentati Zeineb Mnif Sameh Marzouk Zouheir Bahloul |
| author_sort | Mouna Snoussi |
| collection | DOAJ |
| description | Rosai-Dorfman disease (RDD) is an uncommon lymphoproliferative disorder; RDD with oropharyngeal involvement is extremely rare, especially in adults. A 65-year-old woman with a complaint of progressive dyspnoea since 2016 presented with laryngeal involvement of RDD. A laryngoscopy examination revealed two solid, polypoid masses in the subglottic region, and a laryngeal biopsy concluded chronic in ammation without signs of malignancy. A second biopsy of axillary lymph nodes was performed, supporting the diagnosis of histiocytosis. The patient was treated with corticosteroids and then lost to follow-up. In 2019, she suffered from dyspnoea and a hoarse voice. Laryngoscopy examination showed a polypoid lesion causing airway obstruction at 70% and thickening of the lateral wall of the cavum. Physical examination found left axillary and submandibular adenopathy, and computed tomography revealed thickening of the supraglottic larynx narrowing the laryngeal pathway. Lymphadenectomy with immunohistochemical analysis revealed typical protein positive S-100 histiocytes and emperipolesis. The patient was treated with high doses of corticosteroids for six weeks then these were progressively decreased. The outcome was favourable; the laryngeal lesion disappeared after two weeks of treatment. |
| first_indexed | 2024-04-10T17:41:47Z |
| format | Article |
| id | doaj.art-19bd45596b924830a2cb73ea371b5d6b |
| institution | Directory Open Access Journal |
| issn | 2284-2594 |
| language | English |
| last_indexed | 2024-04-10T17:41:47Z |
| publishDate | 2023-02-01 |
| publisher | SMC MEDIA SRL |
| record_format | Article |
| series | European Journal of Case Reports in Internal Medicine |
| spelling | doaj.art-19bd45596b924830a2cb73ea371b5d6b2023-02-03T11:08:08ZengSMC MEDIA SRLEuropean Journal of Case Reports in Internal Medicine2284-25942023-02-0110.12890/2023_0033892924Subglottic Masses Revealing Rosai-Dorfman DiseaseMouna Snoussi0Abir Derbel1Yosr Hentati Hentati2Zeineb Mnif3Sameh Marzouk4Zouheir Bahloul5Department of Internal Medicine, Hedi Chaker Hospital, Sfax, TunisiaDepartment of Internal Medicine, Hedi Chaker Hospital, Sfax, TunisiaDepartment of Medical Imaging, Hedi Chaker Hospital, Sfax, TunisiaDepartment of Medical Imaging, Hedi Chaker Hospital, Sfax, TunisiaDepartment of Internal Medicine, Hedi Chaker Hospital, Sfax, TunisiaDepartment of Internal Medicine, Hedi Chaker Hospital, Sfax, TunisiaRosai-Dorfman disease (RDD) is an uncommon lymphoproliferative disorder; RDD with oropharyngeal involvement is extremely rare, especially in adults. A 65-year-old woman with a complaint of progressive dyspnoea since 2016 presented with laryngeal involvement of RDD. A laryngoscopy examination revealed two solid, polypoid masses in the subglottic region, and a laryngeal biopsy concluded chronic in ammation without signs of malignancy. A second biopsy of axillary lymph nodes was performed, supporting the diagnosis of histiocytosis. The patient was treated with corticosteroids and then lost to follow-up. In 2019, she suffered from dyspnoea and a hoarse voice. Laryngoscopy examination showed a polypoid lesion causing airway obstruction at 70% and thickening of the lateral wall of the cavum. Physical examination found left axillary and submandibular adenopathy, and computed tomography revealed thickening of the supraglottic larynx narrowing the laryngeal pathway. Lymphadenectomy with immunohistochemical analysis revealed typical protein positive S-100 histiocytes and emperipolesis. The patient was treated with high doses of corticosteroids for six weeks then these were progressively decreased. The outcome was favourable; the laryngeal lesion disappeared after two weeks of treatment.https://www.ejcrim.com/index.php/EJCRIM/article/view/3389rosai dofmann diseaselaryngeal involvementsteroids |
| spellingShingle | Mouna Snoussi Abir Derbel Yosr Hentati Hentati Zeineb Mnif Sameh Marzouk Zouheir Bahloul Subglottic Masses Revealing Rosai-Dorfman Disease European Journal of Case Reports in Internal Medicine rosai dofmann disease laryngeal involvement steroids |
| title | Subglottic Masses Revealing Rosai-Dorfman Disease |
| title_full | Subglottic Masses Revealing Rosai-Dorfman Disease |
| title_fullStr | Subglottic Masses Revealing Rosai-Dorfman Disease |
| title_full_unstemmed | Subglottic Masses Revealing Rosai-Dorfman Disease |
| title_short | Subglottic Masses Revealing Rosai-Dorfman Disease |
| title_sort | subglottic masses revealing rosai dorfman disease |
| topic | rosai dofmann disease laryngeal involvement steroids |
| url | https://www.ejcrim.com/index.php/EJCRIM/article/view/3389 |
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