Genes with epigenetic alterations in human pancreatic islets impact mitochondrial function, insulin secretion, and type 2 diabetes

Genes with epigenetic alterations in human pancreatic islets impact mitochondrial function, insulin secretion, and type 2 diabetes

Abstract Epigenetic dysregulation may influence disease progression. Here we explore whether epigenetic alterations in human pancreatic islets impact insulin secretion and type 2 diabetes (T2D). In islets, 5,584 DNA methylation sites exhibit alterations in T2D cases versus controls and are associate...

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Detalles Bibliográficos
Autores principales: Tina Rönn, Jones K. Ofori, Alexander Perfilyev, Alexander Hamilton, Karolina Pircs, Fabian Eichelmann, Sonia Garcia-Calzon, Alexandros Karagiannopoulos, Hans Stenlund, Anna Wendt, Petr Volkov, Matthias B. Schulze, Hindrik Mulder, Lena Eliasson, Sabrina Ruhrmann, Karl Bacos, Charlotte Ling
Formato: Artículo
Lenguaje:English
Publicado: Nature Portfolio 2023-12-01
Colección:Nature Communications
Acceso en línea:https://doi.org/10.1038/s41467-023-43719-9

Internet

https://doi.org/10.1038/s41467-023-43719-9

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